A5077602174- Intracranial Aneurysms: Treatment and Complications
- Vascular Malformations Diagnosis and Treatment
- Meningioma and schwannoma management
- Spinal Cord Injury Research
- Mesenchymal stem cell research
- Spinal Fractures and Fixation Techniques
- Neurofibromatosis and Schwannoma Cases
- Moyamoya disease diagnosis and treatment
- Spinal Dysraphism and Malformations
- Head and Neck Surgical Oncology
- Nerve injury and regeneration
- Cerebrovascular and Carotid Artery Diseases
- Intraoperative Neuromonitoring and Anesthetic Effects
- Neurogenesis and neuroplasticity mechanisms
- Neurosurgical Procedures and Complications
- Spine and Intervertebral Disc Pathology
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurological Complications and Syndromes
- Glioma Diagnosis and Treatment
- Spinal Hematomas and Complications
- Cerebrospinal fluid and hydrocephalus
- Spaceflight effects on biology
- Acute Ischemic Stroke Management
- Bone Tumor Diagnosis and Treatments
- Transcranial Magnetic Stimulation Studies
Hiroshima University
2016-2025
Hiroshima City Asa Citizens Hospital
2019-2022
Hiroshima University Hospital
2020-2022
Shimane Prefectural Central Hospital
2006-2017
Onomichi General Hospital
2015
Ehime Prefectural Central Hospital
2003-2005
Unstable moyamoya disease, reasonably defined as cases exhibiting either rapid disease progression or repeated ischemic stroke, represents a challenge in the treatment of disease. Despite its overall efficacy, direct bypass for such unstable remains controversial terms safety. This study aims to reveal factors associated with and assess impact on postoperative silent symptomatic lesions.This retrospective cohort included both pediatric adult patients who had undergone 140 consecutive...
Craniocervical junction (CCJ) arteriovenous fistulas (AVFs) are treated using neurosurgical or endovascular options; however, there is still no consensus on the safest and most effective treatment. The present study compared treatment results of procedures for CCJ AVFs, specifically regarding retreatment, complications, outcomes.
Recently, cell-based therapy has gained significant attention for the treatment of central nervous system diseases. Although bone marrow stromal cells (BMSCs) are considered to have good engraftment potential, challenges due in vitro culturing, such as a decline their functional potency, been reported. Here, we investigated efficacy rat BMSCs (rBMSCs) cultured under simulated microgravity conditions, transplantation into model spinal cord injury (SCI).rBMSCs were two different conditions:...
OBJECTIVE A recent comparative analysis between neurosurgical and endovascular treatments for craniocervical junction (CCJ) arteriovenous fistulas (AVFs) revealed better treatment outcomes in the neurosurgery group than group. This finding was attributed to higher expected rate of ischemic complications (26% vs 7.7%, p = 0.037). The aim present study describe associated with CCJ AVFs. METHODS descriptive authorized by Neurospinal Society Japan. Data from 97 consecutive patients AVFs who...
We analyzed the cell characteristics, neuroprotective, and transplantation effects of human cranial bone-derived mesenchymal stem cells (hcMSCs) in ischemic stroke model rats compared with iliac (hiMSCs). The expressions brain-derived neurotrophic factor (BDNF) vascular endothelial growth (VEGF ) as factors were both MSCs. hiMSCs or hcMSCs intravenously administered into at 3 24 h after middle cerebral artery occlusion (MCAO) neurological function was evaluated. survival rate neuroblastoma ×...
Spinal arteriovenous shunts are rare vascular lesions and classified into 4 types (types I-IV). Due to rapid advances in neuroimaging, spinal epidural AVFs (edAVFs), which similar type I dural (dAVFs), have recently been increasingly reported. These 2 entities several important differences that influence the treatment strategy selected. The purposes of present study were compare angiographic clinical between edAVFs dAVFs provide strategies for based on a multicenter cohort.
Surgical lysis of the thickened arachnoid membrane is first choice treatment in spinal pathologies that cause flow disturbances or blockage CSF. However, it important to consider while extensive may temporarily provide a wide pathway for CSF, an lytic procedure later secondary adhesion. Thus, ideal proper extent be determined after careful analysis regional CSF flow. The authors report their limited experience with intraoperative visualization pathologies. Two patients dorsal web (DAW)...
