A5056283216- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Ferroptosis and cancer prognosis
- Ovarian cancer diagnosis and treatment
- Cancer-related molecular mechanisms research
- Antimicrobial Peptides and Activities
- Breast Cancer Treatment Studies
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Aquaculture disease management and microbiota
- Urological Disorders and Treatments
- Aquaculture Nutrition and Growth
- Lymphoma Diagnosis and Treatment
- Renal cell carcinoma treatment
- PARP inhibition in cancer therapy
- Aldose Reductase and Taurine
- Reproductive biology and impacts on aquatic species
- Cancer, Lipids, and Metabolism
- Advanced Radiotherapy Techniques
- Nanoplatforms for cancer theranostics
- 3D Printing in Biomedical Research
- Biochemical and Structural Characterization
- Advanced Nanomaterials in Catalysis
- Breast Lesions and Carcinomas
- MicroRNA in disease regulation
Guangdong Province Women and Children Hospital
2025
Xiangya Hospital Central South University
2025
Central South University
2025
First Affiliated Hospital of Guangzhou Medical University
2025
Guangzhou Medical University
2024-2025
State Key Laboratory of Food Science and Technology
2025
Jiangnan University
2025
Shenzhen Institutes of Advanced Technology
2025
Chinese University of Hong Kong
2025
Prince of Wales Hospital
2025
BackgroundOlaparib is a poly(ADP-ribose) polymerase inhibitor and cediranib an oral anti-angiogenic. In the primary analysis of this phase II study, combination cediranib/olaparib improved progression-free survival (PFS) compared with olaparib alone in relapsed platinum-sensitive ovarian cancer. This updated was conducted to characterize overall (OS) update PFS outcomes.Patients methodsNinety patients were enrolled randomized, open-label, study between October 2011 June 2013 across nine...
Abstract Long non-coding RNAs (lncRNAs) act as important regulators of tumorigenesis and development in bladder cancer. However, the underlying molecular mechanisms remain elusive. We previously identified a novel lncRNA signature related to immunity progression Here we further explored function RP11-89, discovered previous signature. Loss- gain-of experiments were performed using CCK-8 assay, flow cytometry, Transwell assays, scratch tests subcutaneous nude mouse models. High-throughput RNA...
Abstract 2H ‐arizines are important three‐membered heterocycles in organic chemistry. Recently, many advances the synthesis and functionalization of have been reported. Neber rearrangement, isomerization isoxazole, oxidation enamine, C−H bond activation, decomposition vinyl azide, alkyne, multi‐step developed for efficient assembly ‐azirines. As versatile highly strained unsaturated heterocycles, ‐azirines can be used as distinctive building blocks towards significant functional groups,...
Abstract Bladder cancer (BLCA) is one of the most common urological with increasing cases and deaths every year. In present study, we aim to construct an immune‐related prognostic lncRNA signature (IRPLS) in bladder patients explore its immunogenomic implications pan‐cancers. First, differentially expressed lncRNAs (IRDELs) were identified by ‘limma’ R package score IRPLS patient evaluated Cox regression. The dysregulation IRDELs expression between para‐cancer normal tissues was validated...
Organoids are becoming widespread in drug-screening technologies but have been used sparingly for cell therapy as current approaches producing self-organized clusters lack scalability or reproducibility size and cellular organization. We introduce a method of using hydrogels sacrificial scaffolds, which allow cells to form followed by gentle release, resulting highly reproducible multicellular structures on large scale. demonstrated this strategy endothelial mesenchymal stem self-organize...
Abstract The transglutaminase (TGase) derived from microorganisms, known for its exceptional protein cross-linking properties, holds significant application potential across various fields. In order to meet market demands such as temperature preferences, catalytic capabilities, selectivity, and the exploration of novel TGases, challenges have arisen development TGases. this study, we conducted enzymatic activity assays on TGases Shouchella clausii (strain KSM-K16) (Alkalihalobacillus...
