A5087050668- Orthopedic Surgery and Rehabilitation
- Lung Cancer Treatments and Mutations
- Elbow and Forearm Trauma Treatment
- Shoulder Injury and Treatment
- Lung Cancer Research Studies
- Tendon Structure and Treatment
- Cancer Genomics and Diagnostics
- Colorectal Cancer Treatments and Studies
- Bone fractures and treatments
- Lymphoma Diagnosis and Treatment
- Peripheral Nerve Disorders
- Sports injuries and prevention
- Cancer Immunotherapy and Biomarkers
- Medical Malpractice and Liability Issues
- Lung Cancer Diagnosis and Treatment
- Cancer therapeutics and mechanisms
- Mesenchymal stem cell research
- Dupuytren's Contracture and Treatments
- Chronic Lymphocytic Leukemia Research
- RNA Interference and Gene Delivery
- Surgical Sutures and Adhesives
- Musculoskeletal synovial abnormalities and treatments
- Pregnancy-related medical research
- PI3K/AKT/mTOR signaling in cancer
- Pancreatic and Hepatic Oncology Research
University of Chicago
2016-2025
Stanford University
2025
University of Chicago Medical Center
2017-2024
Centrum für Integrierte Onkologie
2004-2024
University Hospital Cologne
2015-2024
University of Maryland, Baltimore
2024
Molecular Oncology (United States)
2017-2023
University of Cologne
1993-2023
SUNY Downstate Health Sciences University
2012-2023
State University of New York
2012-2023
Background/Aims: Mesenchymal stem cells (MSCs) are multipotent progenitors that can differentiate into several lineages including bone. Successful bone formation requires osteogenesis and angiogenesis coupling of MSCs. Here, we investigate if simultaneous activation BMP9 Notch signaling yields effective osteogenesis-angiogenesis in Methods: Recently-characterized immortalized mouse adipose-derived (iMADs) were used as MSC source. Transgenes BMP9, NICD dnNotch1 expressed by adenoviral...
With rapid advances in understanding molecular pathogenesis of human diseases the era genome sciences and systems biology, it is anticipated that increasing numbers therapeutic genes or targets will become available for targeted therapies. Despite numerous setbacks, efficacious gene and/or cell-based therapies still hold great promise to revolutionize clinical management diseases. It wildly recognized poor delivery limiting factor most vivo There has been a long-lasting interest using viral...
Advances in three-dimensional (3D) printing have increased feasibility towards the synthesis of living tissues. Known as 3D bioprinting, this technology involves precise layering cells, biologic scaffolds, and growth factors with goal creating bioidentical tissue for a variety uses. Early successes demonstrated distinct advantages over conventional engineering strategies. Not surprisingly, there are current challenges to address before bioprinting becomes clinically relevant. Here we provide...
Little is known about the injury rates in Major League Baseball (MLB) players, as a formal surveillance system does not exist. The goal of this study was to characterize epidemiology MLB injuries over 7-year period.Injuries would be common.Descriptive epidemiologic study.The authors analyzed disabled list data from 2002 through 2008. Injuries were for differences between seasons, well during seasons on monthly basis. categorized by major anatomic zones and then further stratified based type....
Although women account for approximately half of the medical students in United States, they represent only 13% orthopaedic surgery residents and 4% members American Academy Orthopaedic Surgeons (AAOS). Furthermore, a smaller relative percentage pursue careers than any other subspecialty. Formal investigations regarding gender discrepancy choice are lacking.(1) What reasons do surgeons cite why chose this specialty? (2) perceptions think might deter from pursuing field? (3) role does early...
This is the first trial to directly compare efficacy and safety of alectinib versus standard chemotherapy in advanced/metastatic anaplastic lymphoma kinase (ALK)-positive non-small-cell lung cancer (NSCLC) patients who have progressed on, or were intolerant to, crizotinib.ALUR (MO29750; NCT02604342) was a randomized, multicenter, open-label, phase III ALK-positive NSCLC previously treated with platinum-based doublet crizotinib. Patients randomized 2 : 1 receive 600 mg twice daily (pemetrexed...
