A5090934236- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Cancer Genomics and Diagnostics
- MicroRNA in disease regulation
- Meningioma and schwannoma management
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Neuroblastoma Research and Treatments
- CNS Lymphoma Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Lung Cancer Research Studies
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Radiomics and Machine Learning in Medical Imaging
- Chromatin Remodeling and Cancer
- Bone Tumor Diagnosis and Treatments
- Lymphoma Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Cerebrospinal fluid and hydrocephalus
- Brain Tumor Detection and Classification
- Lung Cancer Treatments and Mutations
- Moyamoya disease diagnosis and treatment
- Circular RNAs in diseases
- Oral and Maxillofacial Pathology
Tokyo Metropolitan Komagome Hospital
2011-2025
Dokkyo Medical University
2016-2021
Gifu University
2018
The University of Tokyo
2015-2017
Keio University
2017
The prognostic impact of TERT mutations has been controversial in IDH-wild tumors, particularly glioblastomas (GBM). controversy may be attributable to presence potential confounding factors such as MGMT methylation status or patients' treatment. This study aimed evaluate the on patient outcome association with various a large series adult diffuse gliomas. We analyzed total 951 gliomas from two cohorts (Cohort 1, n = 758; Cohort 2, 193) for IDH1/2, 1p/19q, and promoter status. combined...
Abstract Ependymomas encompass multiple clinically relevant tumor types based on localization and molecular profiles. Tumors of the methylation class “spinal ependymoma” (SP-EPN) represent most common intramedullary neoplasms in children adults. However, their developmental origin is ill-defined, data are scarce, potential heterogeneity within SP-EPN remains unexplored. The only known recurrent genetic events loss chromosome 22q NF2 mutations, but neither frequency these alterations nor...
Among diffuse gliomas, oligodendrogliomas show relatively better prognosis, respond well to radiotherapy and chemotherapy, seldom progress very aggressive tumors. To elucidate the genetic epigenetic background for such behavior tumor evolution during relapse, we comparatively analyzed 12 pairs of primary recurrent with 1p/19q-codeletion. Initial treatment these patients was mostly chemotherapy alone. Temozolomide used 3, procarbazine, nimustine vincristine (PAV chemotherapy) were 7 patients....
Machine learning models for automated magnetic resonance image segmentation may be useful in aiding glioma detection. However, the differences among facilities cause performance degradation and impede This study proposes a method to solve this issue. We used data from Multimodal Brain Tumor Image Segmentation Benchmark (BraTS) Japanese cohort (JC) datasets. Three tumor are developed. In our methodology, BraTS JC trained on datasets, respectively, whereas fine-tuning developed model...
OBJECTIVE Chordoma is a slow-growing but clinically malignant tumor, and the prognosis remains poor in many cases. There strong impetus to develop more effective targeted molecular therapies. On this basis, authors investigated potential of Brachyury, transcription factor involved notochord development, as candidate target for treatment chordoma. METHODS Brachyury gene copy number expression levels were evaluated by quantitative polymerase chain reaction 27 chordoma samples, transcriptomes...
Recent studies have demonstrated that tumor-driving alterations are often different among gliomas originated from brain regions and underscored the importance of analyzing molecular characteristics stratified by region. Therefore, to elucidate diffuse cerebellar (DCGs), 27 adult, mostly glioblastoma cases were analyzed. Comprehensive analysis using whole-exome sequencing, RNA Infinium methylation array (n = 17) their distinct profile compared in other regions. Frequent mutations...
Abstract To elucidate the mechanisms of malignant progression lower-grade glioma, molecular profiling using methylation array, whole-exome sequencing, and RNA sequencing was performed for 122, 36 31 gliomas, respectively. This cohort included 24 matched pairs initial gliomas recurrent tumors, most which showed progression. Nearly half IDH-mutant glioblastomas that had progressed from exhibited characteristic partial DNA demethylation in previously methylated genomic regions their...
