A5019435608- 3D Printing in Biomedical Research
- Microfluidic and Capillary Electrophoresis Applications
- Microfluidic and Bio-sensing Technologies
- Cellular Mechanics and Interactions
- Tissue Engineering and Regenerative Medicine
- Cancer Cells and Metastasis
- Extracellular vesicles in disease
- Innovative Microfluidic and Catalytic Techniques Innovation
- Advanced Biosensing Techniques and Applications
- Virus-based gene therapy research
- Sesame and Sesamin Research
- Cardiac Fibrosis and Remodeling
- Neuroblastoma Research and Treatments
- Additive Manufacturing and 3D Printing Technologies
- Electrowetting and Microfluidic Technologies
- Cell Image Analysis Techniques
- SARS-CoV-2 detection and testing
- Cardiovascular Effects of Exercise
- Pharmacology and Obesity Treatment
- Supply Chain and Inventory Management
- Myofascial pain diagnosis and treatment
- MicroRNA in disease regulation
- Natural Antidiabetic Agents Studies
- Electrospun Nanofibers in Biomedical Applications
- Slime Mold and Myxomycetes Research
Bu-Ali Sina University
2022
Columbia University
2008-2017
University of Tehran
2008
There is a growing interest in the pivotal role of exosomes cancer and their use as biomarkers.However, despite importance microenvironment for initiation progression, monolayer cultures tumor cells still represent main vitro source exosomes.As result, environmental regulation remains largely unknown.Here, we report three-dimensional model studying exosomes, using Ewing's sarcoma type 1 clinically relevant example.The bioengineered was designed based on hypothesis that 3-dimensionality,...
Cellular communities in living tissues act concert to establish intricate microenvironments, with complexity difficult recapitulate vitro. We report a method for docking numerous cellularized hydrogel shapes (100–1,000 µm size) into templates construct 3D cellular microenvironments. Each shape can be uniquely designed contain customizable concentrations of cells and molecular species, placed any spatial configuration, providing extensive compositional geometric tunability shape-coded...
We describe a microfluidic system that can control, in real time, the microenvironments of mammalian cells naturally derived 3D extracellular matrix (ECM). This chip combines pneumatically actuated valves with an individually addressable array cell-laden ECM; actuation determines pathways for delivering reagents through and exchanging diffusible factors between cell chambers. To promote rapid perfusion gels (with complete exchange within gel seconds), we created conduits above fluid flow,...
Despite the prevalence of microfluidic-based heterogeneous immunoassays (where analytes in solution are captured on a solid surface functionalized with capture molecule), there is incomplete understanding how assay parameters influence amount analytes. This study presents computational results and corresponding experimental binding assays which studied under variations both mass transfer binding, constrained by real-world conditions finite sample volume, time, area. Our identify: 1)...
Study Design Controlled laboratory study, case-control design. Objective To evaluate spine kinematics and gait characteristics in people with nonspecific chronic neck pain. Background People pain present a number of sensorimotor biomechanical alterations, yet little is known about the influence on motions during gait. Methods age- sex-matched asymptomatic controls walked treadmill at 3 different speeds (self-selected, km/h, 5 km/h), either their head neutral position or rotated 30°....
Current<italic>in vitro</italic>models fall short in deciphering the mechanisms of cardiac hypertrophy induced by volume overload.
Although individual cells vary in behavior during the formation of tissues, nature such variations are largely uncharacterized. Here, we tracked morphologies and motilities ~300 human endothelial from an initial dispersed state to capillary-like structures, distilling dynamics tissue morphogenesis into array ~36,000 numerical phenotypes. Quantitative analysis population averages revealed two previously unidentified phases which spread before forming connections with neighboring where...
Neuroblastoma is a vascularized pediatric tumor derived from neural crest stem cells that displays vasculogenic mimicry and can express number of stemness markers, such as SOX2 NANOG.Tumor relapse the major cause succumbing to this disease, properties attributed cancer stem-like (CSLC), drug-resistance cell plasticity, seem be key mechanisms.However, lack controllable models recapitulate features human neuroblastoma limits our understanding process impedes development new therapies.In...
This paper presents a distribution network design problem in multi-product supply chain system that involves locating production plants and warehouses as well determining the best strategy for distributing product from to customers. The goal is select optimum numbers, locations capacities of open, so all customer demands types are satisfied at minimum total costs network. Unlike most previous researches, our study considers system. We develop mixed-integer mathematical programming model...
Despite the prevalence of microfluidic-based heterogeneous immunoassays, there is incomplete understanding analyte capture parameters. This study presents computational results and corresponding experimental binding assays capture. Our identify: 1) a ¿reagent-limited¿ regime, under constraints finite sample volume assay time; 2) critical flow rate; 3) an increase in signal by using short concentrated plug rather than long dilute plug; 4) requirement to eventually reach reaction-limited...
هدف: تحقیق حاضر بهمنظور بررسی تأثیر مکمل کراتین بهتنهایی یا در حالت ترکیب با ورزش شنا بر مقاومت انسولینی، تحمل گلوکز و کارایی انسولین موشهای صحرایی نر چاق انجام گرفت.روشها: 50 سر موش نژاد ویستار (15±160 گرم)، بهصورت تصادفی پنج گروه قرار گرفتند: کنترل، غذای پرچرب، کراتین، تمرین همراه شنا. برنامة شامل مدت دوازده هفته بود که هر دو یکبار زمان بیشتر میشد. انتها تحت آزمون خوراکی (OGTT) گرفتند نمونههای خونی برای سنجش مقادیر TG, HDL گرفته شد. همچنین عضلة نعلی طرف راست میزان پروتئین PGC-1α...