A5028109081- Genetic diversity and population structure
- Identification and Quantification in Food
- Rice Cultivation and Yield Improvement
- Genetic Mapping and Diversity in Plants and Animals
- Epigenetics and DNA Methylation
- melanin and skin pigmentation
- Smart Agriculture and AI
- Heat shock proteins research
- Cancer-related molecular mechanisms research
- Remote Sensing in Agriculture
- Bee Products Chemical Analysis
- Endoplasmic Reticulum Stress and Disease
- Marine and coastal plant biology
- Histone Deacetylase Inhibitors Research
- Web Data Mining and Analysis
- Atherosclerosis and Cardiovascular Diseases
- RNA Research and Splicing
- Remote Sensing and LiDAR Applications
- Healthcare and Venom Research
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Simulation and Modeling Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Plant responses to water stress
- MicroRNA in disease regulation
Shanghai University of Medicine and Health Sciences
2025
Air Force Medical University
2016-2025
Anhui Agricultural University
2022-2025
Northwest A&F University
2025
Ocean University of China
2008-2024
Bohai University
2024
Bengbu Medical College
2024
Huashan Hospital
2024
Fudan University
2024
China University of Geosciences
2021-2023
Abstract Changes in atmospheric CO 2 concentration have played a central role algal and plant adaptation evolution. The commercially important red genus, Pyropia (Bangiales) appears to responded inorganic carbon (C i ) availability by evolving alternating heteromorphic generations that occupy distinct habitats. leafy gametophyte inhabits the intertidal zone undergoes frequent emersion, whereas sporophyte conchocelis bores into mollusk shells. Here, we analyze high-quality genome assembly of...
Salt-inducible kinase 2 (SIK2) has been established as a regulator of diverse biological processes including cell metabolism. A recent study reported that SIK2 is required for adipocyte-induced ovarian cancer (OC) survival through facilitating fatty acid oxidation. However, whether also plays role in the lipid synthesis OC cells remains elusive. Here, we showed significantly promoted cells. On one hand, enhanced upregulating expression sterol regulatory element binding protein 1c (SREBP1c)...
The global issue of insecticide resistance among pests is a major concern. Ectropis grisescens Warren (Lepidoptera: Geometridae), highly destructive leaf-eating pest distributed in tea plantations throughout China and Japan, has exhibited to various insecticides. Recent studies suggest that insect symbionts play role influencing resistance, however, their specific involvement E. remains unclear. Here, we initially selected appropriate antibiotic mixtures at concentration 300 μg ml
Abstract MicroRNA is responsible for the fine-tuning of fundamental cellular activities and human disease development. The altered availability microRNAs, target mRNAs, other types endogenous RNAs competing microRNA interactions reflects dynamic conditional property microRNA-mediated gene regulation that remains under-investigated. Here we propose a new integrative method to study this process by considering both cooperative mechanisms identifying functional modules where different microRNAs...
Heat shock protein 90 (Hsp90) is a highly abundant eukaryotic molecular chaperone that plays important roles in client maturation, folding and degradation, signal transduction. Previously, we found both Hsp90 its co-chaperone cell division cycle 37 (Cdc37) were expressed human sperm. known to be involved sperm capacitation via unknown underlying mechanism(s). As Cdc37 was kinase-specific of Hsp90, may regulate other kinases. It has been reported two major mitogen-activated kinases (MAPKs),...
The nucleus pulposus is in a hypoxic environment the human body, and when intervertebral disc degeneration (IVDD) occurs, disrupted. Nucleus cell (NPC) ferroptosis one of causes IVDD. N6-methyladenosine (m6A) its reader protein YTHDF1 regulate cellular activities by affecting RNA metabolism. However, regulation NPCs m6A-modified RNAs under conditions has not been as well studied. In this study, through vitro vivo experiments, we explored underlying mechanism HIF-1α regulating NPCs. results...
Abstract H1 histamine receptor (H1HR) belongs to the family of rhodopsin-like G-protein-coupled receptors. Recent studies have shown that H1HR expression is increased in several types cancer. However, its functional roles tumor progression remain largely unknown, especially hepatocellular carcinoma (HCC). We found frequently unregulated HCC, which significantly associated with both recurrence-free survival and overall HCC patients. Functional experiments revealed promoted growth metastasis...