Abstract TERT promoter mutations are commonly associated with 1p/19q codeletion in IDH-mutated gliomas. However, whether these have an impact on patient survival independent of is unknown. In this study, we investigated the glioma cases. Detailed clinical information and molecular status data were collected for a cohort 560 adult patients Among patients, 279 had both mutation codeletion, while 30 either (n = 24) or 6) alone. A univariable Cox proportional hazard analysis using genetic...
Patients with advanced cancer undergo comprehensive genomic profiling in Japan only after treatment options have been exhausted. a very poor prognosis were not able to tests, resulting selection bias called length bias, which makes accurate survival analysis impossible. The actual impact of on the overall patients who undergone tests is unclear, yet appropriate methods for adjusting developed. To assess survival, we established simulation-based model adjustment. This study utilized...
Abstract Background This study aimed to investigate what treatment are selected for malignant brain tumors, particularly glioblastoma (GBM) and primary central nervous system lymphoma (PCNSL), in real-world Japan the costs involved. Methods We conducted a questionnaire survey regarding selections newly diagnosed GBM PCNSL treated between July 2021 June 2022 among 47 institutions Clinical Oncology Group-Brain Tumor Study Group. calculated total cost per month of initial therapy or PCNSL....
Glycosphingolipids are major components of the membrane raft, and several kinds viruses bacterial toxins known to bind glycosphingolipids in raft. Since viral genes pathogenic proteins that taken into cells directly delivered their target organelles, caveolae/raft-mediated endocytosis represents a promising pathway for specific delivery. In present study, we demonstrated ability an artificial pentadecapeptide, which binds ganglioside GM3, deliver protein by endocytosis. The cellular uptake...
IDH ‐mutant gliomas are classified into astrocytic or oligodendroglial tumors by 1p/19q status in the WHO 2016 classification, with latter presenting characteristic morphology and better prognosis general. However, morphological genetic features within each category varied, there might be distinguishable subtypes. We analyzed 170 grade II‐IV resected our institution. was microsatellite analysis, mutations were next‐generation sequencing Sanger sequencing. For validation, Brain Lower Grade...
Some patients with temporal lobe brain tumours show aggressive or escape behaviour during awake surgery. As the amygdala plays a critical role in coping stress, we evaluated whether left right was involved six undergoing surgery for tumours.Brain were located cases 1-3 and 4-6. In 1, 2, 4 5, invaded amygdala.In case patient showed before partial removal of surgery; just after amygdala, calm cooperative. when tumour near removed. 3, awakening 4, initiated. 5 6, upon initiation from lobe.In...
Intravascular lymphoma (IVL) has been characterized in many case reports by multiple white matter lesions reflecting ischemic changes. In contrast, there are very few of cerebral or cerebellar hemorrhage resulting from IVL. A 56-year-old woman was referred to our department with two-week history headache, nausea, and poor appetite. Gadolinium (Gd)-enhanced magnetic resonance imaging (MRI) showed dilated veins on the surface. No were detected diffusion-weighted images. Three days after...
Brain invasion by chronic lymphocytic leukemia (CLL) is very rare, and only a handful of cases have been reported. We here report case 61‐year‐old woman who had treated for CLL 14 years presenting with progressive mental disturbance. Magnetic resonance imaging (MRI) showed discontinuous ring‐enhancing lesions compatible the “open ring” sign, which was considered demyelinating disorder, in both frontal lobes. However, on histological examination biopsied specimen, infiltration small...
A 46-year-old female patient with glioblastoma multiforme (GBM), IDH wild type developed severe pancytopenia 5 months after postoperative chemoradiotherapy. Bone marrow aspirate showed normocellular 70.0% abnormal cells, which suggested the possibility of acute myeloid leukemia. Immunophenotypic analysis did not show any hematological lineage markers, except for cluster differentiation 56. The results immunohistochemical staining glial fibrillary acidic protein and oligodendrocyte...
<title>Abstract</title> Background The cognitive dysfunction associated with cerebellar tumors in adults is not well understood. We herein evaluated the effect of and surgery on function adult patients before after resection. Methods Eighteen who underwent resection a tumor at study center between 2016 2022 were retrospectively analyzed. Their clinical characteristics, surgical complications, neuropsychological test scores thoroughly reviewed. Results Of 18 patients, nine male, median age...