A5102962201- Vascular Malformations Diagnosis and Treatment
- Intracranial Aneurysms: Treatment and Complications
- Spinal Dysraphism and Malformations
- Glioma Diagnosis and Treatment
- Cerebrospinal fluid and hydrocephalus
- Musculoskeletal pain and rehabilitation
- Pain Management and Treatment
- Neurogenesis and neuroplasticity mechanisms
- Neuroscience and Neuropharmacology Research
- Teratomas and Epidermoid Cysts
- Radiomics and Machine Learning in Medical Imaging
- Meningioma and schwannoma management
- GABA and Rice Research
- Plant Genetic and Mutation Studies
- Signaling Pathways in Disease
- Liver Disease and Transplantation
- Genetics and Neurodevelopmental Disorders
- Sarcoma Diagnosis and Treatment
- Hernia repair and management
- Genetic and phenotypic traits in livestock
- Sarcoidosis and Beryllium Toxicity Research
- Advanced Biosensing Techniques and Applications
- Neurosurgical Procedures and Complications
- Cell Image Analysis Techniques
- Intraoperative Neuromonitoring and Anesthetic Effects
The University of Tokyo
2012-2024
University of Tokyo Hospital
2012-2020
RIKEN Nishina Center
2020
Tokyo Metropolitan Neurological Hospital
2009
Kameda Medical Center
2007
Osaka City University
2005
University of Tsukuba
1997-2004
Sanin Rosai Hospital
2000
Yokohama City University
1997
Fukuoka University
1987
Abstract Dendritic spine generation and elimination play an important role in learning memory, the dynamics of which have been examined within neocortex vivo . Spine turnover has also detected absence specific tasks, is frequently exaggerated animal models autistic spectrum disorder (ASD). The present study aimed to examine whether baseline rate was activity-dependent. This achieved using a microfluidic brain interface open-dura surgery, with goal abolishing neuronal Ca 2+ signaling visual...
Abstract Ependymomas encompass multiple clinically relevant tumor types based on localization and molecular profiles. Tumors of the methylation class “spinal ependymoma” (SP-EPN) represent most common intramedullary neoplasms in children adults. However, their developmental origin is ill-defined, data are scarce, potential heterogeneity within SP-EPN remains unexplored. The only known recurrent genetic events loss chromosome 22q NF2 mutations, but neither frequency these alterations nor...
Excitatory synapses are often formed at small protrusions of dendrite, called dendritic spines, in most projection neurons, and the spine-head volumes show strong correlations with synaptic connectivity. We examined dynamics spine volume adult mouse visual cortex using time-lapse <i>in vivo</i> two-photon imaging a resonant Galvano scanner. Contrary to expectations, we found that spines neocortex showed fluctuations similar degree as observed young hippocampal preparations, but there were...
✓ Perineural cysts have become a common incidental finding during lumbosacral magnetic resonance (MR) imaging. Only some of the symptomatic warrant treatment. The authors describe successful operative treatment patient with, to best their knowledge, largest perineural cyst reported date. A 29-year-old woman had been suffering from long-standing constipation and low-back pain. During an obstetric investigation for infertility, clinician discovered huge presacral cystic mass. Computed...
There is agreement that symptomatic sacral meningeal cysts with a check-valve mechanism and/or large representing space-occupying lesions should be treated surgically. This study investigated factors indicating need for surgical intervention and techniques mechanism.In ten patients presenting sciatica neurological deficits, myelography, computed tomography (CT) magnetic resonance imaging (MR imaging) detected mechanism. One patient had two primary cysts. Ten were type 2 one cyst was 1. Nine...
Cerebral presenilin‐1 protein (PS‐1) is normally composed of the amino‐terminal fragment (NTF) with M r 28 kDa and carboxy‐terminal (CTF) 18 kDa. We analyzed human PS‐1 in brains early‐onset familial Alzheimer's disease (FAD) without mutations to study whether mutated was abnormally metabolized. were found be cleaved into two fragments NTF CTF independently occurrence mutation brains. A small portion recently suffer another processing by caspase‐3, an apoptosis‐related cysteine protease. In...
Calcineurin is required for long-term depression and activity-dependent spine shrinkage, calcineurin mutations have been identified in patients with schizophrenia. Moreover, mice conditional knockout of B (CNB-KO) exhibit behavioral abnormalities suggestive Changes the dendritic spines these mice, however, not investigated. We therefore examined CNB-KO observed a significant reduction small an increase large prefrontal visual cortices. The effect on sizes was relatively moderate, possibly...
Abstract An 82‐year‐old woman with Turner syndrome and schizophrenia, her 46‐year‐old daughter schizophrenia are described. 45X/46XX chromosomal mosaicism was identified in the peripheral leukocytes of mother, who showed several dysmorphisms cavum septi pellucidum brain. She had a normal reproductive life‐span. The resembled mother terms schizophrenic symptoms, but she did not show any signs dysmorphism or abnormality. phenotype‐karyotype relationship genetic psychosis discussed.
Abstract One of the effective methods in plant breeding is mutation breeding. Recently new techniques has risen by using heavy ion beam irradiation. The local rice variety, Pare Bau was used to study effect for aromatic improvement. Dry seeds were irradiated at dose 10 Gy Argon ion. Selected mutants from M 2 planted on 3 generation check their stability growth performance and early flowering. Results show that one M3 mutant line showed significantly lower plants height larger percentage...
Abstract: Axial neck and back pain after cervical spinal surgery is a common postoperative complication can last for years. It sometimes refractory to conventional treatments such as pharmacotherapy cord stimulation (SCS). Peripheral nerve field (PNFS) was recently introduced an alternative treatment in the management of axial into occipital/craniofacial region trunk occipital neuralgia, post-herpetic low lumbar spine surgery. However, PNFS has not been applied pain. The patient suffered...
Hemangioblastomas are hypervascular lesions and hence their surgical management is challenging. In particular, if complete resection to be attained, all feeding draining vessels must occluded. Although most intramedullary spinal cord tumors treated utilizing a posterior approach, we describe an anterior strategy for of cervical hemangioblastoma.A 36-year-old female with hemangioblastoma located in the presented long-standing history motor weakness right upper extremity. Magnetic resonance...
脳底動脈先端部動脈瘤あるいは頸動脈輪近傍内頸動脈瘤の手術は, 内頸動脈を長い距離にわたって露出し, その可動性を高めることが重要である.硬膜外側頭葉先端経由法(extradural temporopolar approach;ETA法)はこの目的に適している.側頭葉先端部硬膜と海綿静脈洞外壁の間を剥離し側頭葉を硬膜外から後方に引くことにより, 硬膜外かつ海綿静脈洞外から内頸動脈をC4部近くまで露出でき可動性を得ることができる.高位あるいは大きな脳底動脈先端部動脈瘤および内頸動脈輪近傍動脈瘤に対して本法を用い, 内頸動脈の両側に広く浅い作業空間を確保でき, 容易にクリップできた.これに対し脳底動脈・上小脳動脈分岐部動脈瘤に対して, 通常のpterional approachで十分と考え手術した.しかし内頸動脈と動眼神経の間にわずかな空間しか得られず, 内頸動脈を直接牽引したところ断裂が生じた.断裂部を被覆し動脈瘤をクリップしたが, 内頸動脈狭窄をきたした.再開頭し被覆圧迫部をゆるめ狭窄を解除したが, 脳梗塞を生じた.ETA法を用いていたら,...
Spinal arteriovenous fistulas (AVFs) are vascular lesions that often pose significant surgical challenges. This is particularly true for those located close to the anterior spinal artery. Here, we analyzed options treating an perimedullary AVF (pAVFs).A 66-year-old male with right lower extremity weakness was diagnosed a dural at L1 level. It initially treated open surgery followed by CyberKnife radiosurgery another institution. Five years later, he presented persistent pAVF fistula now...
Abstract Ependymomas encompass multiple, clinically relevant tumor types based on localization, genetic alterations, and epigenetic transcriptomic profiles. Tumors belonging to the methylation class of spinal ependymoma (SP-EPN) represent most common intramedullary neoplasms in children adults. However, molecular data SP-EPN are scarce, clear treatment recommendations lacking. The only known recurrent events loss chromosome 22q NF2 mutations. Yet, it remains unclear whether with germline or...
Late-onset adverse body reactions after blood donation are a serious problem when considering the safety of donors. However, predicting these at office can be difficult because their pathophysiology is poorly understood. We non-invasively monitored cardiac output (CO) and stroke volume (SV) 72 donors during autologous using an AESCULON mini device. The original preoperative reaction scale (PADARS) was used to estimate severity post-donation reactions. relationship between total PADARS score...