A5101526191- Cancer, Hypoxia, and Metabolism
- Mitochondrial Function and Pathology
- ATP Synthase and ATPases Research
- Liver physiology and pathology
- Peroxisome Proliferator-Activated Receptors
- Cancer, Lipids, and Metabolism
- Hepatocellular Carcinoma Treatment and Prognosis
- Uterine Myomas and Treatments
- Heat shock proteins research
- Endometriosis Research and Treatment
- Reproductive System and Pregnancy
- MicroRNA in disease regulation
- RNA modifications and cancer
- Chromosomal and Genetic Variations
- Autophagy in Disease and Therapy
- Cancer-related molecular mechanisms research
- Genomics and Phylogenetic Studies
- Liver Disease Diagnosis and Treatment
- Circadian rhythm and melatonin
- Cholesterol and Lipid Metabolism
- Macrophage Migration Inhibitory Factor
- Genetics, Aging, and Longevity in Model Organisms
- Pancreatic and Hepatic Oncology Research
- Brain Metastases and Treatment
- Management of metastatic bone disease
Shuguang Hospital
2025
Shanghai University of Traditional Chinese Medicine
2025
Chongqing Medical University
2024
Second Affiliated Hospital of Chongqing Medical University
2024
Xinxiang Medical University
2023-2024
Dalian Medical University
2024
Air Force Medical University
2012-2022
Applied Radar (United States)
2021
Signal Processing (United States)
2021
Cloud Computing Center
2021
Tumor-associated macrophages (TAMs) contribute to hepatocellular carcinoma (HCC) progression. However, the molecular mechanism underlying infiltration of TAMs into HCC microenvironment is largely unclear. Recent studies have reported that alteration mitochondrial nucleoid structures induces DNA (mtDNA) release cytosol, which recognized as mtDNA stress, and consequently regulates innate immunity. Here we aimed investigate whether fission stress then promotes TAM Confocal microscopy real-time...
Salt-inducible kinase 2 (SIK2) has been established as a regulator of diverse biological processes including cell metabolism. A recent study reported that SIK2 is required for adipocyte-induced ovarian cancer (OC) survival through facilitating fatty acid oxidation. However, whether also plays role in the lipid synthesis OC cells remains elusive. Here, we showed significantly promoted cells. On one hand, enhanced upregulating expression sterol regulatory element binding protein 1c (SREBP1c)...
Abstract Background Mitochondria are dynamic organelles that constantly change their morphology through fission and fusion processes. Recently, abnormally increased mitochondrial has been observed in several types of cancer. However, the functional roles lipid metabolism reprogramming cancer cells remain unclear. This study aimed to explore role hepatocellular carcinoma (HCC) cells. Methods Lipid was determined by evaluating changes expressions core metabolic enzymes intracellular content....
Abstract Emerging evidences show that disruption of the circadian rhythm is associated with tumor initiation and progression. Neuronal PAS domain protein 2 (NPAS2), one core molecules, has been proved to be a potential prognostic biomarker in colorectal breast cancers. However, date, functional roles molecular mechanisms by which NPAS2 affects cancer cell survival are greatly unclear, especially hepatocellular carcinoma (HCC). We first investigated expression its clinical significance HCC....
The circadian clock confers daily rhythmicity to many crucial biological processes and behaviors its disruption is closely associated with carcinogenesis in several types of cancer.Brain muscle arnt-like protein 1 (BMAL1) a core rhythm component mammals dysregulation has been shown contribute aberrant metabolism human diseases.However, the functions BMAL1, especially involvement lipid hepatocellular carcinoma (HCC), remain elusive.In present study, we found that BMAL1 was frequently...
Levels of the mitochondrial calcium uniporter regulator 1 (MCUR1) increases during development hepatocellular carcinoma (HCC). However, mechanisms how Ca2+ homeostasis is modulated and its function remain limited in cancers.MCUR1 was frequently upregulated HCC cells to enhance uptake into mitochondria an MCU-dependent manner, which significantly facilitated cell survival by inhibiting mitochondria-dependent intrinsic apoptosis promoting proliferation cells, thus led poor prognosis. In vivo...
