A5004908576- Advanced biosensing and bioanalysis techniques
- Biosensors and Analytical Detection
- Aquaculture disease management and microbiota
- Immune Cell Function and Interaction
- Pharmacological Effects and Assays
- Advanced Nanomaterials in Catalysis
- Bone Tissue Engineering Materials
- Electrochemical sensors and biosensors
- Immune cells in cancer
- T-cell and B-cell Immunology
- Photosynthetic Processes and Mechanisms
- Aquaculture Nutrition and Growth
- Electrospun Nanofibers in Biomedical Applications
- Wound Healing and Treatments
- Pharmaceutical and Antibiotic Environmental Impacts
- Mass Spectrometry Techniques and Applications
- Environmental Toxicology and Ecotoxicology
- Aquatic Ecosystems and Phytoplankton Dynamics
- Antimicrobial Peptides and Activities
- Pesticide Residue Analysis and Safety
- HIV Research and Treatment
- Immune Response and Inflammation
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Electrochemical Analysis and Applications
Fudan University
2020-2025
Shanghai Stomatological Hospital
2025
Soochow University
2015-2024
First Affiliated Hospital of Soochow University
2010-2024
Jiaxing University
2024
Wenzhou Medical University
2024
Capital Medical University
2024
Sichuan University
2023
Shenzhen University
2021-2022
Guangzhou Institutes of Biomedicine and Health
2019-2022
T lymphocyte dysfunction contributes to human immunodeficiency virus type 1 (HIV-1) disease progression by impairing antivirus cellular immunity. However, the mechanisms of HIV-1 infection-mediated cell are not completely understood. Here, we provide evidence that expansion monocytic myeloid-derived suppressor cells (M-MDSCs) suppressed function in HIV-1-infected individuals. We observed a dramatic elevation M-MDSCs (HLA-DR(-/low) CD11b(+) CD33(+/high) CD14(+) CD15(-) cells) peripheral blood...
Hepatocellular carcinoma (HCC) is the fifth most common malignancy caused by environmental and genetic factors. MicroRNAs (miRNAs) are a class of short non-coding RNAs with posttranscriptional regulatory functions. They participate in diverse biological pathways function as gene regulators. Genetic polymorphisms 3′ untranslated regions (3′ UTRs) targeted miRNAs alter strength miRNA binding, consequences on regulation target genes thereby affecting individual's cancer risk. We have previously...
The TATA box represents one of the most prevalent core promoters where pre-initiation complexes (PICs) for gene transcription are assembled. This assembly is crucial initiation and well regulated. Here we show that some cellular microRNAs (miRNAs) associated with RNA polymerase II (Pol II) box-binding protein (TBP) in human peripheral blood mononuclear cells (PBMCs). Among them, let-7i sequence specifically binds to TATA-box motif interleukin-2 (IL-2) elevates IL-2 mRNA production CD4(+)...
PIWI interacting RNAs (piRNAs) are highly expressed in germline cells and involved maintaining genome integrity by silencing transposons. These also DNA/histone methylation gene expression regulation somatic of invertebrates. The functions piRNAs vertebrates, however, remain elusive. We found that snoRNA-derived C (C′)/D′ (D)-box conserved abundant human CD4 primary T-lymphocytes. piRNA (piR30840) significantly downregulated interleukin-4 (IL-4) via sequence complementarity binding to...
PIWI-interacting RNA (piRNA) silences the transposons in germlines or induces epigenetic modifications invertebrates. However, its function mammalian somatic cells remains unknown. Here we demonstrate that a piRNA derived from Growth Arrest Specific 5, tumor-suppressive long non-coding RNA, potently upregulates transcription of tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), proapoptotic protein, by inducing H3K4 methylation/H3K27 demethylation. Interestingly, PIWIL1/4...
Abstract While rapid wound healing is essential yet challenging, there also an unmet need for functional restoration of sensation. Inspired by natural skin, ultra‐conformable, adhesive multi‐functional ionic skin (MiS) with multi‐modal sensing capability devised smart and expedited care. The base MiS a unique skin‐like, conductive self‐adaptive polyacrylamide/starch double‐network hydrogel (PSH) self‐powered, flexible, triboelectric sensor(s) integrated on top PSH multi‐tactile sensing....
Background Atherosclerosis and cardiovascular diseases are significantly affected by low-grade chronic inflammation. As a new inflammatory marker, the systemic inflammation response index (SIRI) has been demonstrated to be associated with several disease prognoses. This study aimed investigate prognostic impact of SIRI in individuals having ischemic heart failure (IHF) following percutaneous coronary intervention (PCI). Methods observational, retrospective cohort was conducted at single...
Aflatoxins (AFs) including AFB1, AFB2, AFG1 and AFG2 are widely found in agriculture products, AFB1 is considered one of the most toxic harmful mycotoxins. Herein, a highly sensitive (at pg mL−1 level) group-specific enzyme-linked immunosorbent assay (ELISA) for detection agricultural aquiculture products was developed. The derivative containing carboxylic group synthesized covalently linked to bovine serum albumin (BSA). AFB1-BSA conjugate used as an immunogen immunize mice. A high-quality...
Abstract Inflammation is a protective response that implicated in bacterial enteritis and other fish diseases. The inflammatory mechanisms behind Aeromonas hydrophila infections remain poorly understood. In this study, we performed de novo grass carp transcriptome assembly using Illumina’s Solexa sequencing technique. On basis carried out comparative analysis of intestinal transcriptomes from A. -challenged physiological saline solution (PSS/mock) fish, 315 genes were up-regulated 234...
Abstract Maternal immune system tolerance to the semiallogeneic fetus is essential for a successful pregnancy; however, mechanisms underlying this immunotolerance have not been fully elucidated. Here, we demonstrate that myeloid-derived suppressor cells play an important role in maintaining feto-maternal tolerance. A significant expansion of granulocytic was observed multiple organs and decidual tissues from pregnant mice. Pregnancy-derived suppressed T cell responses reactive oxygen...
Sr-CPHC is a starch-reinforced calcium phosphate cement with SrCO<sub>3</sub> incorporation, exhibiting synergistic effect of osteogenesis and angiogenesis, which showed remarkable in rat calvarial defect repair.
Mg-based alloys as revolutionary implantable biomaterials have increasingly attracted considerable attention, owing to their biodegradability in vivo and beneficial effects on biological systems. The degradation process products of been reported exhibit significant host-tissue responses. However, these not yet fully understood. This review systemically summarizes analyses the current understandings recent research progress this area. primary focal points are related mechanisms associated...
l-Arginine and l-arginine-metabolizing enzymes play important roles in the biology of some types myeloid cells, including macrophage myeloid-derived suppressor cells. In this study, we found evidence that arginase 1 (Arg1) is required for differentiation mouse dendritic cells (DCs). Expression Arg1 was robustly induced during monocyte-derived DC differentiation. Ectopic expression significantly promoted monocytic a granulocyte-macrophage colony-stimulating factor culture system also...