A5079847437- Liver physiology and pathology
- Drug-Induced Hepatotoxicity and Protection
- Liver Disease Diagnosis and Treatment
- Chromatography in Natural Products
- Traditional Chinese Medicine Analysis
- RNA Interference and Gene Delivery
- Pharmacological Effects of Natural Compounds
- Plant-based Medicinal Research
- Nanoparticle-Based Drug Delivery
- Gold and Silver Nanoparticles Synthesis and Applications
- Traditional Chinese Medicine Studies
- Monoclonal and Polyclonal Antibodies Research
- Biosensors and Analytical Detection
- Natural Compounds in Disease Treatment
- Antimicrobial Peptides and Activities
- Graphene and Nanomaterials Applications
- Flavonoids in Medical Research
- Metabolomics and Mass Spectrometry Studies
- Liver Diseases and Immunity
- Analytical Chemistry and Chromatography
- Natural product bioactivities and synthesis
- Pharmacogenetics and Drug Metabolism
- Anesthesia and Sedative Agents
- Glycosylation and Glycoproteins Research
- Advanced biosensing and bioanalysis techniques
Shanghai Ninth People's Hospital
2016-2025
Shanghai Jiao Tong University
2016-2025
China Academy of Chinese Medical Sciences
2025
Xiyuan Hospital
2025
Jinan University
2023
Fudan University
2019-2020
East China University of Science and Technology
2019-2020
Shanghai Third People's Hospital
2010-2017
Suzhou Kowloon Hospital
2015
Second Military Medical University
2013
Exosomes (Exo) hold great promise as endogenous nanocarriers that can deliver biological information between cells. However, Exo are limited in terms of their abilities to target specific recipient cell types. We developed a strategy isolate exhibiting increased binding integrin αvβ3. Binding occurred through modified version disintegrin and metalloproteinase 15 (A15) expressed on exosomal membranes (A15-Exo), which facilitated co-delivery therapeutic quantities doxorubicin (Dox)...
Abstract Cell membrane- covered drug-delivery nanoplatforms have been garnering attention because of their enhanced bio-interfacing capabilities that originate from source cells. In this top-down technique, nanoparticles (NPs) are by various membrane coatings, including membranes specialized cells or hybrid combine the capacities different types cell membranes. Here, membrane-coated doxorubicin (Dox)-loaded poly(lactic-co-glycolic acid) (PLGA) NPs (DPLGA@[RAW-4T1] NPs) were fabricated fusing...
Lianhuaqingwen (LHQW) capsule, a herb medicine product, has been clinically proved to be effective in coronavirus disease 2019 (COVID-19) pneumonia treatment. However, human exposure LHQW components and their pharmacological effects remain largely unknown. Hence, this study aimed determine anti-COVID-19 activities. Analysis of component profiles plasma urine after repeated therapeutic dosing was conducted using combination HRMS an untargeted data-mining approach, leading detection 132...
Background: Liver fibrosis occurs due to chronic liver disease multiple pathophysiological causes. The main causes for this condition are alcohol abuse, nonalcoholic steatohepatitis, and infection hepatitis C virus. Currently, there is more information available about the molecular as well cellular mechanisms, which play a role in advancement of fibrosis. However, still no effective therapy against it. Purpose: In order find an treatment fibrosis, our study explored whether salvianolic acid...
The aim of this research is to investigate the potential neuro-protective effect kaempferol which with anti-oxidant, anti-inflammatory, and immune modulatory properties, understand on reducing cerebral ischemia reperfusion (I/R) injury in vivo. Male adult Sprague Dawley (SD) rats were pretreated for one week via gavage before I/R operation. We found that treatment can reduce infarct volume neurological score after I/R. Rats sacrificed 24 h reperfusion. observed improved arrangement,...
