A5108468354- Extraction and Separation Processes
- Hydrogels: synthesis, properties, applications
- Supramolecular Self-Assembly in Materials
- Nuclear and radioactivity studies
- Radioactive element chemistry and processing
- Hydraulic and Pneumatic Systems
- Field-Flow Fractionation Techniques
- Nuclear reactor physics and engineering
- Click Chemistry and Applications
- Advanced Drug Delivery Systems
- Radioactive contamination and transfer
- Advanced Polymer Synthesis and Characterization
- Nuclear Materials and Properties
- Pancreatic function and diabetes
- Innovative Microfluidic and Catalytic Techniques Innovation
- Cyclone Separators and Fluid Dynamics
- Surfactants and Colloidal Systems
- Process Optimization and Integration
- Graphite, nuclear technology, radiation studies
- Advancements in Transdermal Drug Delivery
- Synthesis and properties of polymers
- Tissue Engineering and Regenerative Medicine
- Pluripotent Stem Cells Research
- Electrohydrodynamics and Fluid Dynamics
- Mineral Processing and Grinding
University of Helsinki
2024-2025
Helsinki Art Museum
2025
Universitätsklinikum Würzburg
2023-2024
University of Würzburg
1970-2023
University of Kaiserslautern
1995
Argonne National Laboratory
1980-1983
Polymer self-assembly leading to cooling-induced hydrogel formation is relatively rare for synthetic polymers and typically relies on H-bonding between repeat units. Here, we describe a non-H-bonding mechanism reversible order-order (sphere-to-worm) transition related thermogelation of solutions polymer self-assemblies. A multitude complementary analytical tools allowed us reveal that significant fraction the hydrophobic hydrophilic units underlying block copolymer in close proximity gel...
Abstract Annular centrifugal contactors suitable for laboratory use in solvent extraction work have been designed and tested both hydraulic performance mass-transfer efficiency. The 2-cm nominal flow rates of 80 mL/min efficiencies at least 85% as measured by the uranium. These well organic-to-aqueous (O/A) ratios greater than 0.8. Multistage units allow proposed sheets to be on a continuous basis laboratory. Scale-up larger plant-size is straightforward.
Abstract A dimensionless dispersion number was developed to characterize liquid‐liquid dispersions created in turbulent Couette flow with respect their subsequent coalescence a settling zone. For given solvent pair and continuous phase, the is relatively constant over wide range of operating dimensional parameters. Because this, can be used for design scale‐up liquid extraction equipment discrete stages.
Polymer lipids (PLs) are essential components of liposomes and lipid nanoparticles (LNPs) for drug gene delivery, providing colloidal stabilization defining the biological interface. While poly(ethylene glycol) (PEG)‐based PLs current standard, they suspected to be responsible rare adverse reactions, e. g. LNP‐based Covid‐19 vaccines. Therefore, based on alternative stealth polymers being intensively investigated their use in LNPs. However, often lack comparability due different synthesis...
Polymer lipids (PLs) are essential components of liposomes and lipid nanoparticles (LNPs) for drug gene delivery, providing colloidal stabilization defining the biological interface. While poly(ethylene glycol) (PEG)‐based PLs current standard, they suspected to be responsible rare adverse reactions, e. g. LNP‐based Covid‐19 vaccines. Therefore, based on alternative stealth polymers being intensively investigated their use in LNPs. However, often lack comparability due different synthesis...
Here, we introduce a pioneering approach in the domain of transdermal drug delivery systems (TDDS) by using microneedles (MNs) fabricated from amorphous solid dispersion comprising only model and an amphiphilic block copolymer to form nanoformulation upon MN dissolution. This presents most minimalistic maximize loading MN, reaching 40 wt.%. Using scanning electron microscopy, carefully examined morphology MNs across spectrum ratios, revealing remarkable consistency structure integrity....
Abstract A pioneering approach in the domain of transdermal drug delivery systems (TDDS) is introduced by using microneedles (MNs) fabricated from an amorphous solid dispersion comprising only a model and amphiphilic block copolymer to form nanoformulation upon MN dissolution. To maximize loading ensure consistent release, minimalist formulation that achieves 40 wt% loading, which significant improvement over existing methods, developed. Using scanning electron microscopy, morphology MNs...
Previously, the cooling-induced thermogelation of an amphiphilic ABA type triblock copolymer comprising a central poly(2-phenyl-2-oxazine) (pPheOzi) block flanked by hydrophilic poly(2-methyl-2-oxazoline) (pMeOx) blocks was reported. This process is based on unusual, transition in polymer self-assembly from spherical to worm-like micelles, for which PheOzi units are decisive. Here, we investigate this phenomenon further introducing new variants pPheOzi-based copolymers explore variability...
Abstract Operation with three liquid phases was demonstrated in a staged liquid-liquid contactor. The possibility that could be handled contactor normally used two initially established using laboratory batch test. were obtained thorium flow sheet having high concentrations of both acid and thorium. To analyze the test, concept dimensionless dispersion number for use extended so it applied to phases.
Polymer lipids (PLs) are essential components of liposomes and lipid nanoparticles (LNPs) for drug gene delivery, providing colloidal stabilization defining the biological interface. While poly(ethylene glycol) (PEG)-based PLs current standard, they suspected to be responsible rare adverse reactions, e. g. LNP-based Covid-19 vaccines. Therefore, based on alternative stealth polymers being intensively investigated their use in LNPs. However, often lack comparability due different synthesis...
Previously, the cooling-induced thermogelation of an amphiphilic ABA type triblock copolymer comprising a central poly(2-phenyl-2-oxazine) (pPheOzi) block flanked by hydrophilic poly(2-methyl-2-oxazoline) (pMeOx) blocks was reported. This process is based on...
Thermoresponsive hydrogel formation upon cooling in aqueous media is rarely described for synthetic polymers the literature. However, if sol-gel transition occurs physiologically relevant range (0-40 °C), there are many possible applications areas such as drug delivery and biofabrication. Here, we describe a new mechanism of thermally induced order-order polymer self-assembly an ABA triblock consisting hydrophilic A blocks hydrophobic aromatic B block. Small-angle X-ray scattering confirmed...
<title>Abstract</title> Stem cell-derived β-cells (SC-BCs) display a potential source for curing diabetes. Up to now, <italic>in vitro</italic> generated SC-BCs an immature phenotype and lack important features in comparison their bona-fide counterparts. Transplantation into living animal promotes maturation, indicating that components of the vivo</italic> microenvironment trigger final development. Here, we investigated whether cues pancreas specific extracellular matrix (ECM) can improve...