A5001918918- Tissue Engineering and Regenerative Medicine
- Immune Cell Function and Interaction
- Mesenchymal stem cell research
- MicroRNA in disease regulation
- Immunotherapy and Immune Responses
- Autophagy in Disease and Therapy
- Cardiac Fibrosis and Remodeling
- Complement system in diseases
- Electrospun Nanofibers in Biomedical Applications
- Atherosclerosis and Cardiovascular Diseases
- Cancer-related molecular mechanisms research
- Genomics and Rare Diseases
- Genomic variations and chromosomal abnormalities
- Cancer, Hypoxia, and Metabolism
- Aortic Disease and Treatment Approaches
- Genetic Associations and Epidemiology
- Phagocytosis and Immune Regulation
- Mitochondrial Function and Pathology
- Hemoglobinopathies and Related Disorders
- Circular RNAs in diseases
- Migraine and Headache Studies
- T-cell and B-cell Immunology
- Ubiquitin and proteasome pathways
- Congenital heart defects research
- Cardiomyopathy and Myosin Studies
China-Japan Friendship Hospital
2012-2025
Sichuan University
2016-2024
Duke University
2002-2024
Beike Biotechnology (China)
2024
West China Hospital of Sichuan University
2016-2024
Beijing Tongren Hospital
2007-2024
Capital Medical University
2007-2024
The University of Tokyo
2020-2024
Shenyang Pharmaceutical University
2024
Fujian Polytechnic of Information Technology
2024
Macroautophagy plays an important role in the regulation of cell survival, metabolism, and lysosomal degradation cytoplasmic material. In immune system, autophagy contributes to clearance intracellular pathogens, MHCII cross-presentation endogenous Ags, as well survival. We others have demonstrated that occurs T lymphocytes their cellular function, including survival proliferation. Here we show essential gene Atg7 is required a cell-intrinsic manner for mature primary lymphocytes. also find...
FOXO1A and FOXO3A are two members of the FoxO family. has recently been linked to human longevity in Japanese, German Italian populations. Here we tested genetic contribution phenotype Han Chinese population. Six tagging SNPs from were selected genotyped 1817 centenarians younger individuals. Two found be associated with women (P = 0.01–0.005), whereas all three both genders 0.005–0.001). One SNP was not longevity. In haplotype association tests, OR (95% CI) for haplotypes TTG CCG female...
Cells internalize soluble ligands through endocytosis and large particles actin-based phagocytosis. The dynamin family of GTPases mediates the scission endocytic vesicles from plasma membrane. We report here that 2, a ubiquitously expressed isoform, has role in phagocytosis macrophages. Dynamin 2 is enriched on early phagosomes, expression dominant-negative mutant significantly inhibits particle internalization at stage membrane extension around particle. This arrest resembles seen with...
Although mesenchymal stem cell (MSC) transplantation has been shown to promote cardiac repair in acute myocardial injury vivo, its overall restorative capacity appears be restricted mainly because of poor viability and low engraftment the ischemic myocardium. Specific chemokines are upregulated infarcted However expression levels corresponding chemokine receptors (eg, CCR1, CXCR2) MSCs very low. We hypothesized that this discordance may account for MSC survival.To determine whether...
Pancreatic cancer is characterized by stromal desmoplasia and perineural invasion (PNI). We sought to explore the contribution of pancreatic stellate cells (PSC) activated paracrine Sonic Hedgehog (SHH) in PNI progression.In this study, expression dynamics SHH were examined via immunohistochemistry, real-time PCR, Western blot analysis a cohort carcinomatous nonneoplastic tissues cells. A series vivo vitro assays was performed elucidate PSCs signaling progression.We show that overexpression...
In contrast to its inhibitory effects on many cells, IL10 activates CD8(+) tumor-infiltrating lymphocytes (TIL) and enhances their antitumor activity. However, TILs do not routinely express IL10, as autocrine complement C3 inhibits production through receptors C3aR C5aR. from C3-deficient mice, however, exhibit enhanced effector function. mice are resistant tumor development in a T-cell- IL10-dependent manner; human expanded with IL2 plus increase the killing of primary tumors vitro compared...
Endothelial dysfunction is an important determinant risk factor for the development of hypertension and its complications. Thus, identification potential therapeutic targets preventing endothelial has major clinical importance. Emerging evidence indicates that epigenetic modifications are closely associated with regulation function. Among them, HDAC (histone deacetylase)-mediated processes in vascular homeostasis cardiovascular disease have attracted much attention. SIRT6 (sirtuin 6) one...
