A5020794809- Cholesterol and Lipid Metabolism
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Natural product bioactivities and synthesis
- Ginger and Zingiberaceae research
- Smart Agriculture and AI
- Liver physiology and pathology
- Epigenetics and DNA Methylation
- Microbial Metabolic Engineering and Bioproduction
- Fermentation and Sensory Analysis
- Oral microbiology and periodontitis research
- Biochemical and biochemical processes
- Cancer, Lipids, and Metabolism
- Nanoparticles: synthesis and applications
- Sesquiterpenes and Asteraceae Studies
- Fungal Plant Pathogen Control
- Fatty Acid Research and Health
- ATP Synthase and ATPases Research
- Protein Tyrosine Phosphatases
- Spectroscopy and Chemometric Analyses
- Pulmonary Hypertension Research and Treatments
- Lipid metabolism and disorders
- Dental Erosion and Treatment
- Moringa oleifera research and applications
Shandong First Medical University
2019-2025
Shandong Provincial QianFoShan Hospital
2021-2025
Shenzhen University
2020-2024
Henan Normal University
2024
People's Liberation Army 401 Hospital
2020-2023
Air Force Medical University
2011-2023
Oregon State University
2023
Ministry of Agriculture and Rural Affairs
2022
Zhejiang University
2020-2022
Hainan Maternal and Child Health Hospital
2022
Anti-obesity activity of tea water extracts is partially mediated by altering intestinal microbiota <italic>via</italic> suppressing production LPS and promoting SCFAs.
Previous studies have shown that short-chain fatty acids (SCFAs) are capable of decreasing plasma cholesterol. However, the relative plasma-cholesterol-lowering activity individual SCFAs and underlying mechanisms by which decrease cholesterol remain largely unknown. The present study was done to compare potencies four common with 2-5 carbons investigate their interactions gene expressions key regulatory factors involved in metabolism. For 6 weeks, five groups male Golden hamsters were fed...
Abstract Background Mitochondria are dynamic organelles that constantly change their morphology through fission and fusion processes. Recently, abnormally increased mitochondrial has been observed in several types of cancer. However, the functional roles lipid metabolism reprogramming cancer cells remain unclear. This study aimed to explore role hepatocellular carcinoma (HCC) cells. Methods Lipid was determined by evaluating changes expressions core metabolic enzymes intracellular content....
Previous research has shown that Tartary buckwheat flour is capable of reducing plasma cholesterol. The present study was to examine the effect rutin and protein on total cholesterol (TC) in hypercholesterolemia hamsters. In first animal experiment, 40 male hamsters were divided into four groups fed either control diet or one three experimental diets containing 8.2 mmol rutin, quercetin, 2.5 g kg-1 cholestyramine, respectively. Results showed only cholestyramine but not its aglycone...
Abstract Bacillus subtilis strain B7-S screened from18 strains is an aerobic, endospore-forming, model organism of Gram-positive bacteria which capable to form vanillin during ferulic acid bioconversion. The bioconversion by ( B. B7-S) was investigated. Based on our results, the optimum conditions for production can be summarized as follows: temperature 35 °C; initial pH 9.0; inoculum volume 5%; concentration 0.6 g/L; culture medium 20%; and shaking speed 200 r/min. Under these conditions,...
Abstract We performed the biotransformation of ferulic acid to vanillin using Bacillus subtilis ( B. ) in stirring packed-bed reactors filled with carbon fiber textiles (CFT). Scanning electron microscope (SEM), HPLC, qRT-PCR and ATP assay indicated that is tightly related cell growth, cellar activity extent biofilm formation. The was affected by hydraulic retention time (HRT), temperature, initial pH, speed concentration, maximum production obtained at 20 h, 35 °C, 9.0, 200 rpm, 1.5 g/L,...
Engineered zinc oxide nanoparticles (ZnO-NPs) are currently being produced in high tonnage. Exposure to ZnO-NPs presents potential risks cardiovascular system. Thus far, the toxicological effects of on system have not been well characterized. In this study, human coronary artery endothelial cells (HCAECs) were exposed directly or indirectly using a transwell coculture with alveolar epithelial cell line A549 mimic lung/circulation interaction. It was shown that levels proinflammatory...
Of the many factors known to influence rate of electron transfer between two metalloproteins, it is particularly difficult assess role polypeptide matrix intervening donor and acceptor sites. To determine whether phylogenetically conserved Phe-87 yeast iso-1-cytochrome c helps mediate cytochrome peroxidase, we have constructed mutants that are altered at this position now studied kinetics long-range within their complexes with zinc-substituted peroxidase. We find from reduced zinc peroxidase...
Statins are 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductase inhibitors widely used in the treatment of hyperlipidemia. The inhibition HMG-CoA mevalonate pathway leads to suppression cell proliferation and induction apoptosis. cyclic GMP-AMP synthase (cGAS) stimulator interferon genes (STING) signaling has been suggested not only facilitate inflammatory responses production type I interferons (IFN), but also activate other cellular processes, such as It studied, however, whether...
Eudesmane-type sesquiterpenes are natural with anti-inflammatory properties, but their anti-angiogenic activities not known. The present study demonstrated that 5α-hydroxycostic acid and hydroxyisocostic acid, two eudesmane-type (ETSs), isolated from the herb Laggera alata, possessed effects. Under non-toxic dosage, ETSs suppressed VEGF‑induced proliferation in human umbilical vein endothelial cells (HUVECs) vessel formation zebrafish embryos. Moreover, inhibited VEGF-stimulated HUVEC...
The promising therapeutic outcomes of neoadjuvant immunotherapy with chemotherapy (NAIC) in the treatment resectable locally advanced esophageal squamous cell carcinoma (LA-ESCC) have been confirmed by several clinical trials. However, potential benefits adjuvant therapy for LA-ESCC patients remain unclear. We analyzed underwent NAIC and between January 2020 September 2023. effectiveness feasibility were evaluated. A total 112 included. With a median follow-up 24.0 months, all had an R0...
e16146 Background: The promising therapeutic outcomes of neoadjuvant immunotherapy with chemotherapy (NAIC) in the treatment resectable locally advanced esophageal squamous cell carcinoma (LA-ESCC) have been confirmed by several clinical trials. However, potential benefits adjuvant therapy for LA-ESCC patients remain unclear. Methods: We analyzed underwent NAIC and between January 2020 September 2023. effectiveness feasibility were evaluated. Results: A total 112 ESCC included. With a median...
Abstract Gasdermin D (GSDMD)‐induced pyroptosis is associated with inflammatory disease. However, the role of GSDMD in acute pancreatitis (AP) not yet fully elucidated. This study reveals that serves two distinct functions pancreatic acinar cells and macrophages. In cells, inhibits synthesis enzyme by downregulating expression Prss1, Pnlip, Amy1 via inhibition protein kinase B (AKT)/mammalian target rapamycin (mTOR)/ribosomal S6 (RPS6)/eukaryotic translation initiation factor 4E‐binding 1...
Three new quinic acid derivatives, 4-<i>O</i>-caffeoyl-3-<i>O</i>-sinapoylquinic methyl ester (<b>1</b>), 5-<i>O</i>-caffeoyl-4-<i>O</i>-syringoylquinic (<b>2</b>), and 4-<i>O</i>-caffeoyl-3-<i>O</i>-syringoylquinic (<b>3</b>), as well four coumarin glycosides, 7-<i>O</i>-(3-<i>O</i>-sinapoyl-<i>β</i>-<sc>D</sc>-glucopyranosyl)-6-methoxycoumarin (<b>12</b>), 7-<i>O</i>-(6-<i>O</i>-sinapoyl-<i>β</i>-<sc>D</sc>-glucopyranosyl)-6-methoxycoumarin (<b>13</b>),...