A5024959130- Natural product bioactivities and synthesis
- Bioactive natural compounds
- Phytochemistry and Biological Activities
- Natural Antidiabetic Agents Studies
- Esophageal Cancer Research and Treatment
- Cancer-related molecular mechanisms research
- Traditional Chinese Medicine Analysis
- Traditional and Medicinal Uses of Annonaceae
- Biochemical Analysis and Sensing Techniques
- Esophageal and GI Pathology
- melanin and skin pigmentation
- RNA modifications and cancer
- Chromatography in Natural Products
- Phytochemicals and Antioxidant Activities
- Synthesis of Organic Compounds
- Medicinal Plant Pharmacodynamics Research
- Analytical Chemistry and Sensors
- Biological Activity of Diterpenoids and Biflavonoids
- Bioactive Natural Diterpenoids Research
- Inflammatory Biomarkers in Disease Prognosis
- Alkaloids: synthesis and pharmacology
- Circular RNAs in diseases
- Multiple Myeloma Research and Treatments
- Tryptophan and brain disorders
- Bioactive Compounds and Antitumor Agents
Shanghai Institute of Pharmaceutical Industry
2016-2024
Guangzhou Medical University
2019-2023
Guangzhou Medical University Cancer Hospital
2022
Sun Yat-sen University
2018
Sun Yat-sen University Cancer Center
2018
Southern Medical University
2013-2015
Zhujiang Hospital
2015
Changhua Christian Hospital
2008
Argonne National Laboratory
1980-1982
University of Chicago
1981-1982
Abstract Radiotherapy is one of the standard treatments for glioma patients; however, its clinical efficacy limited by radioresistance. We identified a mechanism such resistance mediated linc-RA1 (radioresistance-associated long intergenic noncoding RNA 1). Linc-RA1 was upregulated in radioresistant cells and tissue samples, compared with radiosensitive nontumor tissues. associated inferior overall survival advanced stage . promoted radioresistance vitro vivo. Mechanistically, stabilized...
The systemic inflammation score (SIS), based on serum albumin (Alb) and lymphocyte-to-monocyte ratio (LMR), is a novel prognostic tool for some tumours. Studies indicate that the SIS can be used as postoperative marker. However, its predictive value in elderly oesophageal squamous cell carcinoma (ESCC) patients treated with radiotherapy unclear.In total, 166 ESCC who received or without chemotherapy were included. Based different combinations of Alb LMR levels, was divided into 3 groups, = 0...
N-acetylglucosaminyltransferase V (Gnt-V) has been linked to the migration of various human cancers. Recently we have found that inhibition Gnt-V increases radiosensitivity cancer cells. However, mechanisms by which mediates and migration, especially in small cell lung (SCLC) remain unknown. In our study, two SCLC lines (H1688 H146) were used investigate whether modulated cells through epithelial-mesenchymal transition (EMT). The results showed expression correlated with N stage patients...
Abstract Three new Diels-Alder adducts, macrourins E – G (1–3), one 2-arylbenzofuran, macrourin H (4), and eight known adducts (5–12) were isolated from Morus macroura. Their structures elucidated through extensive analysis of spectroscopic data. The 1H NMR ECD trends in the determination configurations these summarized. tyrosinase inhibitory activities all compounds evaluated, (1–4) as well found to be potent with IC50 values ranging 0.39 4.54 µM. Among them, 1 showed best activity an value...
A novel benzofuranone unprecedentedly with a prenyl group at C-3, nigranol (1), new flavonol, B (2), and three known compounds, sanggenon M (3), nigrasin C (4), (5) were isolated from the twigs of Morus nigra Linn. Their structures elucidated on basis analysis multiple spectroscopic data. All along eight previously ones (6-13) investigated for their α-glucosidase inhibitory activities. The result showed that compounds 1-13 except 4 exhibited prominent activities against α-glucosidase. Among...
Abstract The incidence of elderly patients with esophageal cancer (OC) is increasing as the population ages. Until now, treatment strategy in these has been unclear. aim our study was to assess efficiency and tolerance radiotherapy alone (RT alone), single‐agent‐based concurrent chemoradiotherapy (CCRT‐1), or double‐agent‐based (CCRT‐2) (≥65 years) OC. A total 271 OC aged 65 years older were included this study. median overall survival (OS), progression‐free (PFS), response rate (ORR),...
Although hexokinase (HK) 2, pyruvate kinase muscle (PKM) isozyme 2 and lactate dehydrogenase (LDH) A predict the efficacy of medicines in various solid tumors, their ability to cetuximab metastatic colorectal cancer (mCRC) remains unclear. mCRC patients with pathological specimens who received chemotherapy from 2005 2015 present institution were enrolled. Immunohistochemistry was used detect HK2, PKM2 LDHA expression. SPSS20 for statistical analysis. total 68 included; 33 plus as first-line...
Despite improvements in nasopharyngeal carcinoma (NPC) treatment, patients with recurrence and metastasis still have a poor prognosis. Thus, the identification of novel biomarkers is urgently needed to predict outcomes tailor treatment for NPC.Four data sets were downloaded from Gene Expression Omnibus, one set GSE68799 which was applied filtrate key modules hub genes by construction co-expression network. Other (GSE12452 GSE53819) used verify genes. The GSE102349 devoted identify prognostic...
Elderly patients with esophageal carcinoma may benefit from concurrent chemoradiotherapy (CCRT). However, the optimal chemotherapy regimen has not been determined. The aim of our study was to assess efficiency and tolerance treatment a 5-fluorouracil (5-Fu)–based taxane-based combined radiotherapy in elderly squamous cell (ESCC). A total 46 ESCC aged older than 65 years were included this study. patient population divided into two groups: 24 who received CCRT 5-Fu–based allocated PF group,...
The study is to establish the two-dimension HPLC fingerprints of Dihuang (Rehmannia glutinosa), by HPLC-PDA and HPLC-ELSD methods. separations were performed on Waters Atlantis®T3（4.6 mm× 250 mm，5 μm）and Welch Ultimate®Hilic-NH₂（4.6 μm）columns with gradient elution acetonitrile-0.01% phosphoric acid acetonitrile-water, respectively. chromatographic display wavelength for PDA detector was set at 203 nm. For HPLC-ELSD, nebulizer as cooling mode, drift tube temperature 60 °C gas pressure 35.0...
Two new phenolic compounds, 2-(2-hydroxyphenyl)-4-methoxycarbonyl-5-hydroxybenzofuran (1) and 1-methoxycarbonyl-2, 3-dihydroxydibenzo[b, f]oxepine (2), were isolated from the tuber of Sparganium stoloniferum. The structures both compounds determined on basis spectroscopic means including HR-ESI-MS, 1D 2D NMR experiments.
Traditional Chinese medicine formula (TCMF) Run-zao-zhi-yang capsule (RZZY) is commonly used in treating itch China. However, there are few studies on its mechanisms. In this study, we revealed the mechanisms and molecular targets of RZZY for by network pharmacology, docking, vitro experiments.The pharmacology consisted active ingredient collection, target acquisition, enrichment analysis, biological process construction. Molecular docking was carried out using molegro virtual docker (MVD)...