Although previous evidence indicates close involvement of CD147 in the pathogenesis liver fibrosis, underlying molecular mechanisms and its therapeutic value remain largely unknown. In present study, we investigated biological roles fibrosis assessed as a target molecule CCl4-induced mouse model. We found that was highly expressed both hepatocytes SECs (sinusoidal endothelial cells) fibrotic tissues. Additionally, it significantly associated with stage. TGF-β1 (transforming growth factor β1)...
// Jing Zhang 1, * , Xingchun Zhou Hulin Chang 2, Xiaojun Huang 1 Xu Guo Xiaohong Du Siyuan Tian Lexiao Wang Yinghua Lyv Peng Yuan 3 Jinliang Xing State Key Laboratory of Cancer Biology and Experimental Teaching Center Basic Medicine, Fourth Military Medical University, Xi'an, Shaanxi, China 2 Department Hepatobiliary Surgery, Shaanxi Provincial People’s Hospital, Xi’an, Pain Treatment, Tangdu Zhang, contributed equally to this work Correspondence to: Xing, email:...
Abstract Background and Aim It was commonly accepted that chemotherapeutic cytotoxicity the main cause for hepatic failure in hepatocellular carcinoma patients after repeated transarterial chemoembolization ( TACE ). However, effect of embolization‐induced hypoxia on liver cirrhosis has rarely been concerned. Methods Serum levels alanine aminotransferase, aspartate albumin were used to detect injury. Hepatic artery ligation performed carbon tetrachloride‐induced rat fibrosis model mimic . S...
Abstract Solute carrier family 25 member 20 (SLC25A20) is a mitochondrial-membrane–carrier protein involved in the transport of acylcarnitines into mitochondrial matrix for oxidation. A previous-integrated-proteogenomic study had identified SLC25A20 as one top-three prognostic biomarkers HCC. However, expression and biological function have not yet been investigated In present study, we found that frequently down-regulated HCC cells mainly due to up-regulation miR-132-3p. Down-regulation...
To evaluate the angiogenic inhibitory effects of an alpha(v)beta(3)/alpha(v)beta(5) integrin antagonist, EMD478761, released from a polymeric implant in chick chorioallantoic membrane (CAM) assay and laser-induced experimental choroidal neovascularization (CNV) rats.Polyvinyl alcohol-based reservoir implants releasing EMD478761 were designed for placement onto CAM or intravitreally rats. In vitro release rates measured using HPLC. Angiogenesis was induced on 10-day-old embryos by basic...
The functional abnormality of circadian regulation genes is involved in the development and progression hepatocellular carcinoma (HCC). However, association between single nucleotide polymorphisms (SNPs) gene NPAS2 overall survival HCC patients treated with transcatheter arterial chemoembolization (TACE) has never been investigated. Six SNPs were genotyped using Sequenom iPLEX genotyping system a cohort 448 unresectable Chinese TACE. Multivariate Cox proportional hazards model Kaplan-Meier...
BACKGROUNDEndometriosis is a chronic disease that responds to systemic pseudo-pregnancy therapy. However, side effects limit their long-term use, and recurrence often occurs after cessation of medication. Reducing whereas improving therapeutic efficacy therapy seems contradictory, but appealing. In order address this dilemma, the local were investigated for first time in an endometriosis animal model.
The use of the common anticancer drug cisplatin (CP) in clinical practice often leads to acute kidney injury (AKI); however, no protective therapy is available. Therefore, new drugs that reduce nephrotoxicity induced by CP are urgently needed. Carnosol (CA) an antioxidant found. We investigated renoprotective effects CA on CP-induced AKI male C57BL/6 mice and HK2 cells. mitigated renal dysfunction, histopathological changes tubular vivo, as indicated expression NGAL, KIM1 HMGB1. Moreover,...
Abstract Acyl‐CoA thioesterase 9 (ACOT9) is a critical regulator of cellular utilization fatty acids by catalysing the hydrolysis acyl‐CoA thioesters to non‐esterified acid and coenzyme A (CoA). Recently, ACOT9 was reported participate in pathogenesis non‐alcoholic liver disease (NAFLD), which arises from aberrant lipid metabolism serves as risk factor for hepatocellular carcinoma (HCC). However, functions carcinogenesis HCC remain unexplored. Here, we found that expression significantly...