A5043354204- Vascular Malformations Diagnosis and Treatment
- Intracranial Aneurysms: Treatment and Complications
- Neurosurgical Procedures and Complications
- Spinal Fractures and Fixation Techniques
- Spinal Hematomas and Complications
- Glioma Diagnosis and Treatment
- Cerebrospinal fluid and hydrocephalus
- Cervical and Thoracic Myelopathy
- Spine and Intervertebral Disc Pathology
- Head and Neck Surgical Oncology
- Spinal Dysraphism and Malformations
- Intracerebral and Subarachnoid Hemorrhage Research
- Meningioma and schwannoma management
- Aortic Disease and Treatment Approaches
- Trigeminal Neuralgia and Treatments
- Neurogenesis and neuroplasticity mechanisms
- Neurofibromatosis and Schwannoma Cases
- Nerve Injury and Rehabilitation
- Neuroblastoma Research and Treatments
- Sarcoma Diagnosis and Treatment
- Axon Guidance and Neuronal Signaling
- Spinal Cord Injury Research
- Renal and related cancers
- Musculoskeletal pain and rehabilitation
- MicroRNA in disease regulation
Tokyo Metropolitan Neurological Hospital
2016-2025
Manipal University College Malaysia
2019
University of Tsukuba
2017
St. Luke's International Hospital
2017
Oita University Hospital
2017
Osaka City General Hospital
2017
Hyogo Medical University
2017
University of Tokyo Hospital
2000-2016
The University of Tokyo
2001-2012
Toranomon Hospital
2012
OBJECTIVE The aim of this retrospective multicenter cohort study was to assess the details angioarchitecture arteriovenous fistulas (AVFs) at craniocervical junction (CCJ) and determine associations between angiographic characteristics clinical presentations outcomes. METHODS authors analyzed data for patients with CCJ AVFs from 20 participating centers that are members Japanese Society Neuroendovascular Therapy (JSNET). Angiographic findings (feeding artery, location AV shunt, draining...
The purpose of this study is to compare the angiographic and clinical characteristics spinal epidural arteriovenous fistulas (SEAVFs) dural (SDAVFs) thoracolumbar spine.A total 168 cases diagnosed as or extradural spine were collected from 31 centers. Angiography findings, including symptoms, sex, history surgery/trauma, retrospectively reviewed. Angiographic images evaluated, with a special interest in levels, feeders, shunt points, shunted pouch its location, drainage pattern, by 6 readers...
Abstract Ependymomas encompass multiple clinically relevant tumor types based on localization and molecular profiles. Tumors of the methylation class “spinal ependymoma” (SP-EPN) represent most common intramedullary neoplasms in children adults. However, their developmental origin is ill-defined, data are scarce, potential heterogeneity within SP-EPN remains unexplored. The only known recurrent genetic events loss chromosome 22q NF2 mutations, but neither frequency these alterations nor...
✓ The authors advocate the use of a transparent sheath for guiding an endoscope, simple and unique tool endoscopic surgery, describe preliminary results its application in evacuation hypertensive intracerebral hematomas. This is 10-cm-long tube made clear acrylic plastic, which greatly improves visualization surgical field through 2.7-mm nonangled endoscope inserted within. Between April 1997 December 1998, performed hematomas by using this into patients' heads burr hole. In nine consecutive...
The purpose of this study was to describe significant CT myelography findings for determination the leak site and outcome targeted epidural blood patch (EBP) in patients with spontaneous CSF leaks.During 2005-2013, leaks were diagnosed 12 orthostatic headaches. received EBP on basis assessments.Computed tomography myelograms revealed ventral extradural collection contrast medium distributed over multiple spinal levels (average 16 levels). Intraforaminal extravasations observed at 8.2 For 8...
Hirayama disease, juvenile muscular atrophy of the distal upper extremity, is a rare type cervical flexion segmental myelopathy and its etiology still being debated. Two theories have been proposed: "contact pressure" theory "tight dural canal in flexion" theory. Previously reported treatments, including conservative neck collar therapy surgical spinal fusion, used fixation spine with aim avoiding contact pressure between cord anterior structures. On other hand, treatment by duraplasty...
To establish a clinician-led guideline for the diagnosis and treatment of Hirayama disease (HD) using modified Delphi technique.Based on combination systematic review opinion ten experts, protocol consensus diagnosis, follow-up assessment HD was established. A 3-round survey then performed by more than 40 panelists from various countries world. Both levels evidence agreement were derived in all statements finial guideline.A total 47 experts 6 enrolled expert panel this study. Highly...
