A5101550819- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- Invertebrate Immune Response Mechanisms
- Neurobiology and Insect Physiology Research
- Immunotherapy and Immune Responses
- Asthma and respiratory diseases
- Pediatric health and respiratory diseases
- Immune cells in cancer
- Aquaculture disease management and microbiota
- Cancer Immunotherapy and Biomarkers
- Monoclonal and Polyclonal Antibodies Research
- T-cell and B-cell Immunology
- Pleural and Pulmonary Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Amoebic Infections and Treatments
- Neuroscience and Neuropharmacology Research
- RNA modifications and cancer
- Traditional Chinese Medicine Analysis
- Lung Cancer Treatments and Mutations
- Ferroptosis and cancer prognosis
- Barrier Structure and Function Studies
- Paraquat toxicity studies and treatments
- Ocular and Laser Science Research
- Cancer-related gene regulation
- Inhalation and Respiratory Drug Delivery
First Affiliated Hospital Zhejiang University
2025
Shanghai University of Traditional Chinese Medicine
2022
First Hospital of Jilin University
2008-2020
Jilin University
2008-2020
Ningbo First Hospital
2020
Henan Provincial People's Hospital
2019
Ocean University of China
2018-2019
National Institutes for Food and Drug Control
2014
Stanford University
2001-2010
Guangdong Provincial Hospital of Traditional Chinese Medicine
2008
Gemcitabine has been used as first-line chemotherapy against lung cancer, but many patients experience cancer recurrence. Activation of anti-tumor immunity in vivo become an important way to prevent Anti-tumor immune responses are often dependent upon the immunogenicity tumors. In our study, we observed that low-dose gemcitabine treatment enhanced by increasing exposure calreticulin, high mobility group box 1 and upregulating expression NKG2D ligands. Further studies demonstrated increased...
Abstract Paraquat is a poisoning herbicide that primarily targets lung, leading to severe acute lung injury characterized by extensive neutrophil infiltration. However, the mechanisms underlying infiltration not clear. In this study, we demonstrated significance of signaling cascade from high-mobility group box 1 (HMGB1), Toll-like receptor 4 (TLR4), interleukin-23 (IL-23), and lastly IL-17A during paraquat-induced subsequent in mice. challenge significantly elevated serum levels IL-23,...
T cells and B participate in the pathogenesis of COPD. Currently, NK NKT have gained increasing attention. In present study, 19 COPD patients 12 healthy nonsmokers (HNS) were recruited, their pulmonary function was assessed. The frequencies CD3(+) T, CD4(+) CD8(+) B, NK, NKT-like determined using flow cytometry. spontaneous inducible IFN- γ (+) or CD107a(+) as well activating inhibitory receptors also detected. potential association lymphocyte subsets with disease severity further analyzed....
Minocycline, a tetracycline antibiotic, is now known to protect cells via an anti-inflammatory mechanism. We further explored this effect using in vitro model of ischemia-like injury neurons. Coculturing neurons with microglia, the brain's resident immune cell, modestly increased cell death due oxygen and glucose deprivation (OGD), compared alone. Treatment cocultures minocycline decreased level significantly lower than that or inhibitors various mediators, also led death. Importantly,...
Ubiquitin-conjugating enzyme E2S (UBE2S), a family of E2 protein in the ubiquitination process, is involved development various cancers. However, its role lung adenocarcinoma, has not been well elucidated. In this report, we attempted to investigate expression and function UBE2S adenocarcinoma. Up-regulation at mRNA, level, was observed human cancer tissues adenocarcinoma cells. Higher correlated with poorer prognosis patients. efficiently suppressed by lentivirus-mediated shRNA strategy...
The aim of this study was to investigate the role ubiquitin specific peptidase 10 (USP10/methyltransferase like 3 (METTL3)/C-X-C chemokine receptor type 4 (CXCR4) axis in immunotherapy castration-resistant prostate cancer (CRPC). Knockdown experiments were conducted CRPC cell lines assess effect targeting CXCR4 on proliferation invasion and migration. Coculture knockdown cells with THP1-M0 performed evaluate their impact macrophage polarization migration ability. With CD8+ T effects...
