A5007555980- Glioma Diagnosis and Treatment
- Cerebrospinal fluid and hydrocephalus
- Spinal Dysraphism and Malformations
- Fetal and Pediatric Neurological Disorders
- Brain Metastases and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Testicular diseases and treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Child Abuse and Related Trauma
- Meningioma and schwannoma management
- Brain Tumor Detection and Classification
- Neuroblastoma Research and Treatments
- Neonatal and fetal brain pathology
- MicroRNA in disease regulation
- Neurosurgical Procedures and Complications
- Augmented Reality Applications
- Vascular Malformations Diagnosis and Treatment
- Nerve injury and regeneration
- Chromatin Remodeling and Cancer
- Cancer Research and Treatments
- Advanced Neural Network Applications
- Neuroscience and Neuropharmacology Research
- Cancer-related molecular mechanisms research
- Lung Cancer Research Studies
- Restraint-Related Deaths
Kansai Medical University
2015-2024
Osaka National Hospital
2012-2024
Japanese Society of Medical Oncology
2024
Stony Brook University
2022
Neurological Surgery
2022
KU Leuven
2022
Saitama International Medical Center
2020
Saitama Medical University
2020
Wakayama Medical University
2019-2020
Osaka University
1995-2019
The prognostic impact of TERT mutations has been controversial in IDH-wild tumors, particularly glioblastomas (GBM). controversy may be attributable to presence potential confounding factors such as MGMT methylation status or patients' treatment. This study aimed evaluate the on patient outcome association with various a large series adult diffuse gliomas. We analyzed total 951 gliomas from two cohorts (Cohort 1, n = 758; Cohort 2, 193) for IDH1/2, 1p/19q, and promoter status. combined...
Brain trauma in humans increases the risk for developing Alzheimer disease (AD) and may induce acute formation of AD-like plaques containing amyloid β (Aβ). To further explore potential link between brain neurodegeneration, we conducted neuropathological studies using a pig model diffuse injury. injury was induced anesthetized animals via nonimpact head rotational acceleration 110° over 20 ms coronal plane (n = 15 injured, n 3 noninjured). At 1,3, 7, 10 days post-trauma, control injured were...
Immediate and prolonged coma following brain trauma has been shown to result from diffuse axonal injury (DAI). However, the relationship between distribution of damage posttraumatic not examined. In present study, authors examine that relationship.To explore potential anatomical origins coma, used a model inertial in pig. Anesthetized miniature swine were subjected nonimpact-induced head rotational acceleration along either coronal or axial plane (six pigs each group). was consistently...
Abstract Molecular biological characterization of tumors has become a pivotal procedure for glioma patient care. The aim this study is to build conventional MRI-based radiomics model predict genetic alterations within grade II/III gliomas attempting implement lesion location information in the improve diagnostic accuracy. One-hundred and ninety-nine patients were enrolled. Three molecular subtypes identified: IDH1/2 -mutant, -mutant with TERT promoter mutation, IDH- wild type. A total 109...
Extensive molecular analyses of ependymal tumors have revealed that supratentorial and posterior fossa ependymomas distinct profiles are likely to be different diseases. The presence C11orf95-RELA fusion genes in a subset (ST-EPN) indicated the existence subgroups. However, pathogenesis RELA fusion-negative remains elusive. To investigate these validate classification tumors, we conducted thorough 113 locally diagnosed from 107 patients Japan Pediatric Molecular Neuro-Oncology Group. All...
Activation of transcription factor, nuclear factor kappa B (NF-kappaB), has been shown to play a key role in inflammatory response, neuronal survival and signaling. We investigated the regional temporal distribution activated NF-kappaB rats at 1 h, 2 24 48 week, weeks, month, months, 6 year following brain injury rats. Early after trauma (1-2 h), was detected axons, subsequently found cytoplasm nucleus neurons by h lasting up week. In addition, posttrauma, microglia/macrophages astrocytes...
Traumatic brain injury (TBI) finite element (FE) analyses have evolved from crude geometric representations of the skull and system into sophisticated models which take account distinct anatomical features. Two FE modeling approaches to for relative motion that occurs between cerebral cortex during TBI. The first approach assumes can be estimated by representing cerebrospinal fluid inside subarachnoid space as a low shear modulus, virtually incompressible solid. second approximated defining...
Abstract We attempted to establish a magnetic resonance imaging (MRI)-based radiomic model for stratifying prognostic subgroups of newly diagnosed glioblastoma (GBM) patients and predicting O (6)-methylguanine-DNA methyltransferase promotor methylation ( pMGMT -met) status the tumor. Preoperative MRI scans from 201 GBM were included in this study. A total 489 texture features including first-order feature, second-order 162 datasets, location data 182 datasets collected. Supervised principal...
Abstract Identification of genotypes is crucial for treatment glioma. Here, we developed a method to predict tumor using pretrained convolutional neural network (CNN) from magnetic resonance (MR) images and compared the accuracy that diagnosis based on conventional radiomic features patient age. Multisite preoperative MR 164 patients with grade II/III glioma were grouped by IDH TERT promoter (pTERT) mutations as follows: (1) wild type, (2) pTERT co-mutations, (3) mutant type. We applied CNN...
