A5073378069- Tendon Structure and Treatment
- Polymer composites and self-healing
- Electrospun Nanofibers in Biomedical Applications
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Tissue Engineering and Regenerative Medicine
- Shoulder Injury and Treatment
- Cellular Mechanics and Interactions
- Silk-based biomaterials and applications
- Bone Tissue Engineering Materials
- Organometallic Complex Synthesis and Catalysis
- Knee injuries and reconstruction techniques
- 3D Printing in Biomedical Research
- Metal-Organic Frameworks: Synthesis and Applications
- Marine Sponges and Natural Products
- Synthetic Organic Chemistry Methods
- Sports injuries and prevention
- RNA Interference and Gene Delivery
- Carbon dioxide utilization in catalysis
- Polymer Surface Interaction Studies
- Bacteriophages and microbial interactions
- biodegradable polymer synthesis and properties
- Microwave Dielectric Ceramics Synthesis
- Covalent Organic Framework Applications
- Extracellular vesicles in disease
Sichuan University
2017-2025
State Key Laboratory of Biotherapy
2019-2024
Harbin Medical University
2024
Second Affiliated Hospital of Harbin Medical University
2024
Jinan University
2024
Jilin University
2023-2024
State Key Laboratory of Food Science and Technology
2023
ShanghaiTech University
2019-2023
Shandong Provincial QianFoShan Hospital
2023
Shandong First Medical University
2023
We report a new class of porous liquids (PLs) using internally functionalized metal-organic framework (MOF) particles as pore carriers and poly(dimethylsiloxane) bulky solvents. Using generalizable noncovalent surface-initiated controlled radical polymerization technique, series isoreticular UiO-66 were dispersed in liquid PDMS matrix with excellent homogeneity colloidal stability. Benefiting from the inherent properties PDMS, PLs exhibit low vapor pressure, high thermal stability, fluidity...
Mesenchymal stem cells (MSCs) are multipotent progenitor that can undergo self-renewal and differentiate into multiple lineages. Osteogenic differentiation from MSCs is a well-orchestrated process regulated by signaling pathways. We previously demonstrated BMP9 one of the most potent osteogenic factors. However, molecular mechanism through which governs osteoblastic remains to be fully understood. Increasing evidence indicates noncoding RNAs (ncRNAs) may play important regulatory roles in...
Novel polymerized ionic liquids with different counterions were constructed, where aggregations serve as physical cross-links providing excellent self-healing performance.
Tendon regeneration is greatly influenced by the oxidant and inflammatory microenvironment. Persistent inflammation during tendon repair can cause matrix degradation, adhesion, excessive accumulation of reactive oxygen species (ROS), while ROS affect extracellular remodeling integration. Herein, we used tannic acid (TA) to modify a decellularized slice (DTS) fabricate functional scaffold (DTS-TA) with antioxidant anti-inflammatory properties for repair. The characterizations...
Abstract The formation of functional tissue is strongly dependent on biochemical as well physical signals. A common approach in engineering the application passive scaffold systems with fixed morphology and stiffness. In this paper, we explored whether mechanically active scaffolds, exhibiting self‐sufficient shape changes under physiological conditions, can be prepared from radio‐opaque shape‐memory polymer composites (SMPCs). influence different thermomechanical treatments kinetics change...
Abstract Background and Objectives Increased rigidity of the extracellular matrix (ECM) is commonly associated with hepatocellular carcinoma (HCC). The purpose this study was to quantitate mechanical stiffness various hepatic tissues, evaluate integrin β1 expression, investigate correlation between these two factors in development HCC. Methods Twenty‐three normal specimens, 152 cases cirrhosis, 105 HCC were included study. ECM each specimen detected using atomic force microscopy calculate...
In general, the design of a scaffold should imitate certain advantageous properties native extracellular matrix (ECM) to operate as temporary ECM for cells. From this perspective, biomimetic was prepared using poly(vinyl alcohol) and carrageenan in which axially oriented pore structure can be formed through facile unidirectional freeze–thaw method. We examined feasibility scaffold, has better physicochemical than non-oriented fabricated by conventional The microenvironment could biochemical...
Various composites have been prepared to improve the mechanical properties of shape-memory polymers (SMPs) or incorporate new functionalities (e.g. magneto-sensitivity) in polymer matrices. In this paper, we systematically investigated influence programming temperature Tprog and applied strain εm as parameters creation procedure (SMCP) on an amorphous polyether urethane radio-opaque thereof. Recovery under stress-free conditions was quantified by shape recovery rate Rr switching Tsw, while...
