A5051744476- Spine and Intervertebral Disc Pathology
- Musculoskeletal pain and rehabilitation
- Spinal Fractures and Fixation Techniques
- Scoliosis diagnosis and treatment
- Pelvic and Acetabular Injuries
- Pregnancy-related medical research
- Hepatocellular Carcinoma Treatment and Prognosis
- Medical Imaging and Analysis
- Metal complexes synthesis and properties
- Spinal Hematomas and Complications
- Cancer-related molecular mechanisms research
- Magnetism in coordination complexes
- Renal cell carcinoma treatment
- Circular RNAs in diseases
- Electron Spin Resonance Studies
- Colorectal Cancer Screening and Detection
- Orthopaedic implants and arthroplasty
- Heme Oxygenase-1 and Carbon Monoxide
- Gastric Cancer Management and Outcomes
- Ferroptosis and cancer prognosis
- Spectroscopy and Quantum Chemical Studies
- Hair Growth and Disorders
- Cancer Immunotherapy and Biomarkers
- Management of metastatic bone disease
- Osteoarthritis Treatment and Mechanisms
The First Affiliated Hospital, Sun Yat-sen University
2016-2025
Sun Yat-sen University
2016-2025
Key Laboratory of Guangdong Province
2021-2025
Zhongshan Hospital
2009-2022
Hubei University of Medicine
2021-2022
Shanghai Medical College of Fudan University
2022
First Affiliated Hospital of Henan University
2021
Xian Yang Central Hospital
2019
Second Hospital of Shanxi Medical University
2019
Shanxi Medical University
2019
Percutaneous vertebroplasty (PVP) and percutaneous balloon kyphoplasty (PKP) can increase bone strength as well alleviate the pain caused by vertebral compression fractures (VCFs), both procedures rely on polymethyl methacrylate (PMMA) cement injected into fractured vertebra for mechanical stabilization of VCFs. However, there is debate over which these 2 surgical give better short-term long-term outcomes. A lot studies meta-analysis were designed to assess advantages drawbacks PKP PVP in...
Abstract Intervertebral disc degeneration is a natural process during aging and leading cause of lower back pain. Here, we generate comprehensive atlas nucleus pulposus cells using single-cell RNA-seq analysis human tissues (three males four females, age 41.14 ± 18.01 years). We identify fibrotic late-stage characterized by upregulation serglycin expression which facilitate the local inflammatory response promoting infiltration cytokines macrophages. Finally, discover that daphnetin,...
Inadequate tendon healing and heterotopic bone formation result in substantial pain disability, yet the specific cells responsible for remain uncertain. Here we identify a CD26+ stem/progenitor residing peritendon, which constitutes primitive stem cell population with self-renewal multipotent differentiation potentials. migrate into midsubstance tenocytes during healing, while ablation of these led to insufficient healing. Additionally, contribute ossification Tenascin-C-Hippo signaling is...
Intervertebral disc degeneration (IVDD) is a main cause of low back pain, and inflammatory factors play key roles in its pathogenesis. Gremlin-1 (Grem1) was reported to induce an response other fields. This study aimed investigate the mechanisms Grem1 degenerative process intervertebral discs. Dysregulated genes were determined by analyzing microarray profiles. The expression 17 human samples (male:female = 9:8) rat models (n 5 each group) measured western blotting (WB), real-time...
The aim of this study was to evaluate the effects rod stiffness and implant density on coronal sagittal plane correction in patients with main thoracic curve adolescent idiopathic scoliosis (AIS).The authors conducted a retrospective 77 consecutive cases involving 56 female 21 male Lenke Type 1 AIS who underwent single-stage posterior instrumented spinal fusion pedicle screw fixation between July 2009 2012. patients' mean age at surgery 15.79 ± 3.21 years. All had least year follow-up....
Peroral endoscopic myotomy (POEM) has been developed as a minimally invasive treatment for achalasia years. However, the optimal length of submucosal tunnel and muscle bundles during procedure POEM not yet determined, so we aim to assess safety efficacy modified with shorter in patients. Consecutive patients had performed myotomy, assessed by symptoms, high-resolution manometry, barium swallow examinations before 3 months after evaluation. Modified (mean 6.8 cm) (total mean 5.4 were...
Abstract Background Intervertebral disc degeneration (IVDD)-related disorders are the major causes of low back pain. A previous study suggested that Notch activation serves as a protective mechanism and is part compensatory response maintains necessary resident nucleus pulposus (NP) cell proliferation to replace lost or non-functional cells. However, exact remains be determined. In this study, we aimed investigate role JAG2/Notch2 in NP apoptosis. Methods Recombinant JAG2 Notch2, Hes1, Hey2...
A hybrid optical microcavity from rolled-up polymer/oxide/polymer nanomembranes presents its excellent capability for environmental relative humidity detection. When exposed to a moist surrounding, poly(acrylic acid)/poly(ethylenimine) polymers swell greatly due the absorption of water molecules, which thus leads an increased wall thickness tubular and therefore profound wavelength redshift whispering-gallery mode resonance. These experiments fit well with calculation based on Mie-scattering...
Study Design A prospective cross-sectional study. Purpose To evaluate the risk factors associated with severity of pain intensity in patients non-specific low back (NSLBP) Southern China. Overview Literature Low (LBP) is leading cause activity limitation and work absence throughout world, so a firm understanding factor NSLBP can provide early prompt interventions that are aimed at attaining long-term results. Methods Participants were recruited from January 2014 to 2016 surveyed using...
Visfatin reportedly induces the expression of proinflammatory cytokines. Severe grades intervertebral disc disease (IVDD) exhibit higher visfatin than mild ones. However, direct relationship between and IVDD remains to be elucidated. This study aimed clarify whether stimulation in is mediated by IL-6. To investigate role IVDD, a rat model anterior puncture was established injecting or PBS using 27-gauge needle. Results revealed an obvious aggravation histological morphology group. On...
An in vitro biomechanical study of 3 lumbosacral fixation techniques human cadaveric lumbar-pelvic spine models.To compare the effect a novel 4-rod reconstruction technique with conventional lumbopelvic model, and to evaluate benefit adding supplementary rod fixation.Spinopelvic involving sacrum remains difficult clinical challenge. Numerous methods based on Galveston 2-rod have been proposed. Recently, using supporting longitudinal rods across junction was reported. However, no comparative...
rs12979860 in interleukin 28B (IL28B) gene is associated with response to interferon‐α therapy and natural viral clearance hepatitis C. The role of this polymorphism less known B virus (HBV) infection. We evaluated whether was outcomes HBV There were 651 individuals persistent infection (387 liver cirrhosis, 264 without cirrhosis) 226 healthy who recovered from genotypic distributions compared between different phenotypes pertaining disease progression markers. had no association surface...
Intervertebral disc degeneration (IVDD) is a leading cause of low back pain. Circular RNAs (circRNAs) have been demonstrated to exert vital functions in IVDD. However, the role and mechanism hsa_circ_0083756 development IVDD remain unclear.RT-qPCR was performed detect expressions hsa_circ_0083756, miR-558 TREM1 nucleus pulposus (NP) tissues cells. CCK8 assay, flow cytometry, TUNEL RT-qPCR WB were used clarify roles NP cells proliferation extracellular matrix (ECM) formation. Bioinformatics...