A5070988179- Colorectal Cancer Surgical Treatments
- RNA modifications and cancer
- Colorectal Cancer Screening and Detection
- Epigenetics and DNA Methylation
- Colorectal and Anal Carcinomas
- Colorectal Cancer Treatments and Studies
- Cancer Immunotherapy and Biomarkers
- Crystallization and Solubility Studies
- Radiomics and Machine Learning in Medical Imaging
- X-ray Diffraction in Crystallography
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Gastric Cancer Management and Outcomes
- Cancer-related gene regulation
- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- Inflammatory Biomarkers in Disease Prognosis
- Protein Tyrosine Phosphatases
- Cancer Cells and Metastasis
- RNA Interference and Gene Delivery
- AI in cancer detection
- DNA and Nucleic Acid Chemistry
- Ubiquitin and proteasome pathways
Sixth Affiliated Hospital of Sun Yat-sen University
2016-2025
Sun Yat-sen University
2016-2025
First Affiliated Hospital of Xiamen University
2025
Children's Hospital of Fudan University
2023
Key Laboratory of Guangdong Province
2022
National Natural Science Foundation of China
2019
Second Military Medical University
2019
University of California, Davis
2019
National Taiwan University Hospital
2009-2016
Abstract Chronological age is a risk factor for SARS-CoV-2 infection and severe COVID-19. Previous findings indicate that epigenetic could be altered in viral infection. However, the aging COVID-19 has not been well studied. In this study, DNA methylation of blood samples from 232 healthy individuals 413 patients profiled using EPIC array. Epigenetic ages each individual are determined by applying clocks telomere length estimator to profile individual. acceleration calculated compared...
Background Tumor-infiltrating lymphocytes (TILs), especially CD8+ TILs, can be used for predicting immunotherapy responsiveness and survival outcome. However, the evaluation of TILs currently relies on histopathological methodology with high variability. We therefore aimed to develop a DNA methylation signature (CD8+ MeTIL) that could evaluate immune response prognosis in colorectal cancer (CRC). Methods A MeTIL score was constructed by using T cell-specific differentially methylated...
More than ten randomized clinical trials are being tested to evaluate the efficacy, effectiveness and safety of a fasting-mimicking diet (FMD) combined with different antitumor agents.UMI-mRNA sequencing, Cell-cycle analysis, Label retention, metabolomics, Multilabeling et al. were used explore mechanisms. A tandem mRFP-GFP-tagged LC3B, Annexin-V-FITC Apoptosis, TUNEL, H&E, Ki-67 animal model was search for synergistic drugs.Here we showed that fasting or FMD retards tumor growth more...
Immunotherapy is beneficial for some colorectal cancer (CRC) patients, but immunosuppressive networks limit its effectiveness. Cancer-associatedfibroblasts (CAFs) are significant in immune escape and resistance toimmunotherapy, emphasizing the urgent need new treatment strategies. Flow cytometric, Western blotting, proteomics analysis, analysis of public database data, genetically modified cell line models, T coculture, crystal violetstaining, ELISA, metabonomic clinical tumour samples were...
Accurate and fast histological diagnosis of cancers is crucial for successful treatment. The deep learning-based approaches have assisted pathologists in efficient cancer diagnosis. remodeled microenvironment field cancerization may enable the cancer-specific features image non-cancer regions surrounding cancer, which provide additional information not available region to improve Here, we proposed a learning framework with fine-tuning target proportion towards tissues images gastric Through...
Here, we aim to investigate the molecular mechanism of regorafenib and verify potential druggable target for treatment hepatocellular carcinoma (HCC).HCC cell lines (PLC5, HepG2, Hep3B, SK-Hep1, HA59T) were used in vitro effect regorafenib. Phosphatase activity was analyzed HCC cells purified SHP-1 proteins. PLC5-bearing mice test therapeutic efficiency 20 40 mg/kg/d with ([Formula: see text] mice). The clinical relevance STAT3 signaling investigated 142 tumor samples from different patients...
Background Colony-stimulating factor 1 receptor (CSF1R), a classic tyrosine kinase receptor, has been identified as proto-oncogene in multiple cancers. The CSF1/CSF1R axis is essential for the survival and differentiation of M2-phenotype tumor-associated macrophages (M2 TAMs). However, we found here that CSF1R expression was abnormally down-regulated colorectal cancer (CRC), its biological functions underlying mechanisms have become elusive CRC progression. Methods class III kinases normal...