Targeting immune checkpoint proteins has recently gained substantial attention due to the dramatic success of this strategy in clinical trials for some cancers. Inducible T-cell co-stimulator ligand (ICOSLG) is a member B7 family regulatory ligands, expression which cancer implicated disease progression regulation antitumor adaptive immunity. Although aberrant ICOSLG been reported glioma cells, underlying mechanisms that promote glioblastoma (GBM) remain elusive.Here, we investigated causal...
Although accumulation of neurofilament (NF) proteins in axons has been recognized as a prominent feature brain trauma, the temporal course specific NF subtypes not well established. In present study, 17 miniature swine were subjected to nonimpact inertial injury. At 3 hours (h), 6 h, 24 days, 7 and 10 days post-trauma, immunohistochemical analysis was performed determine axonal NF-light (NF-L), rod sidearm domains phosphorylation states NF-medium (NF-M), heavy (NF-H). We found that NF-L...
Abstract Background and Aims. The purpose of the present study was to examine efficacy transplantation mouse embryonic-stem-(ES)-cell-derived tyrosine hydroxylase-positive (TH+) cells into Parkinsonian mice using behavioral tests immunohistochemical evaluation. Methods. Undifferentiated ES carrying enhanced green fluorescent protein (EGFP) gene were differentiated a cell population containing TH+ neurons five-step in vitro differentiation method. These ES-cell-derived used as allografts...
ABSTRACT Several suspensions and emulsions containing commercial sodium caseinate or skim milk were gelatinized by Ca 2+ ‐independent microbial transglutaminase treatment. The characteristics of the gels largely affected enzyme concentrations employed. For generally higher concentration gave steep decreases in breaking strength, strain cohesiveness gels. creep tests on emulsified prepared to two different showed that gel made with a was more viscoelastic. gels, treatment caused substantial...
In several models of traumatic brain injury in rodents, remarkably progressive tissue loss and neuron death has been observed accompanied by expanding ventricles. Here, we explored potential cell proliferation the subventricular zone (SVZ) response to this posttraumatic neurodegeneration. Four-month-old rats (n = 57) were subjected parasagittal fluid-percussion or sham treatment (no injury), their brains harvested at 2 weeks, months, 6 1 year 6-8/group) after treatment. Brain sections (6 μm)...
The diagnosis and prognostication of glioblastoma (GBM) remain to be solely dependent on histopathological findings few molecular markers, despite the clinical heterogeneity in this entity. To address issue, we investigated prognostic impact copy number alterations (CNAs) using two population-based IDH-wild-type GBM cohorts: an original Japanese cohort a dataset from Cancer Genome Atlas (TCGA). disproportions between these cohorts were dissected light differences GBM. was collected cases...
Machine learning models for automated magnetic resonance image segmentation may be useful in aiding glioma detection. However, the differences among facilities cause performance degradation and impede This study proposes a method to solve this issue. We used data from Multimodal Brain Tumor Image Segmentation Benchmark (BraTS) Japanese cohort (JC) datasets. Three tumor are developed. In our methodology, BraTS JC trained on datasets, respectively, whereas fine-tuning developed model...
<h3>BACKGROUND AND PURPOSE:</h3> Noninvasive radiologic evaluation of glioma can facilitate correct diagnosis and detection malignant transformation. Although positron-emission tomography is considered valuable in the care patients with gliomas, <sup>18</sup>F-fluorodeoxyglucose <sup>11</sup>C-methionine have reportedly shown ambiguous results terms grading prognostication. The present study compared diagnostic prognostic capabilities diffusion tensor imaging, FDG, PET nonenhancing gliomas....
Abstract TERT promoter mutations are commonly associated with 1p/19q codeletion in IDH-mutated gliomas. However, whether these have an impact on patient survival independent of is unknown. In this study, we investigated the glioma cases. Detailed clinical information and molecular status data were collected for a cohort 560 adult patients Among patients, 279 had both mutation codeletion, while 30 either (n = 24) or 6) alone. A univariable Cox proportional hazard analysis using genetic...
Central nervous system (CNS) germ cell tumors (GCTs) are neoplasms predominantly arising in pediatric and young adult populations. While germinomas generally respond to chemotherapy radiation, non-germinomatous GCTs (NGGCTs) require more intensive treatment. This study aimed determine whether 12p gain could predict the prognosis of CNS GCTs.Eighty-two were included this study. The was defined by an additional background potential polyploidy or polysomy. Cases analyzed using Illumina...
CNS germ cell tumors (GCTs) predominantly develop in pediatric and young adult patients with variable responses to surgery, radiation, chemotherapy. This study aimed examine the complex largely unknown pathogenesis of GCTs.We used a combined transcriptomic methylomic approach 84 cases conducted an integrative analysis normal cells undergoing embryogenesis testicular GCTs.Genome-wide transcriptome GCTs indicated that germinoma had profile representative primitive during early high...