A5101808215- Organ Transplantation Techniques and Outcomes
- Anesthesia and Neurotoxicity Research
- Liver Disease and Transplantation
- Anesthesia and Sedative Agents
- MicroRNA in disease regulation
- Cardiac Ischemia and Reperfusion
- Neuroinflammation and Neurodegeneration Mechanisms
- Cardiac, Anesthesia and Surgical Outcomes
- Liver physiology and pathology
- Respiratory Support and Mechanisms
- Anesthesia and Pain Management
- Pediatric Hepatobiliary Diseases and Treatments
- Circular RNAs in diseases
- Neuroblastoma Research and Treatments
- RNA Interference and Gene Delivery
- Pain Mechanisms and Treatments
- Liver Disease Diagnosis and Treatment
- Tracheal and airway disorders
- Airway Management and Intubation Techniques
- Immune Response and Inflammation
- Drug Transport and Resistance Mechanisms
- Health and Medical Research Impacts
- Neuroscience and Neuropharmacology Research
- Epilepsy research and treatment
- Traumatic Brain Injury and Neurovascular Disturbances
Renji Hospital
2016-2025
Shanghai Jiao Tong University
2016-2025
Southwest University
2014-2025
Peking University
2025
Shenzhen Bay Laboratory
2025
Sun Yat-sen University
2023
State Key Laboratory of Oncogene and Related Genes
2021
Beijing University of Technology
2021
Ministry of Agriculture and Rural Affairs
2020
State Key Laboratory of Silkworm Genomic Biology
2014-2019
Abstract The ability to regulate membrane protein abundance offers great opportunities for developing therapeutic sites various diseases. Herein, we describe a platform the targeted degradation of membrane‐associated proteins using bispecific aptamer chimeras that bind both cell‐surface lysosome‐shuttling receptor (IGFIIR) and membrane‐bound interest. We demonstrate can efficiently quickly shuttle therapeutically relevant Met PTK‐7 lysosomes degrade them through lysosomal machinery....
Abstract Background and Aims Lackluster results from recently completed gene therapy clinical trials of VEGF-A delivered by viral vectors have heightened the need to develop alternative delivery strategies. This study aims demonstrate pre-clinical efficacy safety extracellular vesicles (EVs) loaded with mRNA for treatment ischaemic vascular disease. Methods After encapsulation full-length into fibroblast-derived EVs via cellular nanoporation (CNP), collected were mouse models injury. Target...
In Brief Study Design. Post-traumatic inflammatory response was studied in 11 human cases of acute spinal cord contusion injury. Objectives. To examine the cellular and immunocytochemical expression localization interleukin-1β, internleukin-6, tumor necrosis factor-αin after Summary Background Data. The post-traumatic plays an important role secondary injury mechanisms injury, inter-leukin-1β, factor-α are key mediators. Methods. study group comprised patients with 2 normal individuals....
With the emergence of novel technologies and ground breaking concepts in BBB basic research past decades, researchers’ attention on critical role blood brain barrier (BBB) integrity after stroke is surging. The main novelty this review that it not only highlights recent findings signaling pathways mediating ischemic disruption, such as vascular permeability, lactate transportation failure, mitochondrial crisis ion channel water disability, endothelial actin polymerization, junctional...
<h3>Background and aims</h3> Reg4 is a recently discovered member of the regenerating gene family with distinctive expression profiles in primary cancers. To date, physiological function poorly understood. Previously, authors found that was markedly upregulated during acute pancreatitis (AP). The aim this study to investigate role experimental pancreatitis. <h3>Methods</h3> AP induced C57BL/6 mice by administration either l-arginine or caerulein, assessed immunofluorescence, reverse...
In Brief Objective: This study aimed to evaluate the perioperative and long-term results of partial hepatectomy for patients with complicated bilateral primary hepatolithiasis. Summary Background Data: Hepatolithiasis is best managed by a multidisciplinary approach. Definitive treatment can be offered using endoscopic, percutaneous, laparoscopic, or open surgical approaches. Partial only indicated recurrent, troublesome, localized, severe disease affecting liver. Methods: From January 2000...
Despite the implementation of various postoperative management strategies, prevalence fatigue syndrome (POFS) remains considerable among individuals undergoing laparoscopic radical gastrectomy. While N-methyl-D-aspartic acid receptor antagonist esketamine has demonstrated efficacy in enhancing sleep quality and alleviating pain, its impact on POFS uncertain. Consequently, objective this study is to ascertain whether perioperative administration can effectively mitigate occurrence patients
Opioid preconditioning against ischemia reperfusion injury has been well studied in myocardial and neuronal tissues. The objective of this study was to determine whether remifentanil could attenuate hepatic investigate the mechanisms.A rat model a hepatocyte hypoxia reoxygenation (HR) were used, respectively, two series experiments. Remifentanil administered before or experiments repeated with previous administration naloxone, L-arginine N-ω-nitro-L-arginine methyl ester, nonselective opioid...
