A5101481719- MicroRNA in disease regulation
- Breast Cancer Treatment Studies
- RNA Interference and Gene Delivery
- HER2/EGFR in Cancer Research
- Cancer Cells and Metastasis
- Cancer Diagnosis and Treatment
- Fibroblast Growth Factor Research
- Cancer-related molecular mechanisms research
- Breast Lesions and Carcinomas
- Kruppel-like factors research
- Cancer Treatment and Pharmacology
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Chemokine receptors and signaling
- Immune Cell Function and Interaction
- Immune cells in cancer
- Estrogen and related hormone effects
- Metastasis and carcinoma case studies
- Peptidase Inhibition and Analysis
- Breast Implant and Reconstruction
- Advanced Breast Cancer Therapies
- Cancer, Stress, Anesthesia, and Immune Response
- Radiomics and Machine Learning in Medical Imaging
- Cancer and Skin Lesions
- Hepatitis B Virus Studies
Sun Yat-sen Memorial Hospital
2014-2025
Sun Yat-sen University
2014-2025
Shandong First Medical University
2025
Shandong Tumor Hospital
2025
Changzhi Medical College
2023
Breast Center
2011-2017
Memorial Hospital of South Bend
2010-2015
Trastuzumab resistance emerges to be a major issue in anti-human epidermal growth factor receptor 2 (HER2) therapy for breast cancers. Here, we demonstrated that miR-21 expression was up-regulated and its function elevated HER2(+) BT474, SKBR3, MDA-MB-453 cancer cells are induced acquire trastuzumab by long-term exposure the antibody, whereas protein of PTEN gene, target, reduced. Blocking action with antisense oligonucleotides re-sensitized resistant therapeutic activities inducing arrest,...
Tumor-initiating cells are resistant to chemotherapy, but how microRNAs play a role in regulating drug resistance of breast tumor-initiating (BT-IC) needs be clarified.
Abstract Macrophages play a pivotal role in tissue fibrogenesis, which underlies the pathogenesis of many end-stage chronic inflammatory diseases. MicroRNAs are key regulators immune cell functions, but their roles macrophage’s fibrogenesis have not been characterized. Here we show that IL-4 and IL-13 induce miR-142-5p downregulate miR-130a-3p macrophages; these changes sustain profibrogenic effect macrophages. In vitro , mimic prolongs STAT6 phosphorylation by targeting its negative...
The origin of tumor-infiltrating Tregs, critical mediators tumor immunosuppression, is unclear. Here, we show that naive CD4+ T cells and Tregs in human breast cancer have overlapping TCR repertoires, while hardly overlap with circulating suggesting intratumoral mainly develop from situ rather than recruited Tregs. Furthermore, the abundance closely correlated, both indicating poor prognosis for patients. Naive adhere to slices proportion CCL18-producing macrophages. Moreover, adoptively...
The P2X7 receptor regulates cell growth through mediation of apoptosis. Low level expression has been linked to cancer development because tumor cells harboring a defective mechanism can escape pro-apoptotic control. microRNAs (miRNAs) function as negative regulators post-transcriptional gene expression, playing major roles in cellular differentiation, proliferation, and metastasis. In this study, we found that miR-150 was over-expressed breast lines tissues. these lines, blocking the action...
TGF-β plays a central role in mediating epithelial-mesenchymal transition (EMT) by activating the Smad pathway. In addition, accumulating evidence suggests that TGF-β-induced EMT is NF-κB-dependent various cancer types. However, it largely unclear if NF-κB mediates breast cancer, and this mediation occurs, regulatory mechanisms are unknown. our study, we found activates Inhibition of signaling markedly abrogates EMT. By studying mechanism signaling, lncRNA NKILA was upregulated essential for...
Purpose The peripheral hematologic parameters of patients can be prognostic for many malignant tumors, including breast cancer, although their value has not been investigated among the different molecular subtypes cancer. purpose this study was to examine significance neutrophil-to-lymphocyte ratio (NLR) and lymphocyte-to-monocyte (LMR) in Methods A retrospective cohort 1570 operable cancer recruited between January 2000 December 2010. counts neutrophils, lymphocytes, monocytes platelets...
Trastuzumab is a standard treatment for HER2-positive (HER2+) breast cancer, but some patients are refractory to the therapy. MicroRNAs (miRNAs) have been used predict therapeutic effects various cancers, whether miRNAs can serve as biomarkers HER2+ metastatic cancer (MBC) remains unclear. Using miRNA microarray, we identify 13 differentially expressed in serum of MBC with distinct response trastuzumab, and four selected construct signature survival using LASSO model. Further, our data show...
The RNA-binding protein Lin28 is known to promote malignancy by inhibiting the biogenesis of let-7, which functions as a tumor suppressor. However, role Lin28/let-7 axis in epithelial-to-mesenchymal transition (EMT) and stemness breast cancer has not been clearly expatiated. In our previous study, we demonstrated that let-7 regulates self-renewal tumorigenicity stem cells. present was highly expressed mesenchymal (M) type cells (MDA-MB-231 SK-3rd), but it barely detectable epithelial (E)...
// Junjun Chu 1, 2, 3 , Yinghua Zhu 2 Yujie Liu Lijuan Sun Xiaobin Lv Yanqin Wu Pengnan Hu Fengxi Su Chang Gong Erwei Song Bodu Qiang 1 Breast Tumor Center, Yat-sen Memorial Hospital, University, Guangzhou 510120, China Key Laboratory of Malignant Gene Regulation and Target Therapy Guangdong Higher Education Institutes, Engineering Ministry Education, State Biocontrol, School Life Sciences, 510275, Correspondence to: Liu, e-mail: victorlq@hotmail.com liuleopold@gmail.com Keywords: breast...
Evidence is lacking whether the number of breast tumor-initiating cells (BT-ICs) directly correlates with sensitivity tumors to chemotherapy. Here, we evaluated association between proportion BT-ICs and chemoresistance tumors.Immunohistochemical staining(IHC) was used examine expression aldehyde dehydrogenase 1 (ALDH1) proliferating cell nuclear antigen, TUNEL detect apoptosis index. The significance various variables in patient survival analyzed using a Cox proportional hazards model....
// Kai Chen 1, 2, 3, * , Jieqiong Liu Liling Zhu 2 Fengxi Su Erwei Song Lisa K. Jacobs 3 1 Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, University, Guangzhou, China Breast Center, Departments Surgery Oncology, Johns Hopkins Medical Institutions, Baltimore, MD, USA These authors have contributed equally to this work Correspondence to: Jacobs, e-mail: ljacob14@jhmi.edu Chen, chenkai23@mail.sysu.edu.cn Keywords: breast...
Abstract Myofibroblast differentiation plays an important role in the malignant progression of phyllodes tumor, a fast-growing neoplasm derived from periductal stromal cells breast. Macrophages are frequently found close proximity with myofibroblasts, but it is uncertain whether they involved myofibroblast during tumor progression. Here we show that increased density tumor-associated macrophage (TAM) correlates tumor. We TAMs stimulated and promoted proliferation invasion cells. Furthermore,...
// Xiaorong Lin 2,4,* , Lijun Chen 3,* Yandang Yao 1,2,* Ruihua Zhao 2,6,* Xiuying Cui 1,2 Jun 5 Kailian Hou 3 Mingxia Zhang Fengxi Su Jingqi and Erwei Song 1 Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics Gene Regulation, Sun Yat-Sen Memorial Hospital, University, Guangzhou, People's Republic China 2 Breast Center, SunYat-Sen Department Medical Oncology, No. Affiliated Guangzhou 4 Diagnosis Treatment Center Diseases, Shantou Shantou, Province, Tumor, The Third Hospital...
Expression of membrane-bound Fas ligand (mFasL) on colon cancer cells serves as a potential mechanism to inhibit host immune function by inducing apoptosis lymphocytes. Membrane-bound FasL can be cleaved and released soluble mediator (sFasL), which may spread the induction effect. Our study examined whether adenocarcinoma release sFasL, induce lymphocytes without direct cell-cell contact. In 12 consecutive patients with mFasL was identified in tumours, sFasL measured sera tumour-infiltrating...