A5060670605- Cancer Immunotherapy and Biomarkers
- Radiopharmaceutical Chemistry and Applications
- Cancer, Stress, Anesthesia, and Immune Response
- Medical Imaging Techniques and Applications
- Effects of Radiation Exposure
- Cardiovascular Disease and Adiposity
- Lung Cancer Research Studies
- Mathematical and Theoretical Epidemiology and Ecology Models
- Adipose Tissue and Metabolism
- Chemotherapy-induced cardiotoxicity and mitigation
- Cancer-related molecular mechanisms research
- Pancreatitis Pathology and Treatment
- Urological Disorders and Treatments
- Immune cells in cancer
- RNA modifications and cancer
- Sexual function and dysfunction studies
- Mathematical Biology Tumor Growth
- Tissue Engineering and Regenerative Medicine
- Pediatric Hepatobiliary Diseases and Treatments
- Mathematical Analysis and Transform Methods
- Andrographolide Research and Applications
- Graph Labeling and Dimension Problems
- Graph theory and applications
- Curcumin's Biomedical Applications
- TGF-β signaling in diseases
Third Affiliated Hospital of Southern Medical University
2024
Tianjin Medical University Cancer Institute and Hospital
2013-2023
Yinchuan First People's Hospital
2023
First Affiliated Hospital of Anhui Medical University
2020
Anhui Medical University
2020
NYU Langone Health
2020
Harbin Medical University
2014
Harbin Engineering University
2014
Beihua University
2005-2011
Lanzhou University Second Hospital
2003
During obesity, macrophages infiltrate the visceral adipose tissue and promote inflammation that contributes to type II diabetes. Evidence suggests rewiring of cellular metabolism can regulate macrophage function. However, metabolic programs characterize (ATM) in obesity are poorly defined. Here, we demonstrate ATM from obese mice exhibit profiles characterized by elevated glycolysis oxidative phosphorylation, distinct lean mice. Increased activation HIF-1α resulted induction IL-1β genes...
Abstract Concurrent PD-1 blockade and thoracic radiotherapy is being investigated in clinical trials for locally advanced, non–small cell lung cancer small cancer, despite a potential overlapping risk of cardiotoxicity. Our prior studies demonstrate that cardiotoxicity from concurrent cardiac irradiation anti–PD-1 administration mouse model CD8+ T-cell dependent. The objective this study was to determine whether humoral immunity contributed the observed tissue damage, as measured by creatine...
Introduction Ferroptosis plays a significant role in intervertebral disc degeneration (IDD). Understanding the key genes regulating ferroptosis IDD could reveal fundamental mechanisms of disease, potentially leading to new diagnostic and therapeutic targets. Methods Public datasets (GSE23130 GSE70362) FerrDb database were analyzed identify ferroptosis-related (DE-FRGs) involved IDD. Single-cell RNA sequencing data (GSE199866) was used validate specific roles expression patterns these genes....
To supplement nutrition, jejunostomy has been widely adopted as an adjunct surgical procedure for Ivor-Lewis esophagectomy. Most Chinese surgeons have a preference parenteral nutrition even though it some disadvantages compared with jejunostomy. In this report, we describe new approach that allows the quick insertion of feeding tube in We retrospectively analyze cases applied and compare advantages jejunostomy.Between January 2010 December 2012, 131 patients underwent esophagectomy our...
The five-year survival rate of lung squamous cell carcinoma is significantly lower than that other cancer types. It therefore urgent to discover novel prognosis biomarkers and therapeutic targets understand their correction with infiltrating immune cells improve the patients carcinoma. In this study, we employed robust rank aggregation algorithms overcome shortcomings small sizes potential bias in each Gene Expression Omnibus dataset identified 513 differentially expressed genes including...
Objective: To study and analyze the effect of endovascular angioplasty in lower extremity arteriosclerosis obliterans.Methods: 60 patients with obliterans admitted to our hospital from January 2021 July were selected divided into group control 30 cases each by random number table method.Both groups treated angioplasty, was percutaneous balloon drug-coated angioplasty.Follow-up conducted for 12 months after treatment, therapeutic prognostic effects two evaluated compared at last follow-up....
A time domain identification method for distributed dynamic loads on 1D spatial structures was proposed. Based the idea of and temporal divisions, formula process load history were derived. The program compiled by means MATLAB, verified through 2 examples: a simply supported beam subjected to power line stochastic wind loads. Moreover, effect noise investigated numerical simulation. It is shown that can be accurately identified linear problems approximately weakly nonlinear with presented...
During obesity, macrophages (Mø) accumulate in the visceral adipose tissue (VAT), giving rise to a state of chronic, low-grade inflammation that promotes insulin resistance and type 2 diabetes. We hypothesized activation HIF-1α highly-metabolically active Mø sustains obese VAT metabolic dysfunction. show hypoxic Mø, like M1-polarized shift their metabolism from oxidative phosphorylation glycolysis, leading accumulation HIF-1α-stabilizing intermediates. Extracellular flux analysis showed...
Abstract Background : Concomitant boost irradiation (CB) in adjuvant whole breast radiotherapy (WBI) is increasingly prevalent. Multiple studies have reported the effect of CB; however, long-term outcomes after CB remain unknown. Methods Totally 266 patients administered breast-conserving surgery from March 2007 to November 2012 were included this retrospective analysis. They WBI at 45 Gy (range, 43.2-46) 23 fractions 18-25). was delivered shortly completion with 9 or 12 Mevβ electrons a...
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<div>Abstract<p>Concurrent PD-1 blockade and thoracic radiotherapy is being investigated in clinical trials for locally advanced, non–small cell lung cancer small cancer, despite a potential overlapping risk of cardiotoxicity. Our prior studies demonstrate that cardiotoxicity from concurrent cardiac irradiation anti–PD-1 administration mouse model CD8<sup>+</sup> T-cell dependent. The objective this study was to determine whether humoral immunity contributed the...