High-risk neuroblastoma remains one of the deadliest childhood cancers. Identification metabolic pathways that drive or maintain high-risk may open new avenues therapeutic interventions. Here, we report isolation and propagation sphere-forming cells with self-renewal differentiation potential from tumors TH-MYCN mouse, an animal model MYCN amplification. Transcriptional profiling reveals mouse acquire a program characterized by transcriptional activation cholesterol serine-glycine synthesis...
Abstract MEIS2 has an important role in development and organogenesis, is implicated the pathogenesis of human cancer. The molecular basis action tumorigenesis not clear. Here, we show that highly expressed neuroblastoma cell lines required for survival proliferation. Depletion cells leads to M-phase arrest mitotic catastrophe, whereas ectopic expression markedly enhances proliferation, anchorage-independent growth, tumorigenicity. Gene profiling reveals essential maintaining a large number...
Backgroud:Glioblastoma is a kind of highly malignant and aggressive tumours in the central nervous system. Previously, we found that neurotensin (NTS) its high-affinity receptor 1 (NTSR1) had essential roles cell proliferation invasiveness glioblastoma. Unexpectedly, death also appeared by inhibition NTSR1 except for cycle arrest. However, mechanisms were remained to be further explored.Cells treated with SR48692, selective antagonist NTSR1, or shRNA stained Annexin V-FITC/PI apoptosis was...
Abstract Background The nuclear protein high-mobility group box 1 (HMGB1) is a key trigger for the inflammatory reaction during liver ischemia reperfusion injury (IRI). Hydrogen treatment was recently associated with down-regulation of expression HMGB1 and pro-inflammatory cytokines sepsis myocardial IRI, but it not known whether hydrogen has an effect on in IRI. Methods A rat model 60 minutes 70% partial used. enriched saline (2.5, 5 or 10 ml/kg) injected intraperitoneally before hepatic...
The utilization of local anesthetics for postoperative analgesia represents an effective approach, but generally suffers from short half-lives and brachychronic neurotoxicity. A desirable anesthetic with controllable sustainable drug-releasing performance adequate effect is highly required. In this work, the core/shell-structured two-dimenional (2D) silicene nanosheets coated mesoporous silica layer (abbreviated as Silicene@MSNs) have been rationally constructed localized drug-delivery...
Background: This study aimed to explore the influence of endothelial cell-specific molecule 1 (ESM1) expression on colorectal cancer (CRC) cells and preliminarily analyze its possible mechanism, so as lay a foundation for research about potential biological targets CRC. Methods: First, CRC were transfected with ESM1-negative control (NC), ESM1-mimic ESM1-inhibitor randomly assigned ESM1-NC group, group respectively. Then harvested at 48 h after transfection subsequent experiments. Results:...
Summary The two most commonly used airway management techniques during general anaesthesia are supraglottic devices and tracheal tubes. In older patients undergoing elective non‐cardiothoracic surgery under with positive pressure ventilation, we hypothesised that a composite measure of in‐hospital postoperative pulmonary complications would be less frequent when device was compared tube. We studied aged ≥ 70 years in 17 clinical centres. Patients were allocated randomly to or Between August...
AIM:To determine whether parenchymal cells or hepatic cytochrome P450 protein was changed in chronic liver diseases, and to compare the difference of CYP3A4 enzyme its gene expression between patients with cirrhosis obstructive jaundice, investigate pharmacologic significance behind this difference. METHODS:Liver samples were obtained from undergoing surgery (n=6) jaundice angeioma (controls, n=6).CYP3A4 activity determined by Nash western bloting using specific polychonal antibody,...
Background Reactive oxygen and nitrogen species are key molecules that mediate neuropathic pain. Although hydrogen is an established antioxidant, its effect on chronic pain has not been characterized. This study was to investigate the efficacy mechanisms of hydrogen-rich normal saline induced analgesia. Methodology/Principal findings In a rat model by L5 spinal nerve ligation (L5 SNL), intrathecal injection relieved SNL-induced mechanical allodynia thermal hyperalgesia. Importantly, repeated...
Summary Aims Demyelination, one of the major pathological changes white matter injury, is closely related to T‐cell–mediated immune responses. Thus, we investigate role an IL‐2 monoclonal antibody (IL‐2mAb, JES6‐1) in combatting demyelination during late phase stroke. Methods IL‐2mAb or IgG isotype (0.25 mg/kg) was injected intraperitoneally 2 and 48 hours after middle cerebral artery occlusion (MCAO) surgery. Infarct volume, peripheral cell infiltration, microglia activation, myelin loss...