A5100615873- Extracellular vesicles in disease
- RNA modifications and cancer
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Lung Cancer Diagnosis and Treatment
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Spinal Cord Injury Research
- Lung Cancer Treatments and Mutations
- Cancer, Hypoxia, and Metabolism
- Pleural and Pulmonary Diseases
- Cell death mechanisms and regulation
- RNA Interference and Gene Delivery
- Helicobacter pylori-related gastroenterology studies
- Protein Tyrosine Phosphatases
- Cancer-related gene regulation
- Cancer-related Molecular Pathways
- Autophagy in Disease and Therapy
- Angiogenesis and VEGF in Cancer
- Biochemical and Molecular Research
- Ferroptosis and cancer prognosis
- Advances in Oncology and Radiotherapy
- Frailty in Older Adults
- Hedgehog Signaling Pathway Studies
- Gastric Cancer Management and Outcomes
Jilin University
2011-2025
Shandong University of Traditional Chinese Medicine
2020-2025
Sun Yat-sen University
2020-2025
Third Affiliated Hospital of Sun Yat-sen University
2021-2025
Beihua University
2024
Jiangxi University of Traditional Chinese Medicine
2024
First Hospital of Jilin University
2010-2024
Shandong Provincial Hospital
2022-2024
Shandong First Medical University
2022-2024
Nanjing Medical University
2014-2024
High functional heterogeneity of cancer cells poses a major challenge for research. Single-cell sequencing technology provides an unprecedented opportunity to decipher diverse states at single-cell resolution, and scRNA-seq datasets have been largely accumulated. This emphasizes the urgent need build dedicated resource decode single cells. Here, we developed CancerSEA (http://biocc.hrbmu.edu.cn/CancerSEA/ or http://202.97.205.69/CancerSEA/), first database that aims comprehensively explore...
Crizotinib, an inhibitor of anaplastic lymphoma kinase (ALK), has also recently shown efficacy in the treatment lung cancers with ROS1 translocations. Resistance to crizotinib developed a patient metastatic adenocarcinoma harboring CD74-ROS1 rearrangement who had initially dramatic response treatment. We performed biopsy resistant tumor and identified acquired mutation leading glycine-to-arginine substitution at codon 2032 domain. Although this does not lie gatekeeper residue, it confers...
Abstract Spinal cord injury (SCI) can cause severe irreversible motor dysfunction and even death. Neural stem cell (NSC) transplantation promote functional recovery after acute SCI in experimental animals, but numerous issues, including low-transplanted survival rate, de-differentiation, tumor formation need to be resolved before routine clinical application is feasible. Recent studies have shown that transplanted cells facilitate regeneration through release of paracrine factors. Small...
Abstract Background Spinal cord injury (SCI) is a catastrophic that can cause irreversible motor dysfunction with high disability. Exosomes participate in the transport of miRNAs and play an essential role intercellular communication via transfer genetic material. However, exosomes which derived from neurons, underlying mechanisms by they contribute to SCI remain unknown. Methods A contusive vivo model series vitro experiments were carried out explore therapeutic effects exosomes. Then,...
Pathologically, blood-spinal-cord-barrier (BSCB) disruption after spinal cord injury (SCI) leads to infiltration of numerous peripheral macrophages into injured areas and accumulation around newborn vessels. Among the leaked macrophages, M1-polarized are dominant play a crucial role throughout whole SCI process. The aim our study was investigate effects bone marrow-derived (M1-BMDMs) on vascular endothelial cells their underlying mechanism. Microvascular cell line bEnd.3 were treated with...
Abstract Drug delivery systems with high content of drug can minimize excipients administration, reduce side effects, improve therapeutic efficacy and/or promote patient compliance. However, engineering such is extremely challenging, as their loading capacity inherently limited by the compatibility between molecules and carrier materials. To mitigate drug-carrier limitation towards therapeutics encapsulation, we developed a sequential solidification strategy. In this strategy, precisely...
Abstract Switching of vascular smooth muscle cells ( VSMC s) from a contractile phenotype to an adverse proliferative is hallmark atherosclerosis or restenosis. However, the genetic modulators responsible for this switch have not been fully elucidated in humans nor they correlated with clinical abnormalities. This study investigated mechanisms involved phenotypic switching s at non‐defect areas aorta patients atherosclerosis. Aortic wall samples were obtained N = 53) and without 27)...