Bone regeneration is controlled by a variety of biochemical, biomechanical, cellular, and hormonal mechanisms. In particular, physical properties the substrate such as stiffness architecture highly influence proliferation differentiation cells. The aim this work to understand scaffold cell seeding densities on formation tissue osteoblast cells within polyether urethane scaffolds containing pores different sizes. MC3T3-E1 preosteoblast were seeded scaffold, amount formed was analyzed for...
Sustained, high level transgene expression in mammalian cells is desired many cases for studying gene functions. Traditionally, stable has been accomplished by using retroviral or lentiviral vectors. However, such viral vector-mediated often at low levels and can be reduced over time due to copy numbers and/or chromatin remodeling repression. The piggyBac transposon emerged as a promising non-viral vector system efficient transfer into cells. Despite its inherent advantages systems, not...
인터넷상의 데이터가 급속하게 증가함에 따라 막대한 양의 데이터를 목적에 맞게 적절히 활용하는 빅데이터 분석이 활발하게 진행되고 있다. 최근에는 기존의 정형 데이터분석이 가진 한계점을 보완하는 방법으로 비정형 데이터 분석 분야 중 하나인 텍스트마이닝 기법에 대한 연구들이 다수 이루어지고 있으며, 특히 텍스트를 기반으로 문장의 긍정, 부정을 판별하고 분류하는 감성분석과 관련된 이러한 연구의 연장선 상에서, 본 연구는 감성분석에 사용되는 감성사전을 데이터의 특성에 적절하게 변형하여 구축하는 방법을 시도하였다. 속한 영역의 특성을 고려하지 않은 범용 사용할 경우, 해당 영역에서 쓰이는 단어 또는 감정 표현을 반영하지 못하므로 감성분석의 정확성이 떨어질 수 따라서 있어서 영역 맞춤형 감성사전의 사용 시 정확하게 반영해 분석의 정확성을 높여줄 것으로 기대할 연구에서는 영화 리뷰 대상으로 선정하였으며, 대표적 영화정보 사이트 IMDb에서 발생된 약 2년간의 영화리뷰 수집 분석하였다....
In this work, we propose a computational framework for machine learning prediction on structural and performance properties of nanoporous materials methane storage application. For our prediction, two descriptors based pore geometry barcodes were developed; one descriptor is set distances from structure to the most diverse in barcode space, second extracts uses important features barcodes. First, identify optimal condition effects training preparation method, size, models investigated. Our...
Background: Poor healing of the tendon-bone interface after rotator cuff repair is one main causes surgical failure. Previous studies demonstrated that demineralized cortical bone (DCB) could improve enthesis. Purpose: To evaluate outcomes hierarchically (hDCB) coated with stem cell–derived extracellular matrix (hDCB-ECM) in a rabbit model. Study Design: Controlled laboratory study. Methods: Tendon-derived cells (TDSCs) were isolated, cultured, and identified. Then, hDCB was prepared by...
Tendon regeneration highly relies on biomechanical and biochemical cues in the repair microenvironment. Herein, we combined decellularized bovine tendon sheet (DBTS) with extracellular matrix (ECM) from tendon-derived stem cells (TDSCs) to fabricate a biomechanically biochemically functional scaffold (tECM-DBTS), provide cell ECM-based microenvironment for regeneration. Our prior study showed that DBTS was suitable repair. In this study, biological function of tECM-DBTS examined vitro,...
Polymerized ionic liquids (PILs) represent one class of promising candidates for self-healing materials because the potential diffusion ion pairs from aggregation to another. Therefore, dynamics plays crucial role in process. However, a win–win situation both efficiency and mechanical strength is major challenge PILs even all intrinsic healable materials. To resolve this challenge, series novel imidazolium-based norbornene with fine-tuned side-chain microstructures were synthesized present...
Three norbornene derivatives containing bulky hydrocarbon groups (M1–M3) have been prepared and polymerized efficiently via ring‐opening metathesis polymerization (ROMP) using different Grubbs catalysts (G1–G3) to afford polymers in high yield. Gel permeation chromatography curves show that all the obtained exhibit unimodal distribution. Unsaturated moieties main chain of are hydrogenated based on chemistry reactive intermediate diimide (HNNH) quantitative conversion, confirmed by 1H NMR...
Synergistic hard/soft gradient distribution and dynamic ionic interactions impart high mechanical strength, toughness, stretchability tenacious self-healing ability to copolymers.
The selection of appropriate cell sources is vital for the regeneration and repair tendons using stem cell-based approaches. Human adipose-derived cells (hADSCs) have emerged as a promising therapeutic strategy tendon injuries. However, heterogeneity hADSCs can lead to inconsistent or suboptimal outcomes. In this study, we isolated identified tenomodulin (TNMD)-positive subpopulation from (TNMD