Existing AU detection algorithms are mainly based on appearance information extracted from 2D images, and well-established facial biomechanics that governs 3D skin deformation is rarely considered. In this paper, we propose a biomechanics-guided approach, where muscle activation forces modelled employed to predict activation. Specifically, our model consists of two branches: physics branch image branch. branch, first derive the Euler-Lagrange equation governing deformation. The represented...
Neutrophil infiltration has been linked to worse clinical outcomes after ischemic stroke. Microglia, a key type of immune-competent cell, engage in cross-talk with the infiltrating immune cells inflamed brain area, yet molecular mechanisms involved remain largely unexplored. In this study, we investigated how canonical transient receptor potential 1 (TRPC1) modulated neutrophil male mouse cerebral ischemia and reperfusion injury (CIRI) models. Our findings revealed notable upregulation TRPC1...
Mitochondria are key regulators in cell proliferation and apoptosis. Alterations mitochondrial function closely associated with inflammation tumorigenesis. This study aimed to investigate whether transcription factor A (TFAM), a regulator of DNA replication, is involved the initiation progression colitis-associated cancer (CAC).TFAM expression was examined tissue samples inflammatory bowel diseases (IBD) CAC by immunohistochemistry. Intestinal epithelial (IEC)-specific TFAM-knockout mice...
Recent advances in image-based plant phenotyping have improved our capability to study vegetative stage growth dynamics. However, more complex agronomic traits such as inflorescence architecture (IA), which predominantly contributes grain crop yield are challenging quantify and hence relatively less explored. Previous efforts estimate inflorescence-related using been limited destructive end-point measurements. Development of non-destructive platforms could accelerate the discovery phenotypic...
The use of 3D plant models for high-throughput phenotyping is increasingly becoming a preferred method many science researchers. Numerous camera-based imaging systems and reconstruction algorithms have been developed the plants. However, it still challenging to build an system with high-quality results at low cost. Useful comparative information existing their improvements also limited, making researchers make data-based selections. objective this study explore possible solutions address...
Abstract Water deficit during the early vegetative growth stages of wheat (Triticum) can limit shoot and ultimately impact grain productivity. Introducing diversity in cultivars to enhance range phenotypic responses water limitations provide potential avenues for mitigating subsequent yield losses. We tested this hypothesis an elite durum background by introducing a series introgressions from wild emmer (Triticum turgidum ssp. dicoccoides) wheat. Wild populations harbor rich drought-adaptive...
Abstract Background Heat shock protein 90 (Hsp90) signaling pathways participate in phosphorylation during sperm capacitation. However, the underlying mechanism is largely unknown. Objective The aim of this study was to explore interaction between Hsp90 and its co‐chaperone protein, cell division cycle Cdc37 (Cdc37), human spermatozoa. Materials methods We examined effects H‐89 (a kinase A [PKA] inhibitor) Go6983 C [PKC] on serine, threonine, tyrosine residues Hsp90; effect...
Heat shock protein 20 ( Hsp20 ) genes play important roles in plant growth, development, and response to environmental stress. However, the gene family has not yet been systematically investigated, its function red algae (Rhodophyta) remains poorly understood. Herein, we characterized families by studying structure, conserved motifs, phylogenetic relationships, chromosome location, duplication, cis- regulatory elements, expression profiles. In this study, 97 were identified using...
Microglial canonical transient receptor potential channel 1 (TRPC1) has been proposed to influence neuroinflammation after cerebral ischemia and reperfusion injury (CIRI), however, the underlying mechanism remains poorly understood. This study demonstrates that TRPC1 is modified by small ubiquitin-related modifier (SUMO)ylation. Our findings suggest a notable increase in microglial SUMOylation within both middle artery occlusion (MCAO/R) model vitro oxygen-glucose deprivation/regeneration...
Hepatocellular carcinoma (HCC) is a severe disease associated with poor prognosis. The role of aberrant lipid metabolism in the development and progression HCC necessitates detailed characterization. Sterol regulatory element‑binding proteins (SREBPs), pivotal transcription factors governing lipogenesis, are central to this process. present study aimed assess regulation by SREBP signaling pathway, examining expression levels genes clinical implications its prognostic value using Kaplan‑Meier...