A5061999604- Musculoskeletal pain and rehabilitation
- Spine and Intervertebral Disc Pathology
- Pharmacological Effects of Natural Compounds
- Cholesterol and Lipid Metabolism
- Morinda citrifolia extract uses
- RNA Interference and Gene Delivery
- Veterinary Orthopedics and Neurology
- Healthcare and Venom Research
- Peroxisome Proliferator-Activated Receptors
- Cancer, Lipids, and Metabolism
- Plant Toxicity and Pharmacological Properties
- Medical Imaging and Analysis
- Curcumin's Biomedical Applications
- Apelin-related biomedical research
- DNA and Nucleic Acid Chemistry
- Osteoarthritis Treatment and Mechanisms
- Spinal Hematomas and Complications
- Drug Transport and Resistance Mechanisms
- Tendon Structure and Treatment
University of Illinois Chicago
2025
Huashan Hospital
2025
Fudan University
2025
The First Affiliated Hospital, Sun Yat-sen University
2021-2024
Sun Yat-sen University
2021-2024
Key Laboratory of Guangdong Province
2023
Abstract Intervertebral disc degeneration is a natural process during aging and leading cause of lower back pain. Here, we generate comprehensive atlas nucleus pulposus cells using single-cell RNA-seq analysis human tissues (three males four females, age 41.14 ± 18.01 years). We identify fibrotic late-stage characterized by upregulation serglycin expression which facilitate the local inflammatory response promoting infiltration cytokines macrophages. Finally, discover that daphnetin,...
Intervertebral disc degeneration (IVDD) is a main cause of low back pain, and inflammatory factors play key roles in its pathogenesis. Gremlin-1 (Grem1) was reported to induce an response other fields. This study aimed investigate the mechanisms Grem1 degenerative process intervertebral discs. Dysregulated genes were determined by analyzing microarray profiles. The expression 17 human samples (male:female = 9:8) rat models (n 5 each group) measured western blotting (WB), real-time...
ABSTRACT Although immune therapy has seen significant advances, the majority of breast and other solid tumors do not respond or quickly develop de novo resistance. One factor driving resistance is highly suppressive myeloid cells (MCs) such as macrophages. Previous work established clinical links between cholesterol cancer outcome, that MC function can be regulated through disruption in metabolism. Thus, we screened for proteins were expressed MCs, involved homeostasis whose expression was...
DNA G-quadruplex is a non-canonical secondary structure that could epigenetically regulate gene expression. To investigate the regulating role of G-quadruplex, we devised an integrating method to perform algorithm profiling and genome-wide analysis for dynamic change genomic RNA profiles in rat nucleus pulposus cells by inducing folding with multiple stabilizers. A group genes potentially regulated involved inflammation process has been identified. We found triggers response upregulating...
This study investigated the molecular mechanism by which acetylshikonin inhibits SOX4 expression via PI3K/Akt pathway to delay intervertebral disc degeneration (IVDD) and low back pain (LBP). Bulk RNA-seq, RT-qPCR, Western blot analysis, immunohistochemical staining, small interfering RNA (siSOX4), lentivirus (lentiv-SOX4
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