Craniocervical junction (CCJ) arteriovenous fistulas (AVFs) are treated using neurosurgical or endovascular options; however, there is still no consensus on the safest and most effective treatment. The present study compared treatment results of procedures for CCJ AVFs, specifically regarding retreatment, complications, outcomes.
The clinical differences were evaluated in spinal hemangioblastoma between patients with sporadic disease and von Hippel-Lindau (VHL) syndrome. distribution of hemangioblastomas the central nervous system was investigated 56 treated 1988 2008 at University Tokyo Hospital. characteristics compared 35 including 17 18 VHL syndrome our hospital three affiliated institutions. Spinal much more prevalent (88.2%) than (20.5%, p < 0.001). associated diagnosed a decade earlier (p = 0.007) less severe...
OBJECT The microvascular anatomy of spinal dural arteriovenous fistulas (AVFs), especially the relationships vessels with dura mater, has yet to be angiographically demonstrated in detail and proven histologically. METHODS From January 2012 through April 2014, a total 7 patients AVFs thoracic region underwent open microsurgical obliteration at Tokyo Metropolitan Neurological Hospital. was comprehensively assessed by using advanced microangiography, including 3D computer graphics...
OBJECTIVE A recent comparative analysis between neurosurgical and endovascular treatments for craniocervical junction (CCJ) arteriovenous fistulas (AVFs) revealed better treatment outcomes in the neurosurgery group than group. This finding was attributed to higher expected rate of ischemic complications (26% vs 7.7%, p = 0.037). The aim present study describe associated with CCJ AVFs. METHODS descriptive authorized by Neurospinal Society Japan. Data from 97 consecutive patients AVFs who...
Digital subtraction (DS) angiography is the gold standard for diagnosing spinal vascular malformations. Recently, multidetectorrow spiral CT and contrast-enhanced MR have been introduced as screening examinations before DS angiography. These methods, however, do not always determine accurate location of an arteriovenous shunt because resulting images lack information about cord or dura mater.Between April 2009 December 2010, 13 patients underwent imaging evaluations malformations at authors'...
Spinal arteriovenous shunts are rare vascular lesions and classified into 4 types (types I-IV). Due to rapid advances in neuroimaging, spinal epidural AVFs (edAVFs), which similar type I dural (dAVFs), have recently been increasingly reported. These 2 entities several important differences that influence the treatment strategy selected. The purposes of present study were compare angiographic clinical between edAVFs dAVFs provide strategies for based on a multicenter cohort.
BACKGROUND AND OBJECTIVES: Craniocervical junction (CCJ) arteriovenous fistulas (AVFs) presenting with subarachnoid hemorrhage (SAH) are rare conditions, the optimal timing and approach to treatment still debated among neurosurgeons. The aim of this study was characterize CCJ AVF–related SAH determine appropriate surgical in a multicenter study. METHODS: Data from 111 consecutive patients AVF, including 51 SAH, were collected 29 centers across Japan. vascular anatomy, diagnosis, treatment,...
The purpose of the present study was to compare treatment success rates primary neurosurgical and endovascular treatments in patients with spinal dural arteriovenous fistulas (dAVFs).
Although p53 controls cell death after various stresses, its role in neuronal brain ischemia is poorly understood. To address this issue, we subjected p53-deficient (p53-/- and p53+/-) mice (backcrossed for 12 generations with C57BL/6 mice) wild-type (p53+/+) to transient global by the three-vessel occlusion method. Despite similar severity of ischemia, as shown anoxic depolarization cortical blood flow, hippocampal cornus ammonis (CA)1 region was much more extensive p53+/+ than p53-/-...
The capacity to replace lost neurons after insults is retained by several regions of adult mammalian brains. However, it unknown how many actually and mature into region-specific functional restore brain function. In this paper, the authors asked whether neuronal regeneration could be achieved efficaciously growth factor treatment using a global ischemia model in rats, they analyzed long-term maturation processes.Rat modified 4-vessel occlusion was used induce consistent ischemic injury...
Object There have been significant advances in understanding the angioarchitecture of spinal dural arteriovenous fistulas (AVFs). However, major intradural retrograde venous drainage system has not investigated detail, including most proximal sites radiculomedullary veins as they connect to dura mater, which are final targets interruption both microsurgical and endovascular treatments. Methods Between April 1984 March 2011, 27 patients with 28 AVFs were treated for at authors' university...
In most patients with superficial siderosis of the CNS, exact source bleeding remains unknown because a lack objective surgical data. The authors herein describe case 58-year-old man CNS. patient also had spinal CSF leakage due to dural defect. Repair surgery for defect was performed using posterior laminoplasty transdural approach without fixation. During repair surgery, found be epidural vein around intraoperative and histological results present suggest that veins exposed represent...