A5025999561- Peripheral Artery Disease Management
- Aortic aneurysm repair treatments
- Diabetic Foot Ulcer Assessment and Management
- Wound Healing and Treatments
- Vascular Procedures and Complications
- Cardiac, Anesthesia and Surgical Outcomes
- Venous Thromboembolism Diagnosis and Management
- Aortic Disease and Treatment Approaches
- Abdominal vascular conditions and treatments
- Diagnosis and Treatment of Venous Diseases
- Infectious Aortic and Vascular Conditions
- Renal and Vascular Pathologies
- Cerebrovascular and Carotid Artery Diseases
- Gallbladder and Bile Duct Disorders
- Cardiac Valve Diseases and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Surgical Sutures and Adhesives
- Mesenchymal stem cell research
- Hippo pathway signaling and YAP/TAZ
- Planarian Biology and Electrostimulation
- Fatty Acid Research and Health
- Prosthetics and Rehabilitation Robotics
- Vascular anomalies and interventions
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Systemic Sclerosis and Related Diseases
Massachusetts General Hospital
2019-2025
Beth Israel Deaconess Medical Center
2022-2024
Harvard University
2020-2024
Dartmouth Institute for Health Policy and Clinical Practice
2023
Yale University
2011-2022
Erasmus MC
2022
Harvard University Press
2022
Memorial Medical Center
2022
UMass Memorial Medical Center
2022
Palo Alto University
2020
Diabetic foot ulcers are chronic wounds that affect millions and increase the risk of amputation mortality, highlighting critical need for their early detection. Recent demonstrations wearable sensors enable real-time wound assessment, but they rely on bulky electronics, making them difficult to interface with wounds. Herein, a miniaturized, wireless, battery-free monitor measures lactate in seamlessly integrates bandages conformal attachment bed is introduced. Lactate selected due its...
Chronic wounds affect ~2% of the U.S. population and increase risks amputation mortality. Unfortunately, treatments for such are often expensive, complex, only moderately effective. Electrotherapy represents a cost-effective treatment; however, its reliance on bulky equipment limits clinical use. Here, we introduce water-powered, electronics-free dressings (WPEDs) that offer unique solution to this issue. The WPED performs even under harsh conditions-situations wherein many present fail. It...
A commonly used treatment for open wounds, negative pressure wound therapy (NPWT) has recently been to optimize healing in the setting of surgically closed wounds; however, specific mechanisms action by which NPWT may benefit patients after surgery remain unknown. Using a swine model, current study investigates angiogenesis as candidate mechanism.Multiple excisional wounds were created on dorsa 10 male Yorkshire pigs and primary suture. The underwent with either dressing or control dressings...
Objective: To evaluate the efficacy of layer-by-layer (LbL) formulated therapeutic RNAs that inhibit PHD2 and microRNA-210 (miR-210), to improve impaired diabetic wound healing. Approach: We employed neuroischemic rabbit model Diabetes was induced in rabbits with alloxan, neuroischemia by ligating central neurovascular bundle each ear. Four 6-mm full-thickness wounds were creating on A technique conformally coat dressings a chemically modified antisense RNA (antimiR) against miR-210 an...
Objectives: To identify proteins that are prognostic for diabetic foot ulcer (DFU) healing and may serve as biomarkers its management, serum samples were analyzed from mellitus (DM) patients. Approach: The specimens evaluated in this study obtained DM patients with DFU who participated a prospective seen biweekly until they healed their or the exit visit at 12 weeks. group was divided into Healers (who during study) Non-Healers. Results: Interleukin (IL)-10, IL-4, IL-5, IL-6, IL-13...
To determine if routine completion angiography for lower extremity bypasses using vein conduit results in rates of postoperative bypass occlusion.With the increasing availability on-table and significant advancements endovascular techniques, some operators routinely perform angiograms. The effect this surgical paradigm has yet to be rigorously compared more widespread selective use imaging modern era.This retrospective cohort study included infrainguinal arterial procedures utilizing...
Abstract Background/purpose Lack of robust, feasible, and quantitative outcomes impedes Raynaud phenomenon (RP) clinical trials in systemic sclerosis (SSc) patients. Hyperspectral imaging (HSI) non-invasively measures oxygenated deoxygenated hemoglobin (oxyHb deoxyHb) concentrations oxygen saturation (O 2 sat) the skin depicts data as oxygenation heatmaps. This study explored potential role HSI quantifying SSc-RP disease severity activity. Methods Patients with ( n = 13) healthy control...