Atherosclerosis is characterized by persistent inflammatory condition, leading to various cardiovascular complications. Foam cell formation, resulting from macrophage uptake of oxidized low-density lipoprotein (ox-LDL), contributes significantly atherosclerosis progression. This study was designed investigate the involvement bispecific phosphatase-6 (DUSP6) and its potential regulatory mechanisms in foam formation atherosclerosis. We employed THP-1 cells induce formation. The lipid droplet...
Background: Myocarditis, an autoimmune disease characterized by inflammation of the heart muscle, can lead to impaired cardiac function. Understanding cellular subpopulations within myocarditis microenvironment is crucial for improving diagnosis and treatment strategies. Methods: We first performed differential expression analysis using bulk RNA sequencing data from mouse models, identify key genes pathways. Subsequently, we integrated single-cell explore different cell through clustering...
Abstract Background There is evidence that cytological low‐grade squamous intraepithelial lesion (LSIL) associated with cervical neoplasia (CIN) in colposcopy, but its link to concurrent vaginal (VaIN) remains unclear. Methods A retrospective chart review was performed encompassed patients who were pathologically diagnosed CIN at a single center from 2017 2021. Demographics, referring cytology, HPV genotype, and histologic information recorded. The primary outcome coexisted VaIN. Results...
The cDNAs encoding antimicrobial peptides (AMPs) in the skin of Hylarana guentheri were identified, namely temporin (five peptides, termed temporin-GHa-GHd and temporin-GUa), brevinin-1 (one peptide, brevinin-1GUb), brevinin-2 (eight brevinin-2GHd-2GHj, brevinin-2GHb). Eleven 14 have novel primary structures. Synthesized GHa-GHd broad-spectrum activities against Gram-positive bacteria (Staphylococcus aureus Bacillus subtilis), Gram-negative (Escherichia coli, Vibrio alginolyticus,...
Potential environmental risks of genetically modified (GM) crops have raised concerns. To better understand the effect transgenic rice on bacterial community in paddy soil, a field experiment was carried out using pairs varieties from two subspecies (indica and japonica) containing bar transgene with herbicide resistance their parental conventional rice. The 16S rRNA gene soil genomic DNA different layers at maturity stage sequenced high-throughput sequencing Illumina MiSeq platform to...
Abstract Bladder cancer is one of the most common malignant tumors in urinary system. The development and improvement treatment efficiency require deepening understanding its molecular mechanism. This study investigated role ALPK2, which rarely studied tumors, bladder cancer. Our results showed upregulation ALPK2 cancer, data mining TCGA database association between pathological parameters patients with In vitro vivo experiments demonstrated that knockdown could inhibit through regulating...
The current study was conducted to evaluate the effect of dietary soy isoflavones (SI) on growth performance, antioxidant status, immune response and resistance Aeromonas hydrophila in juvenile grass carp (Ctenopharyngodon idella). Six diets were formulated contain 0 (control), 10, 50, 100, 500 or 1,000 mg SI per kg feed. Each diet randomly allotted triplicate net cages, each cage stocked with 30 fish. fish fed one experimental satiation twice day for 60 days. results showed that WGR DGC...
The c-Jun NH2-terminal kinases (JNKs) are an evolutionarily conserved family of serine/threonine protein that play critical roles in the pathological process species ranging from insects to mammals. However, function JNKs bacterial-induced intestinal inflammation is still poorly understood. In this study, a novel fish JNK (CiJNK) pathway was identified, and its potential bacterial muramyl dipeptide (MDP)-induced were investigated Ctenopharyngodon idella. present CiJNK found possess dual...
Premise of the Study Understanding resource allocation to reproduction, a key factor in life history tradeoffs, has long intrigued plant ecologists. Despite recognized importance understanding movement resources among flowers following variable pollination, patterns reallocation reproductive organs have not been thoroughly addressed. In this study, we aimed empirically explore how redistribute within inflorescences response differential pollination intensities. Methods Using common herb,...