A5101498295- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Autophagy in Disease and Therapy
- Medicinal Plants and Bioactive Compounds
- Cardiac Imaging and Diagnostics
- Amyotrophic Lateral Sclerosis Research
- Folate and B Vitamins Research
- Radiomics and Machine Learning in Medical Imaging
- Energy, Environment, Economic Growth
- Parkinson's Disease Mechanisms and Treatments
- Cardiac pacing and defibrillation studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Service-Oriented Architecture and Web Services
- Electric Vehicles and Infrastructure
- Aortic aneurysm repair treatments
- Phagocytosis and Immune Regulation
- Cloud Computing and Resource Management
- Advanced Glycation End Products research
- Firm Innovation and Growth
- Pain Management and Treatment
- Dermatological and COVID-19 studies
- MRI in cancer diagnosis
- Technology and Security Systems
- Biomarkers in Disease Mechanisms
Yunnan University of Traditional Chinese Medicine
2020-2025
Nanjing University of Chinese Medicine
2025
Central South University
2008-2024
Xijing Hospital
2006-2023
Yunnan University
2021-2023
Kunming Municipal Hospital of Traditional Chinese Medicine
2021-2023
Air Force Medical University
2006-2023
Hunan Cancer Hospital
2018-2023
Shandong University
2015-2022
Zunyi Medical University
2022
Abstract Mitochondrial dysfunction is considered as a key mediator in the pathogenesis of diabetic nephropathy (DN). Therapeutic strategies targeting mitochondrial hold considerable promise for treatment DN. In this study, we investigated role progranulin (PGRN), secreted glycoprotein, mediating homeostasis and its therapeutic potential We found that level PGRN was significantly reduced kidney from STZ-induced mice patients with biopsy-proven DN compared healthy controls. model,...
Abstract Histone deacetylase ( HDAC ) 9, a member of class II s, regulates wide variety normal and abnormal physiological functions, which is usually expressed at high levels in the brain skeletal muscle. Although studies have highlighted importance ‐mediated epigenetic processes development ischaemic stroke very recent genome‐wide association identified variant 9 associated with large‐vessel ischemic stroke, molecular events by induces cerebral injury keep unclear. In this study, we found...
Although macrophages are undoubtedly attractive therapeutic targets for acute kidney injury (AKI) because of their critical roles in renal inflammation and repair, the underlying mechanisms macrophage phenotype switching efferocytosis regulation inflammatory responses during AKI still largely unclear. The present study elucidated role junctional adhesion molecule–like protein (JAML) pathogenesis AKI. We found that JAML was significantly upregulated kidneys from 2 different murine models...
Abstract Background A number of models have been reported for predicting atrial fibrillation (AF) recurrence after catheter ablation. Although many machine learning (ML) were developed among them, black-box effect existed widely. It was always difficult to explain how variables affect model output. We sought implement an explainable ML and then reveal its decision-making process in identifying patients with paroxysmal AF at high risk Methods Between January 2018 December 2020, 471...
Objective China’s middle-aged and older population is a rich source of human capital. Therefore, considering the health this group important when creating using resources. Methods Using data from nationwide China Health Retirement Longitudinal Study (CHARLS) 2018 baseline survey 19,000 adults ages 45 years older, study was an objective investigation effects work on physical mental adults. We conducted several types analyses details participants’ lifestyles demographic characteristics (living...
Pulmonary fibrosis (PF) is a severe lung disease that manifests as tissue destruction and collagen deposition easily leads to respiratory failure. It difficult reverse these conditions using current treatment methods. This study focused on the exploration development of novel drugs for PF. simulated pathological process PF by bleomycin (BLM)-induced rat model TGF-β1-induced in vitro cell model. Dian sanguis draconis (DSD) was used intervention, effects structure, fiber deposition, autophagy...
Hyperhomocysteinemia (hHcys) is an important independent risk factor for the development of cardiovascular disease and end-stage renal disease. Although multiple approaches lowering levels homocysteine have been used in experimental studies clinical trials, there no effective therapy available to fully prevent homocysteine-induced injury. Therefore, identifying key molecules pathogenic pathways may provide clues develop new therapeutic strategies treatment hHcys-associated injury beyond...
