A5100448134- melanin and skin pigmentation
- Extracellular vesicles in disease
- Electrocatalysts for Energy Conversion
- Spinal Cord Injury Research
- Advanced Photocatalysis Techniques
- Cancer-related molecular mechanisms research
- Reproductive Biology and Fertility
- Copper-based nanomaterials and applications
- Peptidase Inhibition and Analysis
- Circular RNAs in diseases
- Biochemical Analysis and Sensing Techniques
- Wound Healing and Treatments
- Dendrimers and Hyperbranched Polymers
- Laser Applications in Dentistry and Medicine
- Advanced biosensing and bioanalysis techniques
- Biomedical Research and Pathophysiology
- RNA Interference and Gene Delivery
- Signaling Pathways in Disease
- Ziziphus Jujuba Studies and Applications
- Hydrogen Storage and Materials
- Chronic Kidney Disease and Diabetes
- Medicinal Plants and Neuroprotection
- Atherosclerosis and Cardiovascular Diseases
- Iron Metabolism and Disorders
- Protease and Inhibitor Mechanisms
Nanjing Medical University
2015-2025
Northwest University
2021
Jiangsu Province Hospital
2019
Nanjing Maternity and Child Health Care Hospital
2017
Zhengzhou University
2013
Abstract Background Spinal cord injury (SCI) is a catastrophic that can cause irreversible motor dysfunction with high disability. Exosomes participate in the transport of miRNAs and play an essential role intercellular communication via transfer genetic material. However, exosomes which derived from neurons, underlying mechanisms by they contribute to SCI remain unknown. Methods A contusive vivo model series vitro experiments were carried out explore therapeutic effects exosomes. Then,...
Pathologically, blood-spinal-cord-barrier (BSCB) disruption after spinal cord injury (SCI) leads to infiltration of numerous peripheral macrophages into injured areas and accumulation around newborn vessels. Among the leaked macrophages, M1-polarized are dominant play a crucial role throughout whole SCI process. The aim our study was investigate effects bone marrow-derived (M1-BMDMs) on vascular endothelial cells their underlying mechanism. Microvascular cell line bEnd.3 were treated with...
Increasing evidence indicates that lymphocyte cytosolic protein 1 (LCP1) overexpression contributes to tumor progression; however, its role in osteosarcoma (OS) remains unclear. We aimed investigate the potential effect of LCP1 OS and underlying mechanisms. first demonstrated is upregulated cell lines tissues. Then, we found aberrant expression could induce proliferation metastasis cells vitro vivo by destabilizing neuregulin receptor degradation protein-1 (Nrdp1) subsequently activating...
Abstract Antibody‐based medicines and nanomedicines are very promising for cancer therapy due to the high specificity efficacy of antibodies. However, antibody‐drug conjugates antibody‐modified nanomaterials frequently suffer from low drug loading loss functions covalent modification antibody. A novel versatile strategy prepare supramolecular by coassembly an affibody (antiHER2) drug‐peptide amphiphiles is reported here. During enzyme‐instructed self‐assembly process, amphiphile can...
Thisstudy compared the ultrastructural differences of term placentae from human pregnancies resulting assisted reproductive technology (ART) with spontaneous pregnancies. Term were taken women who had undergone an ART procedure (n = 8) and matched a pregnancy (controls, n 15). Using light microscopy (LM) transmission-electron (TEM), terminal villi evaluated respect to placental blood barrier, fetal capillaries, villous stroma, as well cytotrophoblasts syncytiotrophoblasts (ST) along their...
// Yuting Ling 1 , Qingli Gong Xixi Xiong Li Sun Wene Zhao 2 Wenyuan Zhu and Yan Lu Department of Dermatology, The First Affiliated Hospital Nanjing Medical University, Nanjing, Jiangsu Province, 210029, P.R. China Analysis Testing Center, Correspondence to: Lu, email: luyan6289@163.com Keywords: madecassoside, oxidative stress, autophagy, mitochondria, vitiligo Received: December 28, 2016 Accepted: April 19, 2017 Published: May 07, ABSTRACT Background: Centella asiatica (L.) Urb. is a...
Abstract Background To reveal detailed histopathological changes, virus distributions, immunologic properties and multi‐omic features caused by SARS‐CoV‐2 in the explanted lungs from world's first successful lung transplantation of a COVID‐19 patient. Materials methods A total 36 samples were collected lungs. Histopathological distribution observed optical microscope transmission electron (TEM). Immune cells detected flow cytometry immunohistochemistry. Transcriptome proteome approaches used...
Although mesoporous materials and magnetic are used to enrich glycopeptides, sharing both structures properties have not been reported for glycopeptide analyses. Here we prepared boronic acid-modified Fe3O4@mTiO2 microspheres by covalent binding of acid molecules onto the surfaces silanized microspheres. The final particles (denoted as B-Fe3O4@mTiO2) showed a typical hysteresis curve, indicating superparamagnetic behavior; meanwhile, their sizes did change in spite reduction surface area...
MaxQuant is a proteomic software widely used for large-scale tandem mass spectrometry data. We have designed and developed an enhanced result reporting tool MaxQuant, named as MaxReport. This can optimize the results of provide additional functions interpretation. MaxReport generate report tables protein N-terminal modifications. It also supports isobaric labelling based relative quantification at protein, peptide or site level. To obtain overview results, performs general descriptive...
Abstract Background Multiple myeloma (MM) is the second most common hematological malignancy. An overwhelming majority of patients with MM progress to serious osteolytic bone disease. Aminoacyl‐tRNA synthetase‐interacting multifunctional protein 1 (AIMP1) participates in several steps during cancer development and osteoclast differentiation. This study aimed explore its role MM. Methods The gene expression profiling cohorts were applied determine AIMP1 association patient prognosis....
Glomerulonephritis is the major cause of chronic kidney disease characterized by mesangial cell proliferation and extracellular matrix deposition. The aim this study was to investigate effects Lycium barbarum polysaccharides (LBPs) on anti-Thy 1 nephritis rats explore protective mechanism LBPs. After model glomerulonephritis created injecting anti-thymocyte serum (ATS), were treated with enalapril or LBPs for 8 weeks. therapeutic effect evaluated detection renal-related biochemical...
Arabidopsis cyclophilin38 (CYP38) is a thylakoid lumen protein critial for PSII assembly and maintenance, its C-terminal region serves as the target binding domain. We hypothesized that four conserved residues (R290, F294, Q372, F374) in domain are critical structure function of CYP38. In yeast two-hybrid pull-down assays, CYP38s with single-sited mutations (R290A, F294A, Q372A, or F374A) did not interact CP47 E-loop wild-type contrast, CYP38 R290A/F294A/Q372A/F374A quadruple mutation could...
Spermatogonial stem cells (SSCs) are exquisitely regulated to reach a balance between proliferation and differentiation in the niche of seminiferous epithelium. Several extrinsic factors such as GDNF reported switch transition, activating various intrinsic signaling pathways. Transcriptomics analysis could provide comprehensive landscape gene expression regulation. Here, we reanalyzed previously published transcriptome two cell types (standing for self-renewing differentiating SSCs...
Objective: To explore whether shikonin can alleviate vascular leakage in burn wounds, inhibit skin inflammation, and exert protective effects on skin. Methods: A mouse wound model was routinely established, fluorescent microspheres were injected through the tail vein 2 h before sampling to characterize degree of leakage. Dorsal obtained by surgical dissection embedded OCT, frozen sections prepared. CD31 immunofluorescence used determine distribution blood vessels burnt skin, Ly6G staining...