A5100402313- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Circular RNAs in diseases
- Chronic Kidney Disease and Diabetes
- Autophagy in Disease and Therapy
- Epigenetics and DNA Methylation
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Food composition and properties
- NF-κB Signaling Pathways
- Extracellular vesicles in disease
- Cancer-related gene regulation
- interferon and immune responses
- Microbial Metabolites in Food Biotechnology
- Inflammasome and immune disorders
- Dialysis and Renal Disease Management
- Sodium Intake and Health
- Advanced Cellulose Research Studies
- Renal Diseases and Glomerulopathies
- Adipose Tissue and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Fibroblast Growth Factor Research
- Menopause: Health Impacts and Treatments
Queen Mary Hospital
2020-2024
University of Hong Kong
2000-2024
Southern Medical University
2015-2024
Sichuan Agricultural University
2024
Sun Yat-sen University
2013-2024
Hubei University of Arts and Science
2024
Xiangyang Central Hospital
2024
Third Affiliated Hospital of Zhengzhou University
2018-2024
Southeast University
2024
The First Affiliated Hospital, Sun Yat-sen University
2024
Abstract Purpose: Aberrant activation of the Wnt/β-catenin signaling pathway is associated with multiple tumors including colorectal cancer (CRC). WNT5A a member nontransforming Wnt protein family, whose role in tumorigenesis still ambiguous. We investigated its epigenetic alteration CRCs. Experimental Design: examined expression and methylation normal colon, CRC cell lines, tumors. also evaluated tumor-suppressive function modulation to cells. Results: silenced most lines due promoter...
The P2X7 receptor regulates cell growth through mediation of apoptosis. Low level expression has been linked to cancer development because tumor cells harboring a defective mechanism can escape pro-apoptotic control. microRNAs (miRNAs) function as negative regulators post-transcriptional gene expression, playing major roles in cellular differentiation, proliferation, and metastasis. In this study, we found that miR-150 was over-expressed breast lines tissues. these lines, blocking the action...
Abstract Purpose To identify an immune‐related long noncoding RNA (lncRNA) signature with potential prognostic value for patients pancreatic cancer. Methods Pancreatic cancer samples available clinical information and whole genomic mRNA expression data obtained from The Cancer Genome Atlas (TCGA) were enrolled in our research. immune score of each sample was calculated according to the level genes used most promising lncRNAs. According risk developed screened lncRNAs, high‐ low‐risk groups...
Abstract Background The zinc transporters Zrt- and Irt-related protein (ZIP/SLC39) are overexpressed in human tumors correlate with poor prognosis; however, their contributions to carcinogenesis chemoresistance osteosarcoma (OS) remain unclear. Methods We collected 64 OS patient tissues ( n = 12) or without 52) chemotherapy. expression levels of ZIP10 were measured by immunohistochemistry applied prognostic analysis. was knocked down cell lines explore its effect on proliferation...
Acute kidney injury (AKI) is common in hospitalized patients and associated with high mortality. Inflammation plays a key role the pathophysiology of AKI. Long non-coding RNAs (lncRNAs) are increasingly recognized as regulators inflammatory immune response, but its AKI remains unclear.
Closely located at the tumor suppressor locus 16q22.1, CKLF-like MARVEL transmembrane domain-containing member 3 and 4 (CMTM3 CMTM4) encode two CMTM family proteins, which link chemokines transmembrane-4 superfamily. In contrast to broad expression of both CMTM3 CMTM4 in normal human adult tissues, only is silenced or down-regulated common carcinoma (gastric, breast, nasopharyngeal, esophageal, colon) cell lines primary tumors. methylation was not detected epithelial with weak present 5 35...
Apoptosis, one of the major causes podocyte loss, has been reported to have a vital role in diabetic nephropathy (DN) pathogenesis, and understanding mechanisms underlying regulation apoptosis is crucial. Metadherin (MTDH) an important oncogene, which overexpressed most cancers responsible for apoptosis, metastasis, poor patient survival. Here we show that expression levels Mtdh phosphorylated p38 mitogen-activated protein kinase (MAPK) are significantly increased, whereas those microRNA-30...
Long non-coding RNAs (lncRNAs) play important roles in the progression of cervical cancer (CC). However, and underlying molecular mechanisms lncRNAs CC remain unclear. In current study, we discovered a new lncRNA MIR210HG which was upregulated tissues through microarray. The upregulation associated with advanced FIGO stage, metastasis, poor prognosis patients. Function assays showed that inhibition significantly suppressed proliferation, invasion, epithelial-mesenchymal transition (EMT)...
Abstract Mitochondria take part in a network of intracellular processes that regulate homeostasis. Defects mitochondrial function are key pathophysiological changes during AKI. Although Wnt/β-catenin signaling mediates dysfunction chronic kidney fibrosis, little is known the influence β-catenin on To decipher this interaction, we generated an inducible mouse model tubule-specific overexpression (TubCat), and depletion (TubcatKO), induced septic AKI these mice with lipopolysaccharide (LPS)...
Abstract Cocaine dependence involves in the brain's reward circuit as well nucleus accumbens (NAc), a key region of mesolimbic dopamine pathway. Many studies have documented altered expression genes and identified transcription factor networks epigenetic processes that are fundamental to cocaine addiction. However, all these investigations focused on mRNA encoding genes, which may not always reflect involvement long non‐coding RNAs (lncRNAs), has been implied broad range biological complex...
Impurity doping plays a critical role in altering the properties of target nanomaterials terms designed morphologies, crystal structures, and functionalities. In this work, we have performed comprehensive investigation effect Li+ on morphology, structure, upconversion luminescence NaYF4:Yb/Er nanocrystals. Different sources, e.g., LiOA LiOH, were used concentration varied from 0 to 100 mol%. The final product changes hexagonal mixture cubic tetragonal LiYF4:Yb/Er, finally pure LiYF4:Yb/Er....
Micheliolide (MCL), derived from parthenolide (PTL), is known for its antioxidant and anti-inflammatory effects has multiple roles in inflammatory diseases tumours. To investigate effect on renal disease, we intragastrically administrated DMAMCL, a dimethylamino Michael adduct of MCL vivo use, two fibrosis models–the unilateral ureteral occlusion (UUO) model an ischaemia-reperfusion injury (IRI) used combination with transforming growth factor beta 1 (TGF-β1) mouse tubular epithelial cells...
Background: Most tumors have an enhanced glycolysis flux, even when oxygen is available, called the aerobic or Warburg effect.Metabolic reprogramming promotes cancer progression, and related to tumorigenesis.However, it not clear whether observed metabolic changes act as a driver bystander in development.Methods: In this study, characteristics of oral precancerous cells cervical lesions were analyzed by metabolomics, expression glycolytic enzymes was evaluated RT-PCR Western blot...
The comprehensive studies of Sc<sup>3+</sup>-induced morphology, phase structure, and upconversion luminescence modulation YF<sub>3</sub>:Yb/Er nanocrystals have been reported.
Abstract Protease-activated receptor (PAR)-1 has emerged as a key profibrotic player in various organs including kidney. PAR-1 activation leads to deposition of extracellular matrix (ECM) proteins the tubulointerstitium and induction epithelial–mesenchymal transition (EMT) during renal fibrosis. We tested anti-fibrotic potential vorapaxar, clinically approved antagonist for cardiovascular protection, an experimental kidney fibrosis model unilateral ureteral obstruction (UUO) AKI-to-chronic...