A5055055688- Advanced Sensor and Energy Harvesting Materials
- MicroRNA in disease regulation
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Extracellular vesicles in disease
- Polymer composites and self-healing
- Dielectric materials and actuators
- Cancer Cells and Metastasis
- Polydiacetylene-based materials and applications
- Immunotherapy and Immune Responses
- Immune cells in cancer
- Urban Transport and Accessibility
- Cancer, Hypoxia, and Metabolism
- Hydrogels: synthesis, properties, applications
- Lung Cancer Research Studies
- Cancer Genomics and Diagnostics
- Reconstructive Surgery and Microvascular Techniques
- Cancer-related molecular mechanisms research
- Digital Media Forensic Detection
- Reconstructive Facial Surgery Techniques
- Natural Compounds in Disease Treatment
- Ferroptosis and cancer prognosis
- Advanced Photonic Communication Systems
- Conducting polymers and applications
Zhejiang Chinese Medical University
2025
Academy of Military Medical Sciences
2025
Beijing University of Technology
2021-2024
Tsinghua University
2022-2024
Southwest Minzu University
2021-2024
Affiliated Hospital of Nantong University
2024
Nantong University
2024
Philips (China)
2024
Henan Cancer Hospital
2022-2024
Zhengzhou University
2022-2024
Abstract Cell membrane- covered drug-delivery nanoplatforms have been garnering attention because of their enhanced bio-interfacing capabilities that originate from source cells. In this top-down technique, nanoparticles (NPs) are by various membrane coatings, including membranes specialized cells or hybrid combine the capacities different types cell membranes. Here, membrane-coated doxorubicin (Dox)-loaded poly(lactic-co-glycolic acid) (PLGA) NPs (DPLGA@[RAW-4T1] NPs) were fabricated fusing...
Platinum-based anticancer drugs such as cisplatin, oxaliplatin, and carboplatin are some of the most potent chemotherapeutic agents but have limited applications due to severe dose-limiting side effects a tendency for cancer cells rapidly develop resistance. The therapeutic index can be improved through use nanocarrier systems target efficiently. We developed unique strategy deliver platinum(IV) drug prostate by constructing glutathione-stabilized (Au@GSH) gold nanoparticles. Glutathione...
The cancer stem cell (CSC) theory is gaining increasing attention from researchers and has become an important focus of research. According to the theory, a minority population cells capable self-renewal generation differentiated progeny, termed (CSCs). Understanding properties characteristics CSCs key future study on research, such as isolation identification CSCs, diagnosis, therapy. Standard oncology treatments, chemotherapy, radiotherapy surgical resection, can only shrink bulk tumor...
Abstract There are no non-hormonal male contraceptives currently on the market despite decades of efforts toward development “male pills”. Here, we report that triptonide, a natural compound purified from Chinese herb Tripterygium Wilfordii Hook F displays reversible contraceptive effects in both mice and monkeys. Single daily oral doses triptonide induces deformed sperm with minimal or forward motility (close to 100% penetrance) consequently infertility 3–4 5–6 weeks cynomolgus monkeys,...
Delivered: A solid lipid nanoparticle (SLN) system was developed to deliver microRNA-34a (miR-34a) relevant for cancer stem cell (CSC) therapy into lung tissues. In miR-34a-containing SLNs (miSLNs-34a), miR-34a is protected from degradation in the serum and its cellular-transfection efficiency vitro increased. Thus, treatment with miSLNs-34a results a higher probability of survival CSC-bearing mice (see picture). As service our authors readers, this journal provides supporting information...
Cancer-associated fibroblasts (CAFs) have been described to play critical roles in initiation, progression and metastasis of various cancers. However, the involvement CAFs oral cancer (OC) has not well addressed. In this study, we demonstrate that CAFs, when cocultured with OC cells (OCCs), produce high levels chemokine (C-C motif) ligand 2 (CCL2) and, subsequently, enhance endogenous reactive oxygen species production cells. Oxidative stress stimulates expression cell cycle proteins OCCs,...
Smart dielectric materials with bioinspired and autonomous functions are expected to be designed fabricated for next-generation electrical insulation. Similar organisms, such dielectrics self-adaptive, self-reporting, self-healing capabilities can employed avoid, diagnose, repair damage prevent catastrophic failure even a blackout. Compared traditional dielectrics, the utilization of smart not only increases stability durability power apparatus but also reduces costs production...
Abstract Helicobacter pylori infection is strongly associated with chronic gastritis, peptic ulcers, and gastric cancer. Antibiotic resistance in H. an increasingly serious threat to global public health. Although oral vaccination considered be a promising strategy for protection against infection, the poor efficacy of vaccines remains major challenge due their ability penetrate mucus cross transepithelial absorption barriers. This study reports development well‐designed nanoparticle that...
In addition to early detection, diagnosis, and surgery, it is of great significance use new strategies for the treatment hepatocellular carcinoma (HCC). Studies showed that combination sorafenib (SFN) triptolide (TPL) could reduce clinical dose SFN maintain good anti-HCC effect. But solubility TPL in water low both drugs have certain toxicity. Therefore, we constructed a biomimetic nanosystem based on cancer cell-platelet (PLT) hybrid membrane camouflage co-deliver taking advantage PLT with...
Dielectric polymers are playing important roles in electrical and electronic industries. However, aging under high electric stress is a main threat to the reliability of polymers. In this work, we demonstrate self-healing method for tree damage based on radical chain polymerization, which initiated by situ radicals that generated during aging. Acrylate monomers contained microcapsules will be released flow into hollow channels after capsules punctured trees. Autonomous polymerization heal...
Objective: The objective of this study was to investigate the causal relationship between number lifetime sexual partners (NLSP) and cervical cancer (CC) using Mendelian randomization (MR) method. Methods: Genome-wide association (GWAS) data on NLSP CC were obtained from integrative epidemiology unit open genome-wide studies (IEU OpenGWAS) project. To assess correlation risk, we employed inverse-variance weighted (IVW) method, applying a preset threshold select single nucleotide...
Drug-target interaction prediction is critical for drug development. Through the integration of structural and transcriptional signature information, molecules both binding to target inducing therapeutic activities could be found out improve targeted prediction. Therefore, approaches that integrate two types data are worth exploring. Here, we present an integrated method named Data Integration Oriented Repurposing Strategy (DIORS) combining molecular docking gene-signature matching enhance...
The integration of neural networks with perturbation theory has been recognized as a pivotal factor contributing to the enhancement transmission efficiency in modern optical communication systems. Research focuses on balancing superior equalization performance against system complexity minimization. This paper presents novel and efficient data dimensionality reduction compression methodology for developing low-complexity network-based equalizers intended mitigate nonlinear impairments fiber...
Elongation Factor Tu GTP Binding Domain Containing 2 (EFTUD2), a conserved spliceosomal GTPase, is involved in craniofacial development and various cancers, but its role lung adenocarcinoma (LUAD) remains unclear. EFTUD2 expression LUAD tissues was analyzed using data from TCGA GEO, validated by immunohistochemistry, RT-qPCR, Western blotting. The relationship between clinical features examined Fisher's exact test. Diagnostic prognostic analyses were performed R. Hub genes related to...
Network traffic includes data transmitted across a network, such as web browsing and file transfers, is organized into packets (small units of data) flows (sequences exchanged between two endpoints). Classifying encrypted essential for detecting security threats optimizing network management. Recent advancements have highlighted the superiority foundation models in this task, particularly their ability to leverage large amounts unlabeled demonstrate strong generalization unseen data....