A5032101070- Electrospun Nanofibers in Biomedical Applications
- Bone Tissue Engineering Materials
- Tissue Engineering and Regenerative Medicine
- biodegradable polymer synthesis and properties
- Advanced Sensor and Energy Harvesting Materials
- Mesenchymal stem cell research
- 3D Printing in Biomedical Research
- Graphene and Nanomaterials Applications
- Additive Manufacturing and 3D Printing Technologies
- Wound Healing and Treatments
- Angiogenesis and VEGF in Cancer
- Orthopaedic implants and arthroplasty
- Pluripotent Stem Cells Research
- Cardiac and Coronary Surgery Techniques
- Diabetic Foot Ulcer Assessment and Management
- Polymer Surface Interaction Studies
- Coronary Interventions and Diagnostics
- Conducting polymers and applications
- Periodontal Regeneration and Treatments
- Aortic aneurysm repair treatments
- Infectious Aortic and Vascular Conditions
- Polymer composites and self-healing
- RNA Interference and Gene Delivery
- Pancreatic function and diabetes
- Cellular Mechanics and Interactions
Northwestern University
2016-2025
McCormick (United States)
2011-2024
Evanston Hospital
2019-2024
California Institute for Regenerative Medicine
2021-2022
Northwestern Medicine
2021
University of Chicago Medical Center
2019
Molecular Oncology (United States)
2019
The Affiliated Yongchuan Hospital of Chongqing Medical University
2019
Chongqing Medical University
2019
Rosalind Franklin University of Medicine and Science
2019
Background/Aims: Mesenchymal stem cells (MSCs) are multipotent progenitors that can differentiate into several lineages including bone. Successful bone formation requires osteogenesis and angiogenesis coupling of MSCs. Here, we investigate if simultaneous activation BMP9 Notch signaling yields effective osteogenesis-angiogenesis in Methods: Recently-characterized immortalized mouse adipose-derived (iMADs) were used as MSC source. Transgenes BMP9, NICD dnNotch1 expressed by adenoviral...
Advances in three-dimensional (3D) printing have increased feasibility towards the synthesis of living tissues. Known as 3D bioprinting, this technology involves precise layering cells, biologic scaffolds, and growth factors with goal creating bioidentical tissue for a variety uses. Early successes demonstrated distinct advantages over conventional engineering strategies. Not surprisingly, there are current challenges to address before bioprinting becomes clinically relevant. Here we provide...
The synthesis and characterization of novel biodegradable elastomers , exemplified by poly(1,8‐octanediol‐ co ‐citric acid), is reported. Biodegradation, mechanical, biocompatibility data suggest very good potential for use as porous scaffolds in cardiovascular tissue engineering (see Figure). Material properties can be tailored modulating the monomer ratio post‐polymerization conditions.
Chronic non-healing wounds remain a major clinical challenge that would benefit from the development of advanced, regenerative dressings promote wound closure within clinically relevant time frame. The use copper ions has shown promise in healing applications possibly by promoting angiogenesis. However, reported treatments require multiple salts or oxides to bed, exposing patient potentially toxic levels and resulting variable outcomes. Herein we set out assess whether metal organic...
The successful treatment of chronic nonhealing wounds requires strategies that promote angiogenesis, collagen deposition, and re-epithelialization the wound. Copper ions have been reported to stimulate angiogenesis; however, several applications copper salts or oxides wound bed are required, leading variable outcomes raising toxicity concerns. We hypothesized copper-based metal–organic framework nanoparticles (Cu-MOF NPs), referred as HKUST-1, which rapidly degraded in protein solutions, can...
Transient electronics represents an emerging class of technology that exploits materials and/or device constructs are capable physically disappearing or disintegrating in a controlled manner at programmed rates times. Inorganic semiconductor nanomaterials such as silicon nanomembranes/nanoribbons provide attractive choices for active elements transistors, diodes and other essential components overall systems dissolve completely by hydrolysis biofluids groundwater. We describe here materials,...
Abstract Bioresorbable electronic stimulators are of rapidly growing interest as unusual therapeutic platforms, i.e., bioelectronic medicines, for treating disease states, accelerating wound healing processes and eliminating infections. Here, we present advanced materials that support operation in these systems over clinically relevant timeframes, ultimately bioresorbing harmlessly to benign products without residues, eliminate the need surgical extraction. Our findings overcome key...
3D-printed stents are fabricated with high speed and resolution by micro-continuous liquid interface production (microCLIP) of a bioresorbable, antioxidant, photopolymerizable polydiolcitrate biomaterial. Printed can match the mechanical properties bare metal strengthen porcine arteries after deployment. This technology is big step forward toward on-the-spot on-demand printing patient-specific stents. As service to our authors readers, this journal provides supporting information supplied...
Chronic wounds, particularly those associated with diabetes mellitus, represent a growing threat to public health, additional notable economic impacts. Inflammation these wounds leads abnormalities in endogenous electrical signals that impede the migration of keratinocytes needed support healing process. This observation motivates treatment chronic stimulation therapy, but practical engineering challenges, difficulties removing hardware from wound site, and absence means monitor process...
Abstract When elastomers were first proposed as useful materials for regenerative medicine a few decades ago, their high versatility and suitability diverse wide range of in vivo applications could not have been predicted. Due to ability recover after deformation, these introduced tissue engineering an attempt mimic the mechanical properties extracellular matrix. Furthermore, elastomeric characteristics described important criteria cell interaction by modulating cellular behavior. From soft...
A better understanding of protein aggregation is bound to translate into critical advances in several areas, including the treatment misfolded disorders and development self-assembling biomaterials for novel commercial applications. Because its ubiquity clinical potential, albumin one best-characterized models research; but properties different conditions are not completely understood. Here, we carried out all-atom molecular dynamics simulations understand how electrostatics can affect...
Abstract Since the discovery of nitric oxide (NO) in 1980s, this cellular messenger has been shown to participate diverse biological processes such as cardiovascular homeostasis, immune response, wound healing, bone metabolism, and neurotransmission. Its beneficial effects have prompted increased research past two decades, with a focus on development materials that can locally release NO. However, significant limitations arise when applying these biomedical applications. This Feature Article...
Current reconstructive approaches to large craniofacial skeletal defects are often complicated and challenging. Critical-sized unable heal via natural regenerative processes require surgical intervention, traditionally involving autologous bone (mainly in the form of nonvascularized grafts) or alloplasts. Autologous grafts remain gold standard care spite associated risk donor site morbidity. Tissue engineering represent a promising alternative that would serve facilitate regeneration even...
Advances in biomaterials science and engineering are crucial to translating regenerative engineering, an emerging field that aims recreate complex tissues, into clinical practice. In this regard, citrate-based have become important tool owing their versatile material biological characteristics including unique antioxidant, antimicrobial, adhesive, fluorescent properties. This review discusses fundamental design considerations, strategies incorporate functionality, examples of how can be...
Oxidative stress in tissue can contribute to chronic inflammation that impairs wound healing and the efficacy of cell-based therapies medical devices. We describe synthesis characterization a biodegradable, thermoresponsive gel with intrinsic antioxidant properties suitable for delivery therapeutics. Citric acid, poly(ethylene glycol) (PEG), poly-N-isopropylacrylamide (PNIPAAm) were copolymerized by sequential polycondensation radical polymerization produce poly(polyethylene glycol...