A5100321984- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Kruppel-like factors research
- RNA modifications and cancer
- RNA Research and Splicing
- Pulmonary Hypertension Research and Treatments
- Genomics, phytochemicals, and oxidative stress
- Beetle Biology and Toxicology Studies
- Galectins and Cancer Biology
- Cancer, Lipids, and Metabolism
- Pregnancy and Medication Impact
- Molecular Biology Techniques and Applications
- Hearing, Cochlea, Tinnitus, Genetics
- Pregnancy and preeclampsia studies
- Fibroblast Growth Factor Research
- Virus-based gene therapy research
- Cancer Cells and Metastasis
- NF-κB Signaling Pathways
- Natural product bioactivities and synthesis
- Multiple Sclerosis Research Studies
- Ultrasound and Hyperthermia Applications
- Tumors and Oncological Cases
- Sulfur Compounds in Biology
- Heat shock proteins research
Guangxi Medical University
2019-2025
First Affiliated Hospital of GuangXi Medical University
2019-2025
China Three Gorges University
2023-2025
Shanghai Xuhui Central Hospital
2025
Fudan University
2022-2025
Shaanxi Provincial People's Hospital
2025
Capital Medical University
2015-2024
Jiangsu University
2018-2024
Beijing Tian Tan Hospital
2023-2024
Tianjin Medical University Cancer Institute and Hospital
2023
Increasing evidence has demonstrated a significant role of long non-coding RNAs (lncRNAs) in diverse biological processes, and many which are likely to have functional roles vascular remodeling. However, their functions pulmonary arterial hypertension (PAH) remain largely unknown. Pulmonary remodeling is an important pathological feature PAH, leading increased resistance reduced compliance. artery smooth muscle cells (PASMCs) dysfunction involved Long noncoding potential regulators PASMCs...
Childhood asthma is a heterogeneous disease that exhibits different characteristics and varying severity; however, the metabolite alterations underlying difference in severity, especially severe asthma, are not well understood. The aim of this study was to identify plasma metabolic profile children with severity explore potential intervention targets glucocorticoid resistance. Untargeted liquid chromatography mass spectrometry utilized analyze metabolites 54 mild-to-moderate 50 39 healthy...
Assembling evidences suggested that aberrant expression of tissue differentiation-inducing non-protein coding RNA (TINCR) intimately associated with variety human cancer. However, the pattern and involvement TINCR in breast cancer has not been fully investigated. Here we set out to analyze elucidate its mechanistic tumor incidence progression. The was determined by q-PCR. SP1 binding sites were analyzed ChIP-qPCR. relative transcription activity measured luciferase reporter assay. Cell...
Abstract Although cadmium (Cd)‐induced hepatoxicity is well established, pronounced knowledge gaps remain existed regarding the inherent cellular signaling that dictates Cd toxicity. Specifically, molecular basis for determining equilibrium between prosurvival and proapoptotic remains poorly understood. Thus, it recently revealed long non‐coding RNA (lncRNA) MT1DP, a pseudogene in metallothionein (MT) family, promoted Cd‐induced cell death through activating RhoC‐CCN1/2‐AKT pathway...
Gastric cancers are highly heterogeneous malignant tumors. To reveal the relationship between differentiation status of cancer cells and tumor immune microenvironments in gastric cancer, single-cell RNA-sequencing was performed on normal mucosa tissue, differentiated (DGC) poorly (PDGC) tissue neuroendocrine carcinoma (NEC) sampled from surgically resected specimens. We identified signature genes for both DGC PDGC, found that PDGC strongly enriched epithelial-mesenchymal transition (EMT)...
Background: Asthma is characterized by airway remodeling arising from an increase in smooth muscle (ASM) mass. This regulated part ASM cell proliferation and migration. MicroRNA (miR)-21 also plays a role asthma, but the molecular mechanisms underlying its effects are not completely understood. study investigated mechanism of miR-21 on human (HASM) Materials Methods: HASM cells were transduced with vector, expression was determined quantitative real-time polymerase chain reaction (qRT-PCR)....
