A5087288737- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Surgical Treatments
- Cancer-related molecular mechanisms research
- Nanoparticle-Based Drug Delivery
- Ferroptosis and cancer prognosis
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Screening and Detection
- Mycotoxins in Agriculture and Food
- MicroRNA in disease regulation
- Colorectal Cancer Treatments and Studies
- Microbial infections and disease research
- Colorectal and Anal Carcinomas
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- RNA modifications and cancer
- Genetic factors in colorectal cancer
- Antibiotic Resistance in Bacteria
- Anorectal Disease Treatments and Outcomes
- Immune Cell Function and Interaction
- Histone Deacetylase Inhibitors Research
- Immune cells in cancer
- Inflammatory Biomarkers in Disease Prognosis
- Antibiotic Use and Resistance
- Immunotherapy and Immune Responses
- Respiratory viral infections research
Shandong Provincial Hospital
2025
Shandong First Medical University
2025
Anhui Science and Technology University
2025
Anhui University of Science and Technology
2025
Ocean University of China
2023-2024
Xuan Wu Hospital of the Capital Medical University
2022-2024
Lanzhou University
2024
Lanzhou University Second Hospital
2024
Sun Yat-sen University
2012-2023
Sixth Affiliated Hospital of Sun Yat-sen University
2018-2023
The effect of corticosteroids on influenza A(H1N1)pdm09 viral pneumonia patients remains controversial, and the impact dosage has never been studied. Using data hospitalized adolescent adult with pneumonia, prospectively collected from 407 hospitals in mainland China, effects low-to-moderate-dose (25-150 mg d-1 ) high-dose (>150 30-day mortality, 60-day nosocomial infection were assessed multivariate Cox regression propensity score-matched case-control analysis. In total, 2141 (median age:...
Background Tumor-infiltrating lymphocytes (TILs), especially CD8+ TILs, can be used for predicting immunotherapy responsiveness and survival outcome. However, the evaluation of TILs currently relies on histopathological methodology with high variability. We therefore aimed to develop a DNA methylation signature (CD8+ MeTIL) that could evaluate immune response prognosis in colorectal cancer (CRC). Methods A MeTIL score was constructed by using T cell-specific differentially methylated...
Circular ATP binding cassette subfamily B member 10 (circABCB10) has been identified to have oncological functions in several tumors.However, the roles of circABCB10 rectal cancer remain unknown.The expression circABCB10, microRNA (miR)-326 and C-C motif chemokine ligand 5 (CCL5), apoptosis related-protein was detected using quantitative real-time polymerase chain reaction or western blot, respectively.Cell survival measured cell counting kit-8 assay flow cytometry.The accumulations...
Abstract: Lactoferrin (Lf) is a potential-targeting ligand for hepatocellular carcinoma (HCC) cells because of its specific binding with asialoglycoprotein receptor (ASGPR). In this present work, doxorubicin (DOX)-loaded, Lf-modified, polyethylene glycol (PEG)ylated liposome (Lf-PLS) system was developed, and targeting effect antitumor efficacy to HCC also explored. The DOX-loaded Lf-PLS had spherical or oval vesicles, mean particle size approximately 100 nm, an encapsulation efficiency 97%....
A lateral flow dual immunoassay (LFDIA) was developed for rapid quantitative detection of zearalenone (ZEN) and fumonisin B1 (FB1) in corn wheat samples on a single test strip. Two lines the control line nitrocellulose membrane were coated with ZEN FB1 conjugates goat anti-mouse IgG, respectively. Colloidal gold nanoparticles conjugated monoclonal antibodies against or FB1. The intensity analyzed by photometric strip reader to determine concentrations based calibration curves known versus...
Background There is limited data on the clinical outcome of patients with pandemic H1N1 (pH1N1) pneumonia who received oseltamivir treatment, especially when treatment was administered more than 48 hours after symptom onset. Methods During in 2009, a cohort pH1N1 influenza built China, and their information collected systematically, analyzed Cox models. Results 920 adults 541 children didn't receive corticosteroids were analyzed. In-hospital mortality higher did not antiviral therapy (18.2%)...
The chemoresistance of 5-fluorouracil (5-FU) limited the application chemotherapy in colorectal cancer (CRC) treatment. Herein, we aimed to uncover potential mechanism behind 5-FU resistance CRC cells.The abundance long noncoding RNA urothelial carcinoma associated 1 (lncRNA UCA1), microRNA-23b-3p (miR-23b-3p) and zinc finger protein 281 (ZNF281) was measured by quantitative real-time polymerase chain reaction (qRT-PCR) tissues cells. Western blot conducted examine autophagy-related...