Ischemia-reperfusion injury is the second most common of spinal cord and has risk neurological dysfunction paralysis, which can seriously affect patient quality life. Salidroside (Sal) an active ingredient extracted from Herba Cistanche with a variety biological attributes such as antioxidant, antiapoptotic, neuroprotective activities. Moreover, Sal shown protective effect in ischemia-reperfusion liver, heart, brain, but its not been elucidated. Here, we demonstrated for first time that...
Spinal cord injury (SCI) is a devastating trauma that leads to irreversible motor and sensory dysfunction is, so far, without effective treatment. Recently, however, nano-sized extracellular vesicles derived from preconditioned mesenchymal stem cells (MSCs) have shown great promise in treating various diseases, including SCI. In this study, we investigated whether (MEVs) MSCs pretreated with melatonin (MT), which well recognized be useful Alzheimer's disease, non-small cell lung cancer,...
Circular RNAs (circRNAs) play critical roles in tumorigenesis and the progression of various cancers.We previously identified a novel upregulated circRNA, circBCBM1 (hsa_circ_0001944), context breast cancer brain metastasis.However, potential biological function molecular mechanism metastasis remain largely unknown.In this study, we confirmed that was stable cytoplasmic circRNA.Functionally, promoted proliferation migration 231-BR cells vitro growth vivo.Mechanistically, acted as an...
Spinal cord injury (SCI) is a severe traumatic disease which causes high disability and mortality rates. The molecular pathological features after spinal mainly involve the inflammatory response, microglial neuronal apoptosis, abnormal proliferation of astrocytes, formation glial scars. However, microenvironmental changes are complex, interactions between cells nerve remain unclear. Small extracellular vesicles (sEVs) may play key role in cell communication by transporting RNA, proteins,...
Arginase, which exists as the isoforms arginase I and II, catalyzes hydrolysis of arginine to ornithine urea. Ornithine is principal precursor for production polyamines, are required cell proliferation. Rat aortic smooth muscle cells (RASMC) contain constitutive I, inhibitors cause inhibition The objective this study was determine whether elevated expression in RASMC causes increased were stably transfected with either rat cDNA or a beta-galactosidase control plasmid. Western blots enzymatic...
The highly refractory nature of non-small cell lung cancer (NSCLC) to chemotherapeutic drugs is an important factor resulting in its poor prognosis. Recent studies have revealed that tumour necrosis alpha-induced protein 8 (TNFAIP8) involved various biological and pathological processes cells, but their underlying mechanisms ranging from development drug resistance not been fully elucidated. TNFAIP8 expression clinical NSCLC samples was examined through immunohistochemistry (IHC). After...
Neural stem cell-derived small extracellular vesicles (NSC-sEVs) play an important role in the repair of tissue damage. Our previous vitro and vivo studies found that preconditioning with NSC-sEVs promoted recovery functional behaviors following spinal cord injury by activating autophagy. However, underlying mechanisms for such observations remain unclear. In this study, we further explored which via We contain 14-3-3t protein, overexpression or knockdown enhanced decreased autophagy,...
Abstract Background Spinal cord injury (SCI) has a very disabling central nervous system impact but currently lacks effective treatment. Bone marrow-derived macrophages (BMDMs) are recruited to the injured area after SCI and participate in regulation of functional recovery with microglia. Previous studies have shown that M2 microglia-derived small extracellular vesicles (SEVs) neuroprotective effects, effects BMDM-derived sEVs (M2 BMDM-sEVs) not been reported Results In this study, we...
Leukemia cells rely on two nucleotide biosynthetic pathways, de novo and salvage, to produce dNTPs for DNA replication. Here, using metabolomic, proteomic, phosphoproteomic approaches, we show that inhibition of the replication stress sensing kinase ataxia telangiectasia Rad3-related protein (ATR) reduces output both salvage pathways by regulating activity their respective rate-limiting enzymes, ribonucleotide reductase (RNR) deoxycytidine (dCK), via distinct molecular mechanisms....