Abstract Background Chinese Yunnan Province, located in the Yunnan–Guizhou Plateau, is a famous tourist paradise where acute high-altitude illness common occurs among lowland people visitors due to non-acclimatization hypobaric hypoxia (AHH) conditions. Traditional medicine, such as Qi-Long-Tian (QLT) formula, has shown effectiveness and safety treatment of diseases. The aim this study was clarify therapeutic mechanisms traditional formula using rat model simulated plateau environment....
The aim of the study was to investigative utility gray-level co-occurrence matrix (GLCM) texture analysis based on intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) for predicting early response chemoradiotherapy nasopharyngeal carcinoma (NPC). Baseline IVIM-DWI performed 81 patients with NPC receiving in a prospective nested case–control study. were categorized into residue (n = 11) and nonresidue 70) groups, according whether there local residual lesion or not at end...
To investigate the performance of mean parametric values and texture features based on intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) identifying pathological complete response (pCR) to neoadjuvant chemoradiotherapy (nCRT) in locally advanced rectal cancer (LARC). Pretreatment IVIM-DWI was performed 41 LARC patients receiving nCRT this prospective study. The parameters (apparent diffusion coefficient, ADC; pure D; pseudo-diffusion D* perfusion fraction, f), first-order,...
With the technological progress of photovoltaic (PV) enterprises, subsidy standard PV power generation in China is declining. However, conservative adjustment feed-in tariff (FIT) policy considered to increase financial burden government, while aggressive will have a serious impact on enterprises and may reduce research development (R&D) investment them. By constructing game model between government this article analyzes relationship R&D enterprises. The evolution path...
Background: The data on iatrogenic atrial septal defect (iASD) after left appendage closure (LAAC), especially intracardiac echocardiography (ICE)-guided LAAC, are limited. Compared with transesophageal (TEE)- or digital subtraction angiography (DSA)-guided the transseptal puncture (TP) ICE-guided LAAC is more complicated. Whether not TP increases chances of iASD controversial. We investigate incidence, size, and clinical outcomes LAAC. Methods: A total 177 patients who underwent were...
A one-stop procedure involving catheter ablation and left atrial appendage occlusion (LAAO) is an option for high-risk fibrillation patients. Few studies have reported the efficacy safety of cryoballoon (CBA) combined with LAAO, no compared combination LAAO CBA or radiofrequency (RFA).A total 112 patients were enrolled in present study; 45 received (group 1), 67 RFA 2). Patient follow-up was performed 1 year to detect peri-device leaks (PDLs) outcomes (defined as a composite peri-procedural...
With the converging of grid computing and Web service, has extended its territory from traditional to service oriented grid, aiming realize coordinated resource sharing problem solving through selection composition. Therefore, selecting credible services for applications becomes a key issue in environment. To ensure this, Bayesian network based approach is presented evaluate trustworthiness service. Two new concepts, namely QoS satisfactoriness, are introduced into proposed method, which...
With the converging of grid computing and Web service, has extended its territory from traditional to service-oriented grid, which is aiming realize coordinated resource sharing problem solving through service selection composition. Therefore, selecting credible services for applications becomes a key issue in environment. Current research on trust inherits conception P2P network coarse-grained subjective satisfy requirements In this paper, novel model considering userpsilas QoS constraints...
Background: Ethanol infusion in the vein of Marshall (EI-VOM) has advantages reducing burden atrial fibrillation (AF), decreasing AF recurrence, and facilitating left pulmonary isolation mitral isthmus bidirectional conduction block. Moreover, it can lead to prominent edema coumadin ridge infarction. Whether these lesions will affect efficacy safety appendage occlusion (LAAO) not yet been reported. Objectives: To explore clinical outcome EI-VOM on LAAO during implantation after 60 days...
Abstract Pulmonary fibrosis (PF) is a special type of pulmonary parenchymal disease, with chronic, progressive, fibrosis, and high mortality. There lack safe, effective, affordable treatment methods. Qilongtian (QLT) traditional Chinese prescription that composed Panax notoginseng, Earthworm, Rhodiola, shows the remarkable clinical curative effect PF. However, mechanism QLT remains to be clarified. Therefore, we studied effectivity in treating Bleomycin (BLM) induced PF mice. 36 C57BL/6 J...
Whether male and female patients with atrial fibrillation (AF) differ in their risk of recurrence after catheter ablation remains controversial. Large differences baseline characteristics between males females often affect study results.Patients drug-refractory paroxysmal AF who received first procedure January 2018 December 2020 were retrospectively enrolled. Propensity score matching was used to adjust for age, body mass index, duration. Our main concerns sex comorbidities, procedures,...