A5030036035- 3D Printing in Biomedical Research
- Microfluidic and Bio-sensing Technologies
- Biosensors and Analytical Detection
- Microfluidic and Capillary Electrophoresis Applications
- Innovative Microfluidic and Catalytic Techniques Innovation
- SARS-CoV-2 detection and testing
- Cellular Mechanics and Interactions
- Advanced biosensing and bioanalysis techniques
- Mobile Health and mHealth Applications
- Electrowetting and Microfluidic Technologies
- Advanced Biosensing Techniques and Applications
- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Wound Healing and Treatments
- Molecular Junctions and Nanostructures
- Nanofabrication and Lithography Techniques
- Heart Rate Variability and Autonomic Control
- Advanced Sensor and Energy Harvesting Materials
- Micro and Nano Robotics
- Biomedical and Engineering Education
- HIV/AIDS Research and Interventions
- Advancements in Transdermal Drug Delivery
- RNA and protein synthesis mechanisms
- Non-Invasive Vital Sign Monitoring
- HIV Research and Treatment
Columbia University
2016-2025
New York Proton Center
2019
Faculty of 1000 (United States)
2016
Harlem United
2015
California Institute of Technology
2011
AIDS United
2009
Harvard University
2001-2005
University of Chicago
2004
Massachusetts Institute of Technology
2001-2003
Howard Hughes Medical Institute
2001-2003
A smartphone accessory can perform a point-of-care test that simultaneously detects three infectious disease markers from fingerprick whole blood in 15 min, as operated by health care workers trained on software app.
Vascularization of engineered human skin constructs is crucial for recapitulation systemic drug delivery and their long-term survival, functionality, viable engraftment. In this study, the latest microfabrication techniques are used a novel bioengineering approach established to micropattern spatially controlled perfusable vascular networks in 3D equivalents using both primary induced pluripotent stem cell (iPSC)-derived endothelial cells. Using printing technology makes it possible control...
An integrated approach for detecting proteins that is low-cost, portable, battery-operated, and works under field conditions such as direct sunlight has been developed. The "POCKET immunoassay" uses commercially available components, exhibits an analytical performance approaching of established bench-top techniques. It may be appropriate the diagnosis infectious diseases, HIV/AIDS, in developing countries (see picture).
The regulation of cardiac muscle contraction must differ from that skeletal muscles to effect different physiological and contractile properties. Cardiac troponin C (TnC), the key regulator contraction, possesses functional Ca<sup>2+</sup>-binding properties compared with TnC features a site I, which is naturally inactive. structure in Ca<sup>2+</sup>-saturated state has been determined by nuclear magnetic resonance spectroscopy. regulatory domain exists "closed" conformation even...
Peptides corresponding to the C-terminal heptad repeat of HIV-1 gp41 (C-peptides) are potent inhibitors entry into cells. Their mechanism inhibition involves binding in a helical conformation central coiled coil dominant-negative manner. Short C-peptides, however, have low affinity for and poor inhibitory activity, which creates an obstacle development small drug-like C-peptides. To improve potency short C-peptides that target hydrophobic pocket region gp41, we use two strategies stabilize...
This paper describes torque-actuated valves for controlling the flow of fluids in microfluidic channels. The consist small machine screws (≥500 μm) embedded a layer polyurethane cast above channels fabricated poly(dimethylsiloxane) (PDMS). is cured photochemically with place; on curing, it bonds to surrounding PDMS and forms stiff that retains an impression threads screws. were separated from ceiling by integrated into using simple procedure compatible soft lithography rapid prototyping....
This article describes fabrication of a two-component extracellular matrix (ECM) in which one component acts as stable structural element and another gels or dissolves reversibly (a modulatory component). Using composite collagen-alginate ECM, reversible crosslinking the alginate (the component) via application calcium citrate modulates cell mobility 3D collagen
Implantable microdevices often have static components rather than moving parts, and exhibit limited biocompatibility. This paper demonstrates a fast manufacturing method which can produce features in biocompatible materials down to tens of microns scale, with intricate composite patterns each layer. By exploiting unique mechanical properties hydrogels, we developed "locking mechanism" for precise actuation movement freely provide functions such as valves, manifolds, rotors, pumps, delivery...
Diabetic foot ulcers are chronic wounds that affect millions and increase the risk of amputation mortality, highlighting critical need for their early detection. Recent demonstrations wearable sensors enable real-time wound assessment, but they rely on bulky electronics, making them difficult to interface with wounds. Herein, a miniaturized, wireless, battery-free monitor measures lactate in seamlessly integrates bandages conformal attachment bed is introduced. Lactate selected due its...
Chronic wounds affect ~2% of the U.S. population and increase risks amputation mortality. Unfortunately, treatments for such are often expensive, complex, only moderately effective. Electrotherapy represents a cost-effective treatment; however, its reliance on bulky equipment limits clinical use. Here, we introduce water-powered, electronics-free dressings (WPEDs) that offer unique solution to this issue. The WPED performs even under harsh conditions-situations wherein many present fail. It...
While calcium binding to troponin C (TnC) triggers the contraction of both skeletal and cardiac muscle, there is clear evidence that different mechanisms may be involved. For example, activation heart myofilaments occurs with a single regulatory site on TnC, whereas fast two sites. The physiological difference between not understood at molecular level due lack structural details for response TnC calcium. We determined solution structures apo calcium-saturated domain human by using...
An important problem in the life sciences and health care is simple rapid detection of biomarkers. Although microfluidic devices are potentially useful addressing this problem, current techniques for automating fluid deliverywhich include valves electroosmosisrequire sophisticated microfabrication chip, bulky instrumentation, or both. In paper, we describe a reliable technique storing delivering sequence reagents to device. The low-cost, requires minimal user intervention, can be performed...
This work describes a method for patterning gold substrate with multiple, aligned self-assembled monolayers (SAMs) using light at different wavelengths. It the synthesis and characterization of an alkanethiolate SAM that is photosensitive to both 220 365 nm. A photomask acts as area-selective filter nm, single set exposures these two wavelengths through one photomask, without steps alignment between exposures, can produce three SAMs on substrate. We demonstrate versatility this...
This paper demonstrates a methodology for micromixing that is sufficiently simple it can be used in portable microfluidic devices. It illustrates the use of micromixer by incorporating into an elementary, system includes sample introduction, filtration, and valving. has following characteristics: (i) powered with single hand-operated source vacuum, (ii) allows samples to loaded easily depositing them prefabricated wells, (iii) are filtered situ prevent clogging microchannels, (iv) structure...