A5083526044- Prostate Cancer Treatment and Research
- Pulmonary Hypertension Research and Treatments
- Ubiquitin and proteasome pathways
- Cancer-related molecular mechanisms research
- Beetle Biology and Toxicology Studies
- Analytical chemistry methods development
- Monoclonal and Polyclonal Antibodies Research
- Peptidase Inhibition and Analysis
- RNA modifications and cancer
- Invertebrate Immune Response Mechanisms
- Photodynamic Therapy Research Studies
- Protease and Inhibitor Mechanisms
- Cancer, Lipids, and Metabolism
- Advanced Breast Cancer Therapies
- Redox biology and oxidative stress
- Cancer Cells and Metastasis
- Organic and Molecular Conductors Research
- Biosensors and Analytical Detection
- RNA Interference and Gene Delivery
- Circular RNAs in diseases
- Organ Transplantation Techniques and Outcomes
- Nanoplatforms for cancer theranostics
- Advanced Image Processing Techniques
- Advanced Measurement and Detection Methods
- Immunotherapy and Immune Responses
The First People’s Hospital of Lianyungang
2019-2024
Xuzhou Medical College
2019-2024
Nanjing University of Information Science and Technology
2023
Umeå University
2019-2022
Shenzhen Institutes of Advanced Technology
2016
Chinese Academy of Sciences
2016
Beijing Jiaotong University
2015
Tsinghua University
2015
University Town of Shenzhen
2015
Jilin University
2015
Currently, no effective targeted therapeutics exists for treatment of metastatic prostate cancer (PCa). Given that matrix metalloproteinases 9 (MMP9) and its associated vascular endothelial growth factor (VEGF) are critical tumor vascularization invasion under castration-resistant condition, it is therefore great importance to define the functional association interplay between androgen receptor (AR) MMP9 their key survival pathways in PCa cells. Here, we found there was a significant...
Abstract Pulmonary arterial hypertension (PAH) is characterized by a progressive increase in pulmonary vascular resistance and obliterative remodelling (PVR). The imbalance between the proliferation apoptosis of artery smooth muscle cells (PASMCs) an important cause PVR leading to PAH. Mitochondria play key role production hypoxia‐induced (HPH). However, there are still many issues worth studying depth. In this study, we demonstrated that NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 4...
Sialic acid (SA) is a monosaccharide usually linked to the terminus of glycan chains on cell surface. It plays crucial role in many biological processes, and hypersialylation common feature cancer. Lectins are widely used analyze surface expression SA. However, these protein molecules expensive easily denatured, which calls for development alternative glycan-specific receptors imaging technologies. In this study, SA-imprinted fluorescent core-shell molecularly imprinted polymer particles...
Selective ERα modulator, tamoxifen, is well tolerated in a heavily pretreated castration-resistant prostate cancer (PCa) patient cohort. However, its targeted gene network and whether expression of intratumor due to androgen deprivation therapy (ADT) may play role PCa progression unknown. In this study, we examined the inhibitory effect tamoxifen on vitro vivo. We found that potent compound induced high degree apoptosis significantly suppressed growth xenograft tumors mice, at comparable...
Pulmonary artery hypertension (PAH) is a complex and progressive disease characterized by pulmonary vascular remodeling. Our previous study confirmed that NONRATT015587.2 could promote the proliferation of PASMCs However, exact mechanism which promotes PASMC unclear. Bioinformatics analysis revealed p21 located at downstream target NONRATT015587.2. expression localization were analyzed PCR fluorescence <em>in situ</em> hybridization. Proliferation was detected Cell Counting Kit‑8, flow...
PIP5K1α has emerged as a promising drug target for the treatment of castration-resistant prostate cancer (CRPC), it acts upstream PI3K/AKT signaling pathway to promote (PCa) growth, survival and invasion. However, little is known molecular actions in this process. Here, we show that siRNA-mediated knockdown blockade action using its small molecule inhibitor ISA-2011B suppress growth invasion CRPC cells. We demonstrate targeted deletion N-terminal domain cells results reduced migratory...
Sialyl-Tn (STn or sialyl-Thomsen-nouveau) is a carbohydrate antigen expressed by more than 80% of human carcinomas. We here report strategy for ratiometric STn detection and dual-color cancer cell labeling, particularly, molecularly imprinted polymers (MIPs). Imprinting was based on spectroscopic studies urea-containing green-fluorescent monomer 1 STn-Thr-Na (sodium salt Neu5Acα2-6GalNAcα-O-Thr). A few-nanometer-thin polymer shell, in which with 1, other comonomers, cross-linker, synthesized...
To date, numerous studies have suggested that microRNAs (miRNAs) and genes play key roles in osteosarcoma (OS); however, the majority of these been conducted with a specific focus on either or miRNAs, which has made regulatory mechanisms OS difficult to decipher. The aim present study was systematically investigate elements [genes, miRNAs transcription factors (TFs)] associated morbidity explore associations among elements, instead focusing one several elements. scattered data were collected...
Cancer cells facilitate growth and metastasis by using multiple signals from the cancer-associated microenvironment. However, it remains poorly understood whether prostate cancer (PCa) may recruit utilize bone marrow for their survival. Furthermore, regulatory mechanisms underlying interactions between PCa are obscure. In this study, we isolated that mainly constituted populations were positive CD11b Gr1 antigens xenograft PC-3 tumor tissues athymic nu/nu mice. We found tumor-infiltrated...
Purpose: There is an urgent need for developing new biomarker tools to accurately predict treatment response of breast cancer, especially the deadly triple-negative cancer. We aimed develop gene-mutation-based machine learning (ML) algorithms as classifiers first-line chemotherapy with high precision. Methods: Random Forest ML was applied screen various combinations gene mutation profiles primary tumors at diagnosis using a TCGA Cohort (n = 399) up 150 months follow-up training set and...
Low-affinity immunoglobulin gamma Fc region receptor III-A (FcγRIIIa) is a cell surface protein that belongs to family of receptors facilitate the protective function immune system against pathogens. However, role FcγRIIIa in prostate cancer (PCa) progression remained unknown. In this study, we found expression was present PCa cells and its level significantly higher metastatic lesions than primary tumors from cohort (P = 0.006). patients with an elevated had poorer biochemical recurrence...
Abstract Background and purposes It is unclear whether the parent Saxagliptin (SAX) in vivo same as that vitro, which twice of 5-hydroxy (5-OH SAX). This study to construct a Pharmacokinetic-Pharmacodynamic (PK-PD) link model evaluate genuine relationship between concentration SAX effect. Methods First, we established reliable Ultra Performance Liquid Chromatography-Mass Spectrometry (UPLC-MS/MS) method DPP-4 inhibition ratio determination method. Then, T2DM rats were randomly divided into...