Background: There is minimal published information regarding the epidemiology of simple elbow dislocations. The purpose this study was to report estimated incidence dislocations in United States, with use National Electronic Injury Surveillance System (NEISS) database. Methods: NEISS database includes 102 hospitals representing a random sampling all patients presenting U.S. emergency departments. queried for dislocation events. data 2002 through 2006 were used raw and weighted injury counts....
Persistent tendon pain that impairs function has inconsistent medical terms can influence choice of treatment.1 When a person is told they have tendinopathy by clinician A or tendinitis B, might feel confused be alarmed at receiving what perceive as two different diagnoses. This may lead to loss confidence in their health professional and likely adds uncertainty if were search for information about condition. Clear uniform terminology also assists inter-professional communication....
BackgroundWe analyzed whether co-occurring mutations influence the outcome of systemic therapy in ALK-rearranged non-small-cell lung cancer (NSCLC).Patients and methodsALK-rearranged stage IIIB/IV NSCLC patients were with next-generation sequencing fluorescence situ hybridization analyses on a centralized diagnostic platform. Median progression-free survival (PFS) overall (OS) determined total cohort treatment-related sub-cohorts. Cox regression carried out to exclude...
Effective bone tissue engineering can restore and skeletal functions that are impaired by traumas and/or certain medical conditions. Bone is a complex through orchestrated interactions between cells, biomechanical forces, biofactors. To identify ideal scaffold materials for effective mesenchymal stem cell (MSC)-based regeneration, here we develop characterize composite nanoparticle hydrogel combining carboxymethyl chitosan (CMCh) amorphous calcium phosphate (ACP) (designated as CMCh-ACP...
Atypical EGFR mutations occur in 10%-30% of non-small-cell lung cancer (NSCLC) patients with and their sensitivity to classical epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKI) is highly heterogeneous. Patients harboring one group uncommon, recurrent (G719X, S768I, L861Q) respond EGFR-TKI. Exon 20 insertions are mostly insensitive EGFR-TKI but display exon inhibitors. Clinical outcome data very rare point compound upon systemic treatments still sparse date.In this...
Arthroscopic Bankart repair emerged in the 1990s as a minimally invasive alternative to open repair. The optimal technique of surgical stabilization unstable glenohumeral joint remains controversial.A review American Board Orthopaedic Surgery (ABOS) data would show trend toward an increasing number arthroscopic versus procedures.Descriptive epidemiology study.A query ABOS database for all cases or from 2003 through 2008 was performed, CPT (Current Procedural Terminology) codes were...
Background The absence of any agreed-upon tendon health-related domains hampers advances in clinical tendinopathy research. This void means that researchers report a very wide range outcome measures inconsistently. As result, substantial synthesis/meta-analysis research findings is almost futile despite publishing busily. We aimed to determine options for, and then define, core for tendinopathy. Methods conducted Delphi study healthcare professionals (HCP) patients three-stage process. In...
Mesenchymal stem cells (MSCs) are multipotent progenitor that can undergo self-renewal and differentiate into multiple lineages. Osteogenic differentiation from MSCs is a well-orchestrated process regulated by signaling pathways. We previously demonstrated BMP9 one of the most potent osteogenic factors. However, molecular mechanism through which governs osteoblastic remains to be fully understood. Increasing evidence indicates noncoding RNAs (ncRNAs) may play important regulatory roles in...
There are scarce data regarding the epidemiology of metacarpal fractures within US population. The purpose this study is to report in USA using National Electronic Injury Surveillance System Database (NEISS).The NEISS database represents a national probability sample approximately 100 hospitals and its territories. was queried for during time period 2002-2006. census were used calculate incidence rate (IR) various demographic criteria.A total 4,718 identified, representing 160,790 fractures....
Background: Despite high initial response rates, most patients (pts) with SCLC relapse soon after first-line (1L) treatment (tx), limited tx options and a poor prognosis. Nivo is approved in the US for of metastatic progression platinum-based chemo ≥1 other line tx. We report results from CheckMate 331 (NCT02481830), global, open-label, phase 3 trial nivo vs pts relapsed 1L chemo. Methods: Pts (N = 569) limited- or extensive-disease recurrence/progression were randomized 1:1 to receive (n...