A5004603786- Cancer Genomics and Diagnostics
- Air Quality and Health Impacts
- HER2/EGFR in Cancer Research
- MicroRNA in disease regulation
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- Pancreatic and Hepatic Oncology Research
- Cancer Treatment and Pharmacology
- COVID-19 Clinical Research Studies
- Stroke Rehabilitation and Recovery
- Knee injuries and reconstruction techniques
- Epigenetics and DNA Methylation
- Orthopaedic implants and arthroplasty
- Long