A5076929144- Tendon Structure and Treatment
- Advancements in Transdermal Drug Delivery
- RNA Interference and Gene Delivery
- Synthesis and properties of polymers
- Extracellular vesicles in disease
- Supramolecular Self-Assembly in Materials
- Immune cells in cancer
- Nerve injury and regeneration
- Knee injuries and reconstruction techniques
- Ion channel regulation and function
- Takotsubo Cardiomyopathy and Associated Phenomena
- Adipokines, Inflammation, and Metabolic Diseases
- Bee Products Chemical Analysis
- Cell Adhesion Molecules Research
- 3D Printing in Biomedical Research
- Advanced Drug Delivery Systems
- Cardiac electrophysiology and arrhythmias
- Innovative Microfluidic and Catalytic Techniques Innovation
- Exercise and Physiological Responses
- Atherosclerosis and Cardiovascular Diseases
- Polymer Surface Interaction Studies
- Epoxy Resin Curing Processes
- Elbow and Forearm Trauma Treatment
- Surfactants and Colloidal Systems
- Electrospun Nanofibers in Biomedical Applications
University of Helsinki
2020-2025
University of Urbino
2020
Ospedale dei Pellegrini
2020
Abstract Drug delivery systems with high content of drug can minimize excipients administration, reduce side effects, improve therapeutic efficacy and/or promote patient compliance. However, engineering such is extremely challenging, as their loading capacity inherently limited by the compatibility between molecules and carrier materials. To mitigate drug-carrier limitation towards therapeutics encapsulation, we developed a sequential solidification strategy. In this strategy, precisely...
Atherosclerosis still represents a major driver of cardiovascular diseases worldwide. Together with accumulation lipids in the plaque, inflammation is recognized as one key players formation and development atherosclerotic plaque. Systemic anti-inflammatory treatments are successful reducing disease burden, but correlated severe side effects, underlining need for targeted formulations. In this work, curcumin chosen payload model further loaded lignin-based nanoparticles (NPs). The NPs then...
Microfluidic on-chip production of polymeric hydrogel microspheres (MPs) can be designed for the loading different biologically active cargos and living cells. Among gelation strategies, ionically crosslinked generally show limited mechanical properties, meanwhile covalently often require use crosslinking agents or initiators with biocompatibility. Inverse electron demand Diels Alder (iEDDA) click chemistry is a promising covalent method fast kinetics, high chemoselectivity, efficiency no...
Tendinitis is a tendon disorder related to inflammation and pain, due an injury or overuse of the tissue, which hypocellular hypovascular, leading limited repair occurs in disorganized deposition extracellular matrix that leads scar formation fibrosis, ultimately resulting impaired integrity. Current conventional treatments are often ineffective, highlighting need for new therapeutic strategies. In this work, acetalated-dextran nanoparticles (AcDEX NPs) loaded with curcumin coated tannic...
Abstract Macrophages play a key role in the development of many diseases, like tissue injury, cancer, and autoimmune diseases. So far, single‐drug loaded nanoparticles are developed to target macrophages. Nevertheless, macrophage dysregulation can induce multiple conditions, i.e., inflammation fibrosis. Therefore, simultaneous codelivery small molecule drug interfering RNA (siRNA) for gene silencing may be beneficial modulate dysfunction. Herein, hybrid lipid–polymer (LPNs) coloaded with...
Amniotic epithelial stem cells (AEC) hold potential for tissue regeneration, especially through their conditioned medium (AEC-CM) due to immunomodulatory and regenerative effects. Nevertheless, advanced drug delivery systems such as hydrogels are needed enable clinical applications. Herein, an
Abstract In this study, a rationally designed nanocomposite (BUDPDA@MAP) composed of polydopamine (PDA) nanoparticle and anti‐inflammatory drug budesonide (BUD) encapsulated in pH‐responsive endosomolytic polymer (poly(butyl methacrylate‐ co ‐methacrylic acid) grafted acetalated dextran, denoted by MAP), is proposed. The uniform prepared using microfluidic device. At low endosomal pH (5.5), MAP destabilizes the membranes for cytoplasmic delivery PDA, releases BUD simultaneously, resulting...
Here, we introduce a pioneering approach in the domain of transdermal drug delivery systems (TDDS) by using microneedles (MNs) fabricated from amorphous solid dispersion comprising only model and an amphiphilic block copolymer to form nanoformulation upon MN dissolution. This presents most minimalistic maximize loading MN, reaching 40 wt.%. Using scanning electron microscopy, carefully examined morphology MNs across spectrum ratios, revealing remarkable consistency structure integrity....
Abstract A pioneering approach in the domain of transdermal drug delivery systems (TDDS) is introduced by using microneedles (MNs) fabricated from an amorphous solid dispersion comprising only a model and amphiphilic block copolymer to form nanoformulation upon MN dissolution. To maximize loading ensure consistent release, minimalist formulation that achieves 40 wt% loading, which significant improvement over existing methods, developed. Using scanning electron microscopy, morphology MNs...
Musculoskeletal diseases involving tissue injury comprise tendon, ligament, and muscle injury. Recently, macrophages have been identified as key players in the tendon repair process, but no therapeutic strategy dual drug delivery gene to has developed for targeting two main dysregulated aspects of tendinopathy, i.e., inflammation fibrosis. Herein, anti-inflammatory antifibrotic effects dual-loaded budesonide serpine1 siRNA lipid–polymer hybrid nanoparticles (LPNs) are evaluated murine human...
Summary The authors examine several reports of the literature concerning thyrotoxic dilated cardiomyopathy. In particular, it is pointed out that this clinical manifestation hyperthyroidism rare in readily diagnosed and properly treated hyperthyroidism. Case are analyzed comparatively. A case deriving from direct experience also presented. Learning points: Dilated cardiomyopathy has been reported as initial presentation only 6% patients although <1% developed severe LV dysfunction....
Tendinopathy involves the inflammation and degeneration of tendon due to repetitive strain injury. Current treatments primarily target resolution, yet they do not aim at tissue regeneration. In this study, a microfluidics approach is harnessed develop platform lipid nanoparticles (LNPs) loaded simultaneously with SMAD3 siRNA collagen I mRNA, aiming explore its potential dual antifibrotic regenerative effects in human tenocytes. The developed LNPs displayed size homogeneity colloidal...