T cells and B participate in the pathogenesis of COPD. Currently, NK NKT have gained increasing attention. In present study, 19 COPD patients 12 healthy nonsmokers (HNS) were recruited, their pulmonary function was assessed. The frequencies CD3(+) T, CD4(+) CD8(+) B, NK, NKT-like determined using flow cytometry. spontaneous inducible IFN- γ (+) or CD107a(+) as well activating inhibitory receptors also detected. potential association lymphocyte subsets with disease severity further analyzed....
A novel highly sensitive chemiluminescence immunoassay (CLIA) was developed to detect zearalenone in food samples by using both biotinylated conjugates and gold (Au) nanoparticles labeled with streptavidin–horseradish peroxidase for signal amplification. Biotinylated zearalenone–ovalbumin Au were synthesized separately. The concentrations of immunoreagents the reaction times these optimized improve performances analytical methods. For CLIA based on peroxidase, limit detection 0.008 ng/mL...
This study aims to explore the high-risk factors of carbapenem-resistant Enterobacteriaceae (CRE) infection hospitalised patients in departments. is a multicentre, retrospective study. CRE screening positive from 1 January 2016 31 December 2018 departments five tertiary first-class teaching hospitals Beijing collect patients' test specimen information, information and outcomes. The were divided into colonisation group an for comparative analysis. A logistic regression model was established...
Abstract Background Irrespective of microsatellite status, immune checkpoint inhibitor therapy shows superior efficacy in early-stage colorectal cancer (CRC) compared to advanced cases. The distinctions the tumor microenvironment (TME) and tertiary lymphoid structure (TLS) between early- advanced-stage CRC may represent a critical factor, yet remain incompletely elucidated. Methods We comprehensively analyzed single-cell RNA sequencing data, bulk transcription data pathological tissue...
A hypotoxic immunosorbent assay for the detection of zearalenone (ZEN) was developed, by identifying a single-stranded DNA (ssDNA) aptamer with high specificity and affinity ZEN monoclonal antibody (mAb-ZEN). ssDNA aptamers, which could mimic epitopes, were identified using modified systematic evolution ligands an exponential enrichment (SELEX) technique. The purified mAb-ZEN coated on microtiter plates as target recognized random oligonucleotide library. binding between aptamers during each...
This study was aimed to investigate serum metabolites in gastric cancer (GC) patients and their relationships with the prognosis of GC order find potential specific biomarkers for GC.Blood samples 125 unifocal at initial stage 38 healthy people recruited our hospital from September 2008 August 2009 were analyzed by using high performance liquid chromatography coupled electrospray ionization/quadrupole-time-of-flight mass spectrometry (HPLCESI/Q-TOFMS). Multiple statistical methods like...
Abstract This study aims to explore the ability of magnetic resonance imaging (MRI) in mucin 1 (MUC1) modified superparamagnetic iron oxide nanoparticle (SPION) targeting human pancreatic cancer (PC). The MUC1 target‐directed probe was prepared through conjugated SPION using chemical method assess its physiochemical characteristics, including hydration diameter, surface charge, and signal. cytotoxicity MUC1‐USPION verified by MTS assay. BxPC‐3 cultured with different concentrations. combined...
Bacillus licheniformis is a facultative anaerobe, gram-positive, endogenous, spore-forming bacillus. It included in probiotic preparation commonly used clinical practice and usually safe for oral administration. In this paper, we report two cases of bloodstream infection resulting from using B. preparations gastrointestinal bleeding. The results suggest that should be with caution people who are immunocompromised suffering severe= damage to the intestinal mucosal barrier.
Recent advances in spatial omics technologies enable situ molecular profiling while preserving context but face fundamental challenges achieving high-parameter and multi-omics co-profiling. Spatially resolving complementary panels or distinct layers across serial tissue sections circumvents technical trade-offs introduces the diagonal integration problem: reconstructing unified states when datasets lack shared features. To address this critical challenge, we present SpatialEx its extension...
Spodoptera frugiperda is a globally significant migratory agricultural pest that requires proactive monitoring. Understanding the molecular mechanisms underlying interactions between pathogenic microorganisms and S. crucial for enhancing effectiveness of microbial control agents against this pest. This study used transcriptome sequencing biology techniques on larvae infected by bacteria fungi to investigate composition regulatory its immune system. A total 598 immune-related genes were...
This study explores the molecular mechanisms underlying diapause in parasitoid wasp Telenomus remus (Nixon) (Hymenoptera: Platygastridae), a critical egg for biological control of invasive pest Spodoptera frugiperda (Smith) (Lepidoptera: Noctuidae). While effective management, T. faces limitations large-scale applications due to its short lifespan and low viability under storage conditions. Diapause, state developmental arrest, was successfully induced using photoperiod manipulation...