A5072596262- Neuroinflammation and Neurodegeneration Mechanisms
- Parkinson's Disease Mechanisms and Treatments
- MicroRNA in disease regulation
- Neurological Disease Mechanisms and Treatments
- Inflammasome and immune disorders
- Acute Ischemic Stroke Management
- Neuroscience and Neuropharmacology Research
- Alzheimer's disease research and treatments
- Genetic Neurodegenerative Diseases
- Mitochondrial Function and Pathology
- Mesenchymal stem cell research
- Circular RNAs in diseases
- Immune Response and Inflammation
- Vagus Nerve Stimulation Research
- Advanced Computing and Algorithms
- Cancer-related molecular mechanisms research
- Tryptophan and brain disorders
- Cerebrovascular and Carotid Artery Diseases
- Neurological disorders and treatments
- Atrial Fibrillation Management and Outcomes
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurosurgical Procedures and Complications
- S100 Proteins and Annexins
- Nerve injury and regeneration
- Adenosine and Purinergic Signaling
Xuzhou Medical College
2016-2025
Beijing Shijitan Hospital
2024-2025
Capital Medical University
2024-2025
Union Hospital
2023
Huazhong University of Science and Technology
2023
Affiliated Hospital of Xuzhou Medical College
2008-2016
Ischemic postconditioning (IPOC), or relief of ischemia in a stuttered manner, has emerged as an innovative treatment strategy to reduce programmed cell death, attenuate ischemic injuries, and improve neurological outcomes. However, the mechanisms involved have not been completely elucidated. Recent studies indicate that autophagy is type death plays elusive roles controlling neuronal damage metabolic homeostasis. This study aims determine role IPOC-induced neuroprotection against focal...
Dendritic cell-associated C-type lectin-1 (Dectin-1) receptor has been reported to be involved in neuroinflammation Alzheimer's disease and traumatic brain injury. The present study was designed investigate the role of Dectin-1 its downstream target spleen tyrosine kinase (Syk) early injury after ischemic stroke using a focal cortex model.Adult male C57BL/6 J mice were subjected cerebral ischemia model stroke. neurological score, adhesive removal test, foot-fault test evaluated on days 1, 3,...
Abstract In rats with type 1 diabetes (T1DM), the therapeutic effects and underlying mechanisms of action stroke treatment were compared between bone-marrow stromal cells (BMSCs) derived from T1DM (DM-BMSCs) BMSCs normal (Nor-BMSCs). The novel role microRNA-145 (miR-145) in mediating DM-BMSC treatment-induced benefits was also investigated. (n = 8 per group) underwent 2 hours middle cerebral artery occlusion (MCAo) treated 24 later one following (5 × 106 administered i.v.): (a)...
Abstract Background The rapidly increasing case reports revealed that neuronal intranuclear inclusion disease (NIID) had concomitant other system symptoms besides nervous symptoms. In this study, we systematically evaluated the symptoms, signs, auxiliary examination, and pathological changes in different systems NIID patients. Methods patients were confirmed by examining GGC repeats NOTCH2NLC gene. Clinical data of including examinations collected for analysis. Ubiquitin p62 detected tissues...
Early and precise diagnosis of α-synucleinopathies is challenging but critical. In this study, we developed a molecular beacon-based assay to evaluate microRNA-containing extracellular vesicles (EVs) in plasma. We recruited 1203 participants including healthy controls (HCs) patients with isolated REM sleep behavior disorder (iRBD), α-synucleinopathies, or non-α-synucleinopathies from eight centers across China. Plasma miR-44438-containing EV levels were significantly increased those the...
Abstract Objective Microglial polarization plays a critical role in neuroinflammation and may be potential therapeutic target for ischemic stroke. This study was to explore the underlying molecular mechanism of Circular RNA PTP4A2 (circPTP4A2) microglial after Methods C57BL/6J mice underwent transient middle cerebral artery occlusion (tMCAO), while primary mouse microglia BV2 cells experienced oxygen glucose deprivation/reperfusion (OGD/R) mimic conditions. CircPTP4A2 shRNA lentivirus...
Abstract Ischemic postconditioning provides robust neuroprotection, therefore, determining the molecular events may provide promising targets for stroke treatment. Here, we showed that expression of functional mitochondrial voltage-dependent anion channel proteins (VDAC1, VDAC2, and VDAC3) reduced in rat vulnerable hippocampal CA1 subfield after global ischemia. restored VDACs to physiological levels. Stabilized contributed benefits postconditioning. VDAC1 was required maintaining neuronal...
Studies have shown that there is a relationship between smoke exposure and constipation. However, are limited data on the associations constipation smoking or serum cotinine levels, metabolite of nicotine commonly used as marker tobacco exposure. This study thoroughly examined cross-sectional from National Health Nutrition Examination Survey (NHANES) 2005 to 2010. We applied multivariate logistic regression models assess association status, In this study, 11,651 participants were included....
Myeloid differentiation primary-response protein-88 (MyD88) is one of adaptor proteins mediating Toll-like receptors (TLRs) signaling. Activation MyD88 results in the activation nuclear factor kappa B (NFκB) and increase inflammatory responses. Evidences have demonstrated that TLRs signaling contributes to cerebral ischemia/reperfusion (I/R) injury. However, role this mechanism action disputed needs be clarified. In present study, a mouse model I/R, we examined activities NFκB interferon...
This study aimed to evaluate the specific regulatory roles of microRNA-146a (miRNA-146a) in temporal lobe epilepsy (TLE) and explore related mechanisms. A rat model TLE was established by intraperitoneal injection lithium chloride-pilocarpine. These rats were injected intracerebroventricularly with an miRNA-146a inhibitor Notch-1 siRNA. Then, neuronal damage cell apoptosis cornu ammonis (CA) 1 3 regions hippocampus assessed. SOD MDA levels detected chromatometry, IL-1β, IL-6, IL-18 ELISA. we...
Accumulating evidence suggests that circular RNAs (circRNAs) are involved in immune and inflammatory processes after acute ischemic stroke (AIS). However, the roles of circRNA-mediated competing endogenous RNA (ceRNA) modulating inflammation AIS have not yet been determined. This study aimed to construct a immune-related ceRNA network identify novel circRNAs AIS.Microarray data were downloaded from GEO database further analysed by R software. Then, we constructed based on interaction...
The expansion of GGC repeats within NOTCH2NLC leads to translation the uN2CpolyG protein, primary pathogenic factor in neuronal intranuclear inclusion disease (NIID). aim this study was explore deposition as an amyloid vessel wall, leading cerebral angiopathy-related microbleeds (CMBs). A total 97 patients with genetically confirmed NIID were enrolled study. We analysed presence CMBs using susceptibility-weighted imaging sequences and compared general clinical information, cerebrovascular...