Background: Immune checkpoint inhibitor (ICI) treatment in patients with microsatellite instability-high/mismatch repair deficient (MSI-H/dMMR) tumors holds promise reshaping organ preservation rectal cancer. However, the benefits are accompanied by distinctive patterns of response, introducing a dilemma response evaluation for clinical decision-making. Patients and Methods: locally advanced cancer MSI-H/dMMR receiving neoadjuvant ICI (nICI) (n=13) matched chemoradiotherapy (nCRT; n=13) were...
Abstract Background N6‐methyladenosine (m6A) modification is an emerging epigenetic regulatory mechanism in tumourigenesis. Considering that AlkB homolog 5 (ALKBH5) a well‐described m6A demethylase previous enzyme assays, we aimed to investigate the role of methylation alteration conferred by disturbed ALKBH5 colorectal cancer (CRC) development. Methods Expression and its correlation with clinicopathological characteristics CRC were evaluated using prospectively maintained institutional...
Serum CEA has been widely used to screen for potential recurrent disease after resection in rectal cancer. However, the influence of baseline on performance recurrence surveillance needs be investigated.This longitudinal cohort study included 484 patients with nonmetastatic cancer from 18,013 a prospectively enrolled institutional database program colorectal disease. Baseline levels were determined before treatment, and CEA-based follow-up tests examinations applied treatment.A total 62.6%...
Abstract Background The current risk stratification system defined by clinicopathological features does not identify the of recurrence in early-stage (stage I-II) colorectal cancer (CRC) with sufficient accuracy. We aimed to investigate whether DNA methylation could serve as a novel biomarker for predicting prognosis CRC patients. Methods analyzed genome-wide status CpG loci using Infinium MethylationEPIC array run on primary tumor tissues and normal mucosa patients potential markers...
In recent decades, neoadjuvant therapy (NT) has been the standardized treatment for locally advanced rectal cancer (LARC). Approximately 8%-35% of patients with LARC who received NT were reported to have achieved a complete pathological response (pCR). If (PR) can be accurately predicted, these may not need surgery. addition, no after implies that tumor is destructive, resistant both chemotherapy and radiotherapy, prone having high metastatic potential. Therefore, developing accurate models...
BACKGROUNDCarcinoembryonic antigen (CEA) is a commonly used biomarker in colorectal cancer.However, controversy exists regarding the insufficient prognostic value of preoperative serum CEA alone rectal cancer.Here, we combined and maximum tumor diameter to correct level, which may better reflect malignancy cancer. AIMTo assess impact CEA/tumor size METHODSWe retrospectively reviewed 696 stage I III cancer patients who underwent curative resection from 2007 2012.These were randomly divided...
Diabetic foot ulcer (DFU) is a highly morbid complication in patients with diabetes mellitus, necessitating the development of innovative pharmaceuticals to address unmet medical needs. Sodium ion (Na
Abstract G-quadruplex (G4) is a noncanonical DNA secondary structure known to induce damage and regulate the expression of immune-related genes. We aim exploit G4 folding as treatment strategy trigger anti-tumor immune response. In this study, we observe that abundant genomic in epithelial cells coexists with increased infiltration CD8 + T colorectal cancer tissue. Furthermore, our data substantiate inhibitory effect ligand TMPyP4 on progression while concurrently stimulating immunity....
Abstract Background Intratumoral heterogeneity emerges from accumulating genetic and epigenetic changes during tumorigenesis, which may contribute to therapeutic failure drug resistance. However, the lack of a quick convenient approach determine intratumoral (eITH) limit application eITH in clinical settings. Here, we aimed develop tool that can evaluate using DNA methylation profiles bulk tumors. Methods Genomic three laser micro-dissected tumor regions, including digestive tract surface,...
BACKGROUND Colorectal cancer, one of the most common malignancies, is primarily treated through surgery. With widespread use laparoscopy, gastrointestinal reconstruction remains a key area research. The choice between intraperitoneal anastomosis (IA) and extraperitoneal (EA) subject considerable debate. This study uses isoperistaltic side-to-side (IISSA) with hand-sewn closure opening to evaluate its safety short-term outcomes. It hypothesized that this technique may offer better outcomes...
Colorectal cancer (CRC) is considered as an age-related disease, and cellular senescence (CS) plays a crucial role in development progression. Previous studies have shown the of epigenetic changes aging development, but RNA pseudouridine (Ψ) modification remains to be explored. Using bulk sequencing, CRC cells with low Ψ writers expression levels higher CS levels. We developed Psi Score for assessing transcriptomic profile regulation found that correlates CS. Furthermore, Psi-related may...