A5102906588- Cervical and Thoracic Myelopathy
- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Medical Imaging and Analysis
- Sarcoma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Musculoskeletal synovial abnormalities and treatments
- Spinal Cord Injury Research
- Pulmonary Hypertension Research and Treatments
- Cardiovascular Issues in Pregnancy
- Nerve Injury and Rehabilitation
- Musculoskeletal pain and rehabilitation
- Spinal Hematomas and Complications
- Inflammasome and immune disorders
- Tendon Structure and Treatment
- Scoliosis diagnosis and treatment
- Bone and Joint Diseases
- Osteoarthritis Treatment and Mechanisms
- S100 Proteins and Annexins
- Bone health and treatments
- Transcranial Magnetic Stimulation Studies
- Extracellular vesicles in disease
- Circadian rhythm and melatonin
- Nerve injury and regeneration
- Cardiac tumors and thrombi
Huashan Hospital
2016-2025
Fudan University
2016-2025
Clinical Orthopaedics and Related Research
2018-2019
Spinal cord injury (SCI) treatment remains a formidable challenge, as current therapeutic approaches provide only marginal relief and fail to reverse the underlying tissue damage. This study aims develop novel composite material combining enzymatic nanoparticles nerve growth factor (NGF) modulate immune microenvironment enhance SCI repair. CeMn (NP) NP-polyethylene glycol (PEG) nanozymes were synthesized via sol–gel reaction DSPE-mPEG modification. Transmission Electron Microscopy,...
Abstract Background Cartilaginous endplate (CEP) degeneration, which is an important contributor to intervertebral disc degeneration (IVDD), characterized by chondrocyte death. Accumulating evidence has revealed that dynamin-related protein 1 (Drp1)-mediated mitochondrial fission and dysfunction lead apoptosis during CEP IVDD. Exosomes are promising agents for the treatment of many diseases, including osteoporosis, osteosarcoma, osteoarthritis Despite their major success in drug delivery,...
Abstract Background Many factors have been reported to be associated with the prognosis of patients chondrosarcoma, but clinicians few tools estimate precisely an individual patient’s likelihood surviving illness. We therefore sought develop effective nomograms better survival chondrosarcoma. Questions/purposes (1) Which clinicopathologic features are independent prognostic for chondrosarcoma? (2) Can we a nomogram predict 3- and 5-year overall cancer-specific chondrosarcoma based on...
To establish a clinician-led guideline for the diagnosis and treatment of Hirayama disease (HD) using modified Delphi technique.Based on combination systematic review opinion ten experts, protocol consensus diagnosis, follow-up assessment HD was established. A 3-round survey then performed by more than 40 panelists from various countries world. Both levels evidence agreement were derived in all statements finial guideline.A total 47 experts 6 enrolled expert panel this study. Highly...
Monomelic amyotrophy (MMA) is a benign, self-limiting lower motor neuron disease. Optimal surgical strategies-discectomy decompression and fusion (DDF) or corpectomy (CDF)-for patients with aggravated symptoms (within 6 months of presentation) are controversial, particularly in those who ineligible for conventional treatment. These 2 methods anterior cervical MMA unwilling unable to wear collar long term were evaluated.Anterior performed 48 male between September 2007 2010. Patients randomly...
Retrospective analysis.To develop and validate nomograms to predict overall survival (OS) cancer-specific (CSS) of spinal chondrosarcoma patients.In this era personalized medicine, data those are available the patients still limited due rarity disease. Nomogram, which has been widely used in clinical oncology, could conveniently precisely outcome for individual patient.We retrospectively collected 450 from Surveillance, Epidemiology, End Results (SEER) database between 1984 2013. Univariate...
Abstract Background Although surgical resection or amputation has been the mainstay of localized chondrosarcoma management for many decades, its efficacy in patients with metastatic remains unknown, and likewise we do not know whether there are any tumor- patient-related factors associated better survival after surgery chondrosarcoma. Questions/purposes (1) Is primary tumor improved chondrosarcoma? (2) Which subgroups benefit more from terms survival? Methods We identified 200 222...
Spinal cord injury (SCI) remains a severe condition with an extremely high disability rate and complex pathophysiologic mechanisms. Pyroptosis, inflammatory form of cell death triggered by certain inflammasomes, has key role in variety diseases, including SCI. However, it is unclear whether microRNAs (miRNAs), novel regulators the SCI, are involved SCI-induced pyroptosis. Two GEO miRNA expression profiles (GSE158195 GSE90452) were downloaded, differentially expressed miRNAs analyzed...
Retrospective study. To evaluate the radiological characteristics of degenerative lumbar spondylolisthesis (DS) and analyze suitability oblique interbody fusion (OLIF) for different DS subtypes. OLIF has gained distinction its minimal invasiveness quicker recovery. Despite promising effectiveness in treating DS, variations patient necessitate precise surgical technique selection. The clinical radiographic (CARDS) classification aids identifying suitable From March 2020 to 2023, 100...
Study Design. Retrospective cohort study. Objective. This study aimed to analyze the correlation between VBQ scores and bone turnover markers in lumbar spine disorders. Summary of Background Data. Vertebral Bone Quality (VBQ) score is increasingly used assessment mineral density, quality profiles are closely related metabolism. However, level often overlooked clinical practice. Methods. We retrospectively analyzed data from 234 patients who underwent surgery. were evaluated using...
Because Hirayama disease is stereotyped as a self-limited in the absence of definite pathology, we investigated potential relationship between snake-eyes appearance (SEA) and to bring new perspective pathological process based on relevant radiological clinical evidence.A total 30 cases observed SEA were selected from 293 patients with constitute group, an equal number randomly remaining form non-SEA group. Cervical magnetic resonance imaging (MRI) was performed subsequently used measure...
ABSTRACT Background The treatment of spinal cord injury (SCI) is usually ineffective, because neuroinflammatory secondary an important cause the continuous development injury, and microglial pyroptosis step neuroinflammation. Recently, Bmal1, a core component circadian clock genes (CCGs), has been shown to play regulatory role in various tissues cells. However, it still unclear whether Bmal1 regulates after SCI. Methods In this study, we established vivo mouse model SCI using knockout (KO)...
To compare the biomechanical changes of adjacent segments between patients with Hirayama disease and non-pathological people after anterior cervical discectomy fusion (ACDF) operation, to explore optimal degree local lordosis reconstruction during surgery.A young male volunteer was recruited establish a three-dimensional finite element model lower spine based on CT data. By adjusting bony structures simulating operation process, models individuals before ACDF, different angles were...
Objectives To evaluate the biomechanical characteristics of endplate‐conformed cervical cages by finite element method ( FEM ) analysis and cadaver study. Methods Twelve specimens (C 2 –C 7 a model 3 were subjected to evaluations. In study, randomly assigned intact (I), (C) non‐conformed (N) groups with C 4–5 discs as treated segments. The morphologies individualized according CT images group fabricated 3‐D printer. wedge‐shaped similar commercially available grafts. Axial pre‐compression...