A5102004490- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- RNA Research and Splicing
- Circular RNAs in diseases
- Autophagy in Disease and Therapy
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Muscle Physiology and Disorders
- Dialysis and Renal Disease Management
- Nutrition and Health in Aging
- Muscle metabolism and nutrition
- RNA and protein synthesis mechanisms
- MRI in cancer diagnosis
- Histone Deacetylase Inhibitors Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Acute Myeloid Leukemia Research
- Ferroptosis and cancer prognosis
- Cancer-related Molecular Pathways
- Cancer Immunotherapy and Biomarkers
- Cancer, Hypoxia, and Metabolism
- Ubiquitin and proteasome pathways
- Gut microbiota and health
- Cardiovascular Disease and Adiposity
- Signaling Pathways in Disease
Zhujiang Hospital
2016-2024
Southern Medical University
2003-2024
Shanghai Institute for Science of Science
2024
Shanghai University of Traditional Chinese Medicine
2024
Cell Technology (China)
2024
Nanfang Hospital
2003-2023
The First People’s Hospital of Lianyungang
2014-2022
China Medical University
2022
Southern Medical University Shenzhen Hospital
2018-2020
Shanghai First People's Hospital
2020
Oxidative stress contributes to muscle wasting in advanced chronic kidney disease (CKD) patients. Atractylenolide III (ATL-III), the major active constituent of Atractylodes rhizome, has been previously reported function as an antioxidant. This study is aimed at investigating whether ATL-III protective effects against CKD-induced by alleviating oxidative stress. The results showed that levels serum creatinine (SCr), blood urea nitrogen (BUN), and urinary protein significantly decreased...
Cervical cancer (CC) is one of the most common cancers among females worldwide. Spindle and kinetochore-associated complex subunit 3 (SKA3), located on chromosome 13q, was identified as a novel gene involved in promoting malignant transformation cancers. However, function underlying mechanisms SKA3 CC remain unknown. Using Oncomine database, we found that expression mRNA higher tissues than normal linked with poor prognosis. In our study, immunohistochemistry showed increased tissues. The...
Abstract Muscle atrophy is a common complication in chronic kidney disease (CKD). Inflammation and myostatin play important roles CKD muscle atrophy. Formononetin (FMN), which major bioactive isoflavone compound Astragalus membranaceus , exerts anti‐inflammatory effects the promotion of myogenic differentiation. Our study based on to explore mechanisms FMN relation In this study, rats tumour necrosis factor α (TNF‐α)‐induced C2C12 myotubes were used for vivo vitro models The results showed...
Abstract Skeletal muscle atrophy is a common and serious complication of chronic kidney disease (CKD). Oxidative stress autophagy are the primary molecular mechanisms involved in atrophy. Calycosin, major component Radix astragali , exerts anti‐inflammatory, anti‐oxidative anti‐autophagy effects. We investigated effects calycosin on skeletal vivo vitro. 5/6 nephrectomy (5/6 Nx) rats were used as model CKD. evaluated bodyweight levels serum creatinine (SCr), blood urea nitrogen (BUN) albumin...
Abstract B-cell acute lymphoblastic leukemia (B-ALL) is an aggressive hematological disorder with a dismal prognosis. The dysregulation of histone acetylation great significance in the pathogenesis and progression B-ALL. Regarded as fundamental acetyltransferase gene, role HBO1 (lysine 7/KAT7) B-ALL has not been investigated. Herein, we found that expression was elevated human cells associated poor disease-free survival. Strikingly, knockdown inhibited viability, proliferation, G1-S cycle...
Hypertrophy is a major predictor of progressive heart disease and has an adverse prognosis. MicroRNAs (miRNAs) that accumulate during the course cardiac hypertrophy may participate in process. However, nature any interaction between hypertrophy-specific signaling pathway aberrant expression miRNAs remains unclear. In this study, Spague Dawley male rats were treated with transverse aortic constriction (TAC) surgery to mimic pathological hypertrophy. Hearts isolated from TAC sham operated (n=5...
Skeletal muscle atrophy is a common and serious complication of chronic kidney disease (CKD). Oxidative stress mitochondrial dysfunction are involved in the pathogenesis atrophy. The aim this study was to explore effects mechanisms paeoniflorin on CKD skeletal We demonstrated that significantly improved renal function, calcium/phosphorus disorders, nutrition index 5/6 nephrectomized model rats. Paeoniflorin ameliorated expression proteins associated with differentiation, including F-box...
