A5100725247- Mesenchymal stem cell research
- Autophagy in Disease and Therapy
- Proteoglycans and glycosaminoglycans research
- Potato Plant Research
- Helicobacter pylori-related gastroenterology studies
- Cancer-related molecular mechanisms research
- Gut microbiota and health
- Neurological Disease Mechanisms and Treatments
- Neurogenesis and neuroplasticity mechanisms
- Fibroblast Growth Factor Research
- Mycobacterium research and diagnosis
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Neurological Disorders and Treatments
- Pluripotent Stem Cells Research
- Heavy Metal Exposure and Toxicity
- Sleep and Wakefulness Research
- RNA Interference and Gene Delivery
- Vagus Nerve Stimulation Research
- Animal Nutrition and Physiology
- Pharmacological Receptor Mechanisms and Effects
- Phytochemical Studies and Bioactivities
- Axon Guidance and Neuronal Signaling
- NF-κB Signaling Pathways
Shanghai University of Traditional Chinese Medicine
2022-2025
The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture
2023-2024
State Ethnic Affairs Commission
2023-2024
Yunnan Agricultural University
2023-2024
Shandong First Medical University
2024
Xinqiao Hospital
2018-2023
Army Medical University
2016-2023
Shandong Transportation Research Institute
2023
Chengdu University
2023
Hubei Normal University
2023
Inflammatory bowel disease (IBD) is a global health problem in which gut microbiota dysbiosis plays an important pathogenic role.However, the current drugs for IBD treatment are far from optimal.Previous researches indicated that parthenolide (PTL) had not only anti-cancer properties but also strong anti-inflammatory activities.Rationale: To investigate protective effect of PTL on colon inflammation and demonstrate underlying microbiota-dependent mechanism.Methods: Colon severity mouse model...
Abstract Background Well-balanced interactions between gut microbiota and the immune system are essential to prevent chronic intestinal inflammation, as observed in inflammatory bowel diseases (IBD). Toll-like receptor 4 (TLR4) functions a sensor mediating crosstalk commensal microbiome host immunity, but influence of TLR4 on shaping responses during colon inflammation remains poorly characterized. We investigated whether different susceptibilities colitis wild-type (WT) −/− mice were...
Abstract Background The endoglycosidase heparanase which degrades heparan sulfate proteoglycans, exerts a pro-inflammatory mediator in various inflammatory disorders. However, the function and underlying mechanism of acute pancreatitis remain poorly understood. Here, we investigated interplay between gut microbiota development pancreatitis. Methods Acute was induced wild-type heparanase-transgenic mice by administration caerulein. differences were analyzed 16S ribosomal RNA sequencing....
Cadmium (Cd), a highly ubiquitous heavy metal, induces neurotoxicity. Melatonin, major secretory product of the pineal gland, protects against Cd-induced However, mechanism that accounts for this protection remains to be elucidated. Herein, we exposed mouse neuroblastoma cells (Neuro-2a cells) different concentrations cadmium chloride (CdCl2 ) (12.5, 25, and 50 μ mol L(-1) 24 hours. We showed Cd inhibits autophagosome-lysosome fusion impairs lysosomal function, subsequently leading nerve...
Nonalcoholic fatty liver disease (NAFLD) is one of the most prevalent diseases worldwide. Exercise a first‐line therapy and an important preventive measure for patients with NAFLD, but underlying mechanisms are not clear. C57BL/6 mice were fed high‐fat diet (HFD) subjected to 12 wk swimming exercise. protected against hepatic lipid accumulation alleviated hepatocyte damage in HFD mice. Tandem mass tag—based quantitative proteomic analyses ingenuity pathway analysis revealed that exercise...
Cadmium (Cd) is a toxic metal that widely found in numerous environmental matrices and induces serious adverse effects various organs tissues. Bone tissue seems to be crucial target of Cd contamination. Macroautophagy/autophagy has been proposed play pivotal role Cd-mediated bone toxicity. However, the mechanisms underlie Cd-induced autophagy are not yet completely understood. We demonstrated treatment increased autophagic flux inhibition process using Atg7 gene silencing blocked mesenchymal...
Chronic gastritis caused by Helicobacter pylori ( H. ) infection has been widely recognized as the most important risk factor for gastric cancer. Analysis of interaction between key participants in mucosal immunity and is expected to provide insights treatment chronic prevention Heparanase an endoglycosidase that degrades heparan sulfate, resulting remodeling extracellular matrix thereby facilitating extravasation migration immune cells towards sites inflammation. also releases sulfate-bound...
Poultry is a source of meat that in great demand the world. The quality an imperative point for shoppers. To explore genes controlling characteristics, growth and traits muscle transcriptome two indigenous Yunnan chicken breeds, Wuding chickens (WDs) Daweishan mini (MCs), were compared with Cobb broilers (CBs). characteristics these breeds found to differ from CB. In particular, crude fat (CF), inosine monophosphate content, amino acid (AA), total fatty (TFA) content WDs significantly higher...
Mesenchymal stem cells (MSCs) are a valuable in vitro model for investigating the bone toxicity of cadmium (Cd). Autophagy has been proposed to play pivotal role Cd-mediated toxicity. The FOXO family proteins important transcription factors that essential autophagy induction. This study investigated Cd-induced skeleton damage and its potential mechanism. We exposed MSCs different concentrations chloride (3.5, 7, 14 μM) 24 h. demonstrated Cd treatment increased autophagic flux, inhibition...
Cisplatin (DDP) is the first-line drug for treatment of gastric cancer (GC). However, DDP resistance common. Autophagy, which closely related to chemoresistance, a process resolving and recycling proteins damaged cellular organs. Additionally, O-6-methylguanine-DNA methyltransferase (MGMT) responsible alkylating resistance. relationship between autophagy MGMT in response GC still unknown. In present study, we determined that induced by decreases chemosensitivity cell lines. may have...
Aptamers which are promising and effective molecular probes, can deliver either fluorescent materials or radionuclides to tumors. This study aimed develop a novel both radionuclide dual-modality probe based on truncated aptamer evaluate its stability binding affinities in vitro. The JHIT2 with specifically HepG2 cells was previously generated by Cell-SELEX. Using mfold RNAstructure software predict the secondary structure folded middle random sequence truncate primer sequences at ends of...
Abstract Bronchopneumonia is the most common pneumonia in childhood. Therefore, we tested effects of Remimazolam presented and its possible mechanisms. Phillygenin increased survival rate, reduced W/D ratio, lung injury score, inhibited IL‐1β, IL‐6, TNF‐α, INF‐γ levels mice model bronchopneumonia. induced PDPK1 p‐AKT protein expressions, suppressed NLRP3 expression tissue model. In vitro model, also expression. inflammation inhibitor, PHT‐427 (100 mg/kg) ratio promoted bronchopneumonia by...