The highly conserved cellular degradation pathway, macroautophagy, regulates the homeostasis of organelles and promotes survival T lymphocytes. Previous results indicate that Atg3-, Atg5-, or Pik3c3/Vps34-deficient cells cannot proliferate efficiently. Here we demonstrate proliferation Atg7-deficient is defective. By using an adoptive transfer Listeria monocytogenes (LM) mouse infection model, found primary immune response against LM intrinsically impaired in autophagy-deficient CD8(+)...
The elimination of cancer cells critically depends on the immune system. However, cancers have evolved a variety defense mechanisms to evade monitoring, leading tumor progression. Complement factor H (CFH), predominately known for its function in inhibiting alternative pathway complement system, has recently been identified as an important innate immunological checkpoint cancer. CFH-mediated immunosuppression enhances cells’ ability avoid recognition and produce immunosuppressive...
Ultrasound-targeted microbubble destruction (UTMD) uses ultrasound energy to selectively deliver genes into the myocardium using plasmids conjugated microbubbles. We hypothesized that repeated delivery of stem cell-mobilizing could boost ability this therapy enhance cardiac repair and ventricular function after a myocardial infarction.Beginning 7 days coronary artery ligation, cell factor (SCF) stromal cell-derived (SDF)-1α were administered adult rats 1, 3, or 6 UTMD treatments (repeat...
Background— Allogeneic mesenchymal stem cells (MSCs) were immunoprivileged early after cardiac implantation and improved heart function in preclinical clinical studies. However, long-term studies demonstrated that allogeneic MSCs lost their immunoprivilege rejected the injured myocardium, resulting recurrent ventricular dysfunction. This study identifies some of mechanisms responsible for immune switch suggests a new treatment to maintain preserve function. Methods Results— Rat MSC was...
Abstract Histone deacetylase ( HDAC ) 9, a member of class II s, regulates wide variety normal and abnormal physiological functions, which is usually expressed at high levels in the brain skeletal muscle. Although studies have highlighted importance ‐mediated epigenetic processes development ischaemic stroke very recent genome‐wide association identified variant 9 associated with large‐vessel ischemic stroke, molecular events by induces cerebral injury keep unclear. In this study, we found...
Tumor-targeting Abs can be used to initiate an antitumor immune program, which appears essential achieve a long-term durable clinical response cancer. We previously identified anti-complement factor H (CFH) autoantibody associated with patients early-stage non-small cell lung cloned from their peripheral B cells mAb, GT103, that specifically recognizes CFH on tumor cells. Although the underlying mechanisms are not well defined, GT103 targets conformationally distinct epitope is created when...
To investigate the association of ABCG1, GALNT2 and HMGCR genes promoter DNA methylation with coronary heart disease (CHD) explore interaction between their status CHD patients' clinical characteristics in Han Chinese population.Methylation-specific polymerase chain reaction (MSP) technology was used to examine role aberrant gene population. A total 85 patients 54 participants without confirmed by angiography were recruited. 82.8% ABCG1 hypermethylation have CHD, while only 17.4% it. The...
Abstract Objectives Thalassemia is a highly prevalent monogenic inherited disease in southern China. It important to collect epidemiological data comprehensively for proper prevention and treatment. Methods In this study, blood samples collected from 15 807 residents of Chenzhou were primarily screened by hematological tests. A total 3973 suspected thalassemia carriers further characterized combined next‐generation sequencing (NGS) Gap‐PCR. Results total, 1704 subjects diagnosed as with...
Abstract Wnts comprise a family of 20 lipid-modified glycoproteins in mammals and play critical roles during embryological development organogenesis several organ systems, including the heart. They are required for mesoderm formation have been implicated promoting cardiomyogenic differentiation mammalian embryonic stem cells, but underlying mechanisms regulating Wnt signaling cardiomyogenesis remain poorly understood. In this report, we show that pluripotent mouse embryonal carcinoma cell...
AimsA mismatch between adequate angiogenesis and overgrowth of myocytes may be a critical mechanism controlling the transition from adaptive hypertrophy to heart failure. Canopy 2 (CNPY2) was recently identified as secreted, HIF-1α-regulated angiogenic growth factor. As factors play important roles in development myocardial hypertrophy, we investigated role CNPY2 molecular functional changes during chronic failure using cardiac-specific transgenic (TG) mice that overexpress human CNPY2.