The aim of the present study was to investigate therapeutic effect Pulsatilla decoction (PD) on ulcerative colitis (UC) and elucidate its potential molecular mechanisms. C57BL/6 mice expressing natural killer (NK)1.1 were used as experimental animals in a model oxazolone‑induced established. Mice randomly divided into following five groups: i) PD group; ii) iii) IL‑13 intervention iv) 5‑aminosalicylic acid positive control v) negative group (equal volume saline gavage). A total 10 each...
Objective Macrophages are the infiltrate components of tuberculous pleural effusion (TPE). This study is aimed at examining role different subsets macrophages in fluid (PF) and peripheral blood (PB) from patients with new onset TPE. Methods The numbers PB PF CD163+, CD206+ CD115+ 25 TPE 17 healthy controls (HC) were determined by flow cytometry. concentrations serum cytokines cytometric bead array (CBA) enzyme-linked immunosorbentassay (ELISA). potential association between values clinical...
The aim of this study was to assess the underlying impact Tetramethylpyrazine (TMP), which is main activity compound Ligusticum chuanxiong Hort, on blood-brain barrier, inflammatory and nitrous oxide systems in a rat model lipopolysaccharide (LPS)-induced sepsis. SD rats were divided into control group, LPS treatment + TMP group. administered by tail vein injection. mortality experimental recorded during experiment. Rats sacrificed after 14 days. Peripheral blood collected expression levels...
The IL-33/sST2 axis is associated with inflammation and cardiac stress. This study examined the roles of serum other inflammatory cytokines in chronic obstructive pulmonary disease (COPD) patients, or without cor pulmonale (CCP). levels IL-33 sST2 36 COPD patients CCP, 42 cases 37 healthy controls (HCs) were analyzed by enzyme-linked immunosorbent assay. concentrations TNF-α, IL-1β, IL-6, IL-8, IL-10, IL-12 cytometric bead array. function was also determined. lower than CCP during acute...
Interleukin-28A (IL-28A) modulates CD11c+ dendritic cell (DC) function and promotes type 1T helper (Th1) differentiation, thus suppressing allergic airway diseases. However, the of IL-28A isoform IL-28B in these diseases remains largely unknown. In this study, we revealed a novel role inducing 1 immunity protecting against ovalbumin (OVA)-induced asthma mice. overexpression wild-type mice promoted natural killer (NK) polarization lung, leading to increased number interferon (IFN)-γ-producing...
Pulmonary carcinoma is the main cause of malignant pleural effusions (MPEs). However, there no satisfactory marker for diagnosing MPEs caused by pulmonary carcinoma. The purpose this study to assess clinical significance Lunx mRNA detection in carcinoma.A total 209 patients with were recruited. diagnosed cast-off cells, bronchoscopy, and biopsy. levels determined real-time PCR. PH, LDH, glucose, albumin, CEA also determined. Patients who accepted chemotherapy underwent before after first...
Foxp3(+) T cells regulate inflammation and tumorigenesis. However, little is known about the role of different subsets in malignant or tuberculous hydrothorax.The numbers CD4(+)CD25(+)Foxp3(+), CD4(+)CD25(-)Foxp3(+) levels some inflammatory cytokines patients with hydrothorax, healthy controls (HCs) were examined by flow cytometry ELISA. The potential association between Foxp3 + values clinical measures analyzed.The peripheral blood CD4(+)CD25(+)Foxp3(+) greater hydrothorax than HCs, but...
Most patients with lung adenocarcinoma (LUAD) present high recurrence rate and poor prognosis after therapy. Therefore, the purpose of this study was to identify prognostic factors involved in LUAD. Five microarray datasets (including GSE75037, GSE63459, GSE43458, GSE32863, GSE10072) were downloaded. After data preprocessing quality control, meta-analysis performed screen differentially expressed genes (DEGs) using MetaDE.ES method MetaDE package. Subsequently, network construction module...
Abstract Antibody repertoire sequencing (Ig-seq) has been widely used in studying humoral responses, with promising results. However, the promise of Ig-seq not yet fully realized, and key features antibody remain elusive or controversial. To clarify these features, we analyzed 2,152 high-quality heavy chain repertoires, representing 582 donors a total 360 million clones. Our study revealed that individuals exhibit very similar gene usage patterns for germline V, D, J genes 53 core V...