A5022279903- Glioma Diagnosis and Treatment
- Advanced Neuroimaging Techniques and Applications
- Meningioma and schwannoma management
- Advanced MRI Techniques and Applications
- Neuroblastoma Research and Treatments
- Fetal and Pediatric Neurological Disorders
- MRI in cancer diagnosis
- Cerebrospinal fluid and hydrocephalus
- Vestibular and auditory disorders
- Radiomics and Machine Learning in Medical Imaging
- Hedgehog Signaling Pathway Studies
- Neonatal and fetal brain pathology
- Neurofibromatosis and Schwannoma Cases
- Pituitary Gland Disorders and Treatments
- Craniofacial Disorders and Treatments
- Chromatin Remodeling and Cancer
- Epilepsy research and treatment
- Hearing, Cochlea, Tinnitus, Genetics
- Infectious Encephalopathies and Encephalitis
- Atomic and Subatomic Physics Research
- Vascular Malformations Diagnosis and Treatment
- Adrenal and Paraganglionic Tumors
- Ophthalmology and Eye Disorders
- Infectious Diseases and Tuberculosis
- Bacterial Infections and Vaccines
Alder Hey Children's NHS Foundation Trust
2016-2025
Alder Hey Children's Hospital
2014-2024
University of Liverpool
2014-2024
Baylor College of Medicine
2012-2023
National Health Service
2018
Children’s Foundation
2016
Walton Centre
2013-2015
National Institute for Health Research
2015
Meningitis Research Foundation
2015
Oxford Biomedical Research
2015
Abstract Background Pediatric low-grade glioma (pLGG) is essentially a single pathway disease, with most tumors driven by genomic alterations affecting the mitogen-activated protein kinase/ERK (MAPK) pathway, predominantly KIAA1549::BRAF fusions and BRAF V600E mutations. This makes pLGG an ideal candidate for MAPK pathway-targeted treatments. The type I inhibitor, dabrafenib, in combination MEK trametinib, has been approved United States Food Drug Administration systemic treatment of...
Background. The emergence of influenza A(H1N1) 2009 was met with increased reports associated neurological manifestations. We aimed to describe manifestations in adults and children the United Kingdom that presented at this time.
Migrating partial seizures of infancy, also known as epilepsy infancy with migrating focal seizures, is a rare early infantile epileptic encephalopathy poor prognosis, presenting in the first year life. A national surveillance study was undertaken conjunction British Paediatric Neurology Surveillance Unit to further define clinical, pathological and molecular genetic features this disorder. Fourteen children were reported during 2 period (estimated prevalence 0.11 per 100,000 children). The...
Low grade gliomas (LGGs) constitute the largest, yet clinically and (molecular-) histologically heterogeneous group of pediatric brain tumors WHO grades I II occurring throughout all age groups at central nervous system (CNS) sites. The are characterized by a slow growth rate may show periods arrest. Around 40% LGG patients can be cured complete neurosurgical resection followed close observation. In case relapse, second often is possible. Following incomplete observation recommended, as long...
Posterior fossa syndrome (PFS) is an important complication of posterior surgery in children. The pathophysiology this condition remains unclear, but there evidence implicating surgical injury the proximal efferent cerebellar pathway (pECP) and vermis to PFS. We aimed evaluate if diffusion abnormalities involving these structures on final intraoperative MRI can predict development Diffusion-weighted imaging from 31 resections were anonymized evaluated for dentate nucleus, superior peduncle,...
Background: Despite previous identification of pre-operative clinical and radiological predictors post-operative paediatric cerebellar mutism syndrome (CMS), a unifying risk stratification model for use during surgical consent is currently lacking. The aim the project to develop simple imaging-based scoring scheme stratify patients in terms CMS risk.Methods: Pre-operative features were recorded retrospectively assembled cohort 89 posterior fossa tumour from two major UK treatment centers...
The imaging and subsequent accurate diagnosis of paediatric brain tumours presents a radiological challenge, with magnetic resonance playing key role in providing tumour specific information. Diffusion weighted perfusion are commonly used to aid the non-invasive children's tumours, but usually evaluated by expert qualitative review. Quantitative studies mainly single centre modality. aim this work was combine multi-centre diffusion imaging, machine learning, develop learning based...
Abstract To determine if apparent diffusion coefficients (ADC) can discriminate between posterior fossa brain tumours on a multicentre basis. A total of 124 paediatric patients with (including 55 Medulloblastomas, 36 Pilocytic Astrocytomas and 26 Ependymomas) were scanned using weighted imaging across 12 different hospitals 18 scanners. Apparent coefficient maps produced histogram data was extracted from tumour regions interest. Total histograms metrics (mean, variance, skew, kurtosis 10th,...
Abstract Pediatric low-grade glioma (pLGG) is the most common childhood brain tumor group. The natural history, when curative resection not possible, one of a chronic disease with periods stability and episodes progression. While there high overall survival rate, many patients experience significant potentially lifelong morbidities. majority pLGGs have an underlying activation RAS/MAPK pathway due to mutational events, leading use molecularly targeted therapies in clinical trials, recent...
Background: The dentato-thalamo-cortical (DTC) pathway is recognized as the anatomical substrate for postoperative pediatric cerebellar mutism (POPCMS), a well-recognized complication affecting up to 31% of children undergoing posterior fossa brain tumour resection. proximal structures DTC also form segment Guillain and Mollaret triangle, neural network which when disrupted causes hypertrophic olivary degeneration (HOD) inferior nucleus (ION). We hypothesize that there an association between...
Abstract Pediatric central nervous system (CNS) tumors represent the most common cause of cancer-related death in children aged 0–14 years. They differ from their adult counterparts, showing extensive clinical and molecular heterogeneity as well a challenging histopathological spectrum that often impairs accurate diagnosis. Here, we use DNA methylation-based CNS tumor classification combination with copy number, RNA-seq, ChIP-seq analysis to characterize newly identified type. In addition,...
Purpose 3T magnetic resonance scanners have boosted clinical application of 1 H‐MR spectroscopy (MRS) by offering an improved signal‐to‐noise ratio and increased spectral resolution, thereby identifying more metabolites extending the range metabolic information. Spectroscopic data from 1.5T MR has been shown to discriminate between pediatric brain tumors applying machine learning techniques further aid diagnosis. The purpose this multi‐center study was investigate discriminative potential...
Abstract Brain tumors represent the highest cause of mortality in pediatric oncological population. Diagnosis is commonly performed with magnetic resonance imaging. Survival biomarkers are challenging to identify due relatively low numbers individual tumor types. 69 children biopsy-confirmed brain were recruited into this study. All participants had perfusion and diffusion weighted imaging at diagnosis. Imaging data processed using conventional methods, a Bayesian survival analysis...
Cerebellar Mutism Syndrome (CMS) is a neurological complication of posterior fossa (PF) tumour surgery in children, and postoperative speech impairment (POSI) the cardinal symptom CMS. The role volume on risk POSI remains unexplored. This study investigates association between POSI. We included 360 patients from European CMS with available preoperative T1-weighted contrast-enhanced brain MRI. Speech status was assessed within two weeks postoperatively categorised into three levels: habitual...
ABSTRACT Aims Embryonal tumours with PLAGL1 or PLAGL2 amplification (ET, PLAGL) show substantial heterogeneity regarding their clinical characteristics and have been treated inconsistently, resulting in diverse outcomes. In this study, we aimed to evaluate the behaviour of ET, PLAGL elucidate response pattern across different applied treatment regimens. Methods We conducted an in‐depth retrospective analysis serial imaging data 18 patients (nine each amplified). Results Patients ‐amplified...