A5069233763- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Musculoskeletal pain and rehabilitation
- Scoliosis diagnosis and treatment
- Pelvic and Acetabular Injuries
- Medical Imaging and Analysis
- Osteoarthritis Treatment and Mechanisms
- Orthopaedic implants and arthroplasty
- Pain Mechanisms and Treatments
- Pregnancy-related medical research
- Circular RNAs in diseases
- Spinal Hematomas and Complications
- Shoulder Injury and Treatment
- Bone Metabolism and Diseases
- Management of metastatic bone disease
- Hepatitis B Virus Studies
- Inflammatory mediators and NSAID effects
- Cervical and Thoracic Myelopathy
- Plant Toxicity and Pharmacological Properties
- Healthcare and Venom Research
- Liver Disease Diagnosis and Treatment
- Anesthesia and Pain Management
- Cancer-related molecular mechanisms research
- Intraoperative Neuromonitoring and Anesthetic Effects
- Aortic Disease and Treatment Approaches
Sun Yat-sen University
2016-2025
The First Affiliated Hospital, Sun Yat-sen University
2016-2025
University of Pennsylvania
2018-2024
Fifth Affiliated Hospital of Sun Yat-sen University
2024
Tokai University
2018-2023
Key Laboratory of Guangdong Province
2021-2023
AO Foundation
2018-2023
Shandong Provincial QianFoShan Hospital
2019-2023
Shandong First Medical University
2023
Martin University
2019
Elevated levels of TNF-α, IL-1β and a resultant increase in ADAMTS (a disintegrin-like metalloprotease with thrombospondin type I motifs) expression is seen during disc degeneration. However, if these pro-inflammatory cytokines control activity not definitively known. The goal the investigation was to study TNF-α regulate syndecan-4 (SDC4) expression, SDC4 responsible for promoting aggrecan degradation through controlling nucleus pulposus cells intervertebral disc. Cytokine treatment...
Abstract The inflammatory response is induced by the overexpression of cytokines, mainly interleukin (IL)-1β, and one main causes intervertebral disc degeneration (IVDD). NLR pyrin domain containing 3 (NLRP3) inflammasome activation an important source IL-1β. As anti-inflammatory neuroendocrine hormone, melatonin plays various roles in different pathophysiological conditions. However, its IVDD are still not well understood require more examination. First, we demonstrated that delayed...
Percutaneous vertebroplasty (PVP) and percutaneous balloon kyphoplasty (PKP) can increase bone strength as well alleviate the pain caused by vertebral compression fractures (VCFs), both procedures rely on polymethyl methacrylate (PMMA) cement injected into fractured vertebra for mechanical stabilization of VCFs. However, there is debate over which these 2 surgical give better short-term long-term outcomes. A lot studies meta-analysis were designed to assess advantages drawbacks PKP PVP in...
Circular RNAs (circRNAs) play important roles in the initiation and development of different diseases. Here, we detected their role intervertebral disc (IVD) degeneration. An Arraystar human circular RNA microarray assay was used to detect circRNAs normal degenerated IVD nucleus pulposus (NP) tissues. The circ-4099 IVDD its mechanism were evaluated by qRT-PCR gain-of-function/loss-of-function studies. Interaction networks for competing endogenous (ceRNAs), miRNAs, miRNA target gene...
The objective of this study was to investigate the regulatory effects TGF-β1 on CCL3/4 expression and inflammation-related pain during intervertebral disc degeneration (IVDD). patterns in different degenerative human nucleus pulposus (NP) tissues were measured by qPCR immunohistochemistry (IHC), qPCR, ELISA immunofluorescence. roles NF-κB MAPK TGF-β1-mediated promoter activity studied using siRNAs, western blotting qPCR. After establishing an IVDD rat model vivo, we administered intradiscal...
Intervertebral disc degeneration (IVDD) is a main cause of low back pain, and inflammatory factors play key roles in its pathogenesis. Gremlin-1 (Grem1) was reported to induce an response other fields. This study aimed investigate the mechanisms Grem1 degenerative process intervertebral discs. Dysregulated genes were determined by analyzing microarray profiles. The expression 17 human samples (male:female = 9:8) rat models (n 5 each group) measured western blotting (WB), real-time...
Abstract Fibrotic remodeling of nucleus pulposus (NP) leads to structural and mechanical anomalies intervertebral discs that prone degeneration, leading low back pain incidence disability. Emergence fibroblastic cells in disc degeneration has been reported, yet their nature origin remain elusive. In this study, we performed an integrative analysis multiple single-cell RNA sequencing datasets interrogate the cellular heterogeneity fibroblast-like entities degenerative human NP specimens. We...
Abstract Background/objectives As a proinflammatory cytokine, interleukin-17 (IL-17) contributes to the inflammation of many autoimmune diseases. We examined IL-17 levels in serum and tissues from patients with chronic hepatitis B virus infection (HBV), especially evaluated role pathogenesis progression liver fibrosis. Materials methods Whole venous blood was obtained four patient groups: (CHB, n = 47), cirrhosis (LC, 49), primary hepatocellular carcinoma (PHC, 44), failure (CLF, 33), normal...
In Brief Study Design. An in vitro laboratory study. Objective. (i) To evaluate the effect of osteoporotic degree determining strength sacral screw fixation and (ii) to compare unaugmented bicortical pedicle polymethylmethacrylate (PMMA) augmented unicortical fixation. Summary Background Data. Screw loosening is a clinical problem lumbosacral fusions, especially patients. improve anchoring sacrum, PMMA techniques are widely used practice. However, biomechanical fixations remains undetermined...
ABSTRACT The aim of this study was to analyze the relationship between intervertebral disc degeneration and low back pain (LBP). Rat L4/5 model established by annular puncture using a 0.4 mm needle anteriorly or posteriorly. In both anterior posterior models, magnetic resonance imaging (MRI) histological analyses revealed marked 2 weeks after puncture. Cytokine expression up‐regulated in different level nucleus pulposus (NP) from 3 days Pain behavioral tests indicated that did not induce...
An international, multicenter cross-sectional image-based study performed in 33 institutions the Asia Pacific region.The addressed role of facet joint angulation and tropism relation to L4-L5 degenerative spondylolisthesis (DS).The included 349 patients (63% females; mean age: 61.8 years) with single-level DS; 82 had no DS (group A) 267 B). Axial computed tomography magnetic resonance imaging were utilized assess angulations (i.e., asymmetry between angulations) groups.There was a...