Abstract Aim: This research aims to investigate the expression profile of circRNA in osteosarcoma and identify underlying pathogenesis core genes osteosarcoma. Methods: Illumina HiSeq was used screen differentially expressed circRNAs between tumour tissues paracancerous three patients. Bioinformatics analysis analyse their potential functions. Five were selected detect relative level ten patients by real-time PCR. The databases such as DisGeNET miRWalk collect related or miRNAs. Results: A...
Abstract Background Recently, the roles of long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) in human diseases have been unveiled, this research was conducted to explore impacts lncRNA SET-binding factor 2-antisense RNA1 (SBF2-AS1), miR-143 resistance ralstonia solanacearum 1 (RRS1) on breast cancer (BC) development. Methods The expression SBF2-AS1, RRS1 BC tissues, as well MDA-MB-231 MCF-7 cell lines were assessed. Subsequently, cells transfected with mimics or/and silenced or...
Purposes: To measure expression levels of CD47 during endometrial carcinoma development, and to determine specific modulatory effects. Methods: in tissues adjacent were analyzed using qRT-PCR. CD47-overexpressed or downregulated cell models established plasmid shRNA. The effects on HEC-1A Ishikawa growth evaluated CCK-8 assays. Migration ability transfected cells examined wound healing Flow cytometry was used the apoptosis cycle cells. Western blot analyze correlation between level...
Helicobacter pylori (H.pylori, HP) is one of the main causes gastric cancer (GC). CircRNAs have been reported to play a crucial role in developing many types cancer. However, circRNAs development and progression HP infected-GC has not studied. The location circRNA_15430 GC cells were detected by nuclear cytoplasmic RNA fractionation fluorescence situ hybridization analysis (FISH) assays, circRNA_15430, miR-382-5p ZCCHC14 expression cell lines tissues analyzed quantitative real-time...
Abstract Purpose Helicobacter pylori ( H. ) has unique biochemical traits and pathogenic mechanisms, which make it a substantial cause of gastrointestinal cancers. Circular RNAs (circRNAs) have concurrently been identified as an important participating factor in the pathophysiology several different However, underlying processes putative interactions between circRNAs received very little attention. To address this issue, we explored interaction to investigate how they might jointly...
Metallothioneins (MTs) are known to protect cells against oxidative stress, especially providing protection cadmium (Cd) toxicity in hepatocytes. There various gene variants and pseudogenes for MTs; however, there is little understanding on the functions of those non-coding MT members that be expressed as long RNAs (lncRNAs) nowadays. Different from most protein-coding members, MT1DP was here found remarkably induced provoke cytotoxicity hepatocytes response Cd treatment. exerted such a...
Background: Circular RNA is a type of non-coding with great potential in regulating gene expression and associated disease progression.However, the role circular endometrial carcinoma (EC) remains largely unknown.Results: In this study, we found that circTNFRSF21 was highly expressed EC cells tumor tissues.In vitro vivo results showed linked to increased cell growth xenografts formation nude mice.Mechanically, acts as sponge miR-1227 rescue MAPK13/ATF2 signaling pathway activity.Conclusions:...
Abstract Endometrial cancer is a common gynaecological malignant tumour among women across the world. Circular RNAs (circRNAs) are novel kind of non‐coding RNAs, and they can play crucial role in multiple cancers. Nevertheless, mechanisms circRNAs regulating gene expression endometrial still unclear. Here, our work sought to focus on that circ_0067835 exert progression development cells. We observed was markedly elevated cancer. Then, changes cell (RL95‐2 HEC‐1B) function were determined...
Accumulating evidence suggests that circular RNAs (circRNAs) are involved in immune and inflammatory processes after acute ischemic stroke (AIS). However, the roles of circRNA-mediated competing endogenous RNA (ceRNA) modulating inflammation AIS have not yet been determined. This study aimed to construct a immune-related ceRNA network identify novel circRNAs AIS.Microarray data were downloaded from GEO database further analysed by R software. Then, we constructed based on interaction...