OBJECT Spinal meningioma and schwannoma are the most common spinal intradural extramedullary tumors, differentiation of these 2 tumors by CT MRI has been a matter debate. The purpose this article is to present case series meningiomas showing unique imaging features: combination fan-shaped cord streak in tumor. authors termed former feature "ginkgo leaf sign" evaluated its diagnostic value. METHODS 7 cases having ginkgo sign. Thirty arising lateral or ventrolateral were studied evaluate value...
OBJECTIVE Elderly patients are particularly at risk for severe morbidity following surgery. Among the various factors, age and skull base location of meningioma known to be poor prognostic factors in The authors conducted this study analyze significant preoperative elderly with meningioma. METHODS A total 265 (≥ 65 years old) were surgically treated authors’ institute affiliated hospitals between 2000 2016, these cases reviewed. them, 57 evaluated. analyzed age, sex, Karnofsky Performance...
The functional disorders caused by central nervous system (CNS) diseases, such as ischemic stroke, are clinically incurable and current treatments have limited effects. Previous studies suggested that cell-based therapy using mesenchymal stem cells (MSCs) exerts therapeutic effects for stroke. In addition, the characteristics of MSCs may depend on their sources. Among derived tissues MSCs, we focused cranial bones originating from neural crest. We previously demonstrated neurogenic potential...
The purpose of the present study was to compare treatment success rates primary neurosurgical and endovascular treatments in patients with spinal dural arteriovenous fistulas (dAVFs).
Abstract Cell-based therapy using mesenchymal stem cells (MSCs) is a novel treatment strategy for spinal cord injury (SCI). MSCs can be isolated from various tissues, and their characteristics vary based on the source. However, reports demonstrating effect of transplanted rat cranial bone-derived (rcMSCs) SCI models are lacking. In this study, we determined transplanting rcMSCs in models. were established collected bone marrow bones. rats weight-drop method intravenously with at 24 h post...
The impact of adjuvant radiotherapy on overall survival (OS) and progression-free (PFS) patients with grade II spinal cord astrocytomas remains controversial. Additionally, the relationship between progression clinical deterioration after has not been well investigated.This study included 53 intramedullary treated by either subtotal, partial resection or open biopsy. Their performance status was assessed immediately before operation 1, 6, 12, 24, 60 months surgery Karnofsky Performance Scale...
Anterior condylar confluence (ACC) dural arteriovenous fistula (AVF) is a rare anomaly. We describe two cases of ACC AVF involving the anterior vein that were successfully treated with selective transvenous coil embolization. The first patient presented headache and right pulse-synchronous tinnitus, demonstrated abnormal flow medial to jugular bulb within hypoglossal canal on source image magnetic resonance angiography (MRA). Arterioangiography disclosed in this area, supplied mainly by...
Concurrent multiple tumors developing in the spinal cord are rare, except for genetic disorders, such as neurofibromatosis and von Hippel-Lindau disease. Furthermore, concurrent arising same level with discrete histopathology much rarer. We report two cases. Case 1: A 53-year-old man presented intracranial hemorrhage that manifested disturbed consciousness right hemiparesis. Magnetic resonance (MR) angiography demonstrated severe stenosis of terminal portion bilateral internal carotid...
Idiopathic hemorrhage in a syrinx is rare entity known as Gowers' intrasyringeal hemorrhage. Bleeding confined to the cavity causes severe, sometimes acute, neurological deficits. We report case of into preexisting lumbosacral associated with Chiari type I malformation.A 39-year-old female Noonan syndrome underwent foramen magnum decompression and cervical syrinx-subarachnoid shunt for malformation-associated syringomyelia 7 years ago. She presented progressive gait deterioration acute...
Cell-based therapies with mesenchymal stem cells (MSCs) are considered as promising strategies for spinal cord injury (SCI). MSCs have unique characteristics due to differences in the derived tissues. However, relatively few studies focused on therapeutic effects of from different In this study, adipose tissue-derived MSCs, bone marrow-derived and cranial bone-derived (cMSCs) chronic SCI model rats were compared. established collected tissue, marrow, bone. Neurotrophic factor expression each...