Abstract The combination of an immuno-metabolic adjuvant and immune checkpoint inhibitors holds great promise for effective suppression tumor growth invasion. In this study, a pH-responsive co-delivery platform was developed metformin (Met), known modulator, short interfering RNA (siRNA) targeting fibrinogen-like protein 1 mRNA (siFGL1), using hybrid biomimetic membrane (from macrophages cancer cells)-camouflaged poly (lactic- co -glycolic acid) nanoparticles. To improve the endo-lysosomal...
Tanshinol ameliorates CCl4-induced liver fibrosis in rats through the regulation of Nrf2/HO-1 and NF-kappaB/IkappaBα signaling pathway Rong Wang,* Jing Fuxing Song, Shengnan Li, Yongfang Yuan Department Pharmacy, Shanghai 9th People’s Hospital, Jiao Tong University School Medicine, Shanghai, China *These authors contributed equally to this work Abstract: Tanshinol, a water-soluble component isolated from Salvia miltiorrhiza Bunge, has variety biological activities involving anti-fibrotic...
Cell membrane chromatography (CMC) is an ideal method for screening potential active components acting on target cell membranes from a complex system, such as herbal medicines. But due to the decay and falling-off of membranes, CMC column suffers short life span low reproducibility. This has greatly limited application this model, especially when materials are hard obtain. To solve problem, novel type (3-aminopropyl)triethoxysilane (APTES)-decorated silica gel was employed. The decorated...
Cell membrane affinity chromatography has been widely applied in protein (MP)-targeted drug screening and interaction analysis. However, current methods, the MP sources are derived from cell lines or recombinant expression, which time-consuming for culture purification, also difficult to ensure purity consistent orientation of MPs chromatographic stationary phase. In this study, a novel situ synthesis (iSMAC) method was developed utilizing cell-free expression (CFE) covalent immobilized...
Background: Liver fibrosis is the consequence of diverse liver injuries and can eventually develop into cirrhosis. Ginkgo biloba extract (GBE) an from dried ginkgo leaves that has many pharmacological effects because its various ingredients been shown to be hepatoprotective. Purpose methods: Aimed investigate underlying protective mechanisms GBE on carbon tetrachloride (CCl 4 )-induced in rats. Male Sprague Dawley rats were randomly divided four groups: control group (C), model (M), low-dose...
Osteoporosis is a bone metabolic disease caused by the imbalance between osteoblasts and osteoclasts due to excess osteoclastogenesis, manifesting in decrease of density strength. Scutellariae Radix shows good anti-osteoporosis activity, but effective component still unclear. Cell membrane chromatography (CMC) biological affinity with immobilized on silica carrier as stationary phase. It can realize dynamical simulation interactions drugs receptors cell membrane, which suitable for screening...
Abstract Background Enzalutamide (Enz) has shown limited bioavailability via oral administration. Castration-resistant prostate cancer (CRPC) is frequent among patients receiving 18–24 months of androgen deprivation therapy. The nonsteroidal anti-androgen enzalutamide used in the treatment Therefore, we developed a multifunctional enzalutamide-loaded graphene oxide nanosystem (TP-GQDss/Enz) for CRPC intravenous treatment, with high drug loading efficiency. Methods Aminated quantum dots...
Accurate orientations and stable conformations of membrane receptor immobilization are particularly imperative for accurate drug screening ligand-protein affinity analysis. However, there remain challenges associated with (1) traditional recombination, purification, receptors, which time-consuming labor-intensive; (2) the on stationary phase not easily controlled. Herein, a novel one-step synthesis oriented-immobilization membrane-receptor chromatography (oSOMAC) method was developed to...
Gypenosides (GPS) have been used as traditional medicine for centuries with various pharmacological effects. However, its therapeutic effects were restricted owing to the poor lipid and water solubility low absorption. This study aimed develop nanostructured carriers (NLCs) containing a bile salt formulation (sodium glycocholate, SGC) GPS, evaluate potential of GPS-SGC-NLCs an oral delivery system.The preparation was investigated using single-factor test central composite design response...