Abstract Chronic kidney disease (CKD) affects approximately 10% of the global population. Muscle atrophy occurs in patients with almost all types CKD, and gut microbiome is closely related to protein consumption during chronic renal failure (CRF). This study investigated effects Bacteroides plebeius on energy rats our results suggest that may combat muscle through Mystn/ActRIIB/SMAD2 pathway. A total 5/6 Nx were used as a model wasting CKD. The administered (2 × 10 8 cfu/0.2 ml) for weeks....
In recent years, microRNAs (miRNAs/miRs) have gained increasing interest in cancer research. Increasing evidences demonstrated that miRNAs are important for tumor early detection and prognosis. The present study aimed to explore the function of miR‑25 non‑small‑cell lung (NSCLC) its underlying mechanisms. expression levels Krüppel-like factor 4 (KLF4) were assessed 31 pairs tissue from patients with NSCLC. addition, biological roles NSCLC analyzed via a cell wound healing assay, Transwell...
Chronic kidney disease (CKD) affects approximately 10% of the global population. The abundance Akkermansia muciniphila (AKK) is significantly reduced in CKD patients.This study investigated effects AKK bacteria on damage and renal interstitium rats with CKD.CKD model 5/6 nephrectomy were used. supplemented (2 × 108 cfu/0.2 mL) for 8 weeks.AKK administration suppressed epithelial-mesenchymal transition (EMT), high-throughput 16S rRNA pyrosequencing showed that supplementation restored...
ObjectiveShenshuai Yingyang Jiaonang (SSYYJN), a traditional Chinese medicine formula, can ameliorate muscle atrophy associated with chronic kidney disease (CKD). However, its mechanisms of action remain unclear. This study is to investigate the molecular involved in effects SSYYJN ameliorating CKD rats. Methods: The chemical compounds were identified by UPLC-Q-Orbitrap HRMS. Considering dose-response relationship compounds, male SD rats randomly divided into Sham, Model, SSYYJN, and α-Keto...
Colorectal cancer stem cells (CSCs), characterized by self-renewal ability and high expression of proliferative genes, contribute to the chemoresistance colorectal (CRC). We aimed identify molecular mechanisms underlying CRC through comprehensive bioinformatics screenings experimental confirmation gene functions. found that FGF1 intracellular binding protein (FIBP) was correlated with poor prognosis in patients. Therefore, chemoresistant cell line HCT116-CSC markers CD44 CD133 established...
RNA polymerase I subunit D (POLR1D), which is involved in synthesis of ribosomal precursors and small RNAs, has been shown to be overexpressed several human cancer types. Nevertheless, the role POLR1D progression colorectal (CRC) remains unknown. The following study aimed investigate underlying mechanism CRC progression. In this report, we found that was significantly up‐regulated through data mining oncomine database. Furthermore, immunohistochemistry (IHC) staining a tissue microarray...
Abstract JOURNAL/nrgr/04.03/01300535-202407000-00038/figure1/v/2023-11-20T171125Z/r/image-tiff Runx2 is a major regulator of osteoblast differentiation and function; however, the role in peripheral nerve repair unclear. Here, we analyzed expression following injury found that it was specifically up-regulated Schwann cells. Furthermore, using cell-specific knockout mice, studied development regeneration multiple steps process sciatic were Runx2-dependent. Changes observed mice include...
Abstract Background Belonging to the protein arginine methyltransferase (PRMT) family, enzyme encoded by coactivator associated 1 (CARM1) catalyzes methylation of residues, especially acts on histones and other chromatin related proteins, which is essential in regulating gene expression. Beyond its well-established involvement regulation transcription, recent studies have revealed a novel role CARM1 tumorigenesis development, but there still lack systematic understanding human cancers. An...
Pulmonary artery hypertension (PAH) is a complex and progressive disease characterized by pulmonary vascular remodeling. Our previous study confirmed that NONRATT015587.2 could promote the proliferation of PASMCs However, exact mechanism which promotes PASMC unclear. Bioinformatics analysis revealed p21 located at downstream target NONRATT015587.2. expression localization were analyzed PCR fluorescence <em>in situ</em> hybridization. Proliferation was detected Cell Counting Kit‑8, flow...
Background and Purpose Liquorice is the root of Glycyrrhiza glabra , which a popular food in Europe China that has previously shown benefits for skeletal fatigue nutrient metabolism. However, mechanism active ingredients remain largely unclear. The aim this study was to investigate liquorice muscle wasting elucidate underlying mechanisms. Experimental Approach RNA‐Seq bioinformatics analysis were applied predict main target liquorice. A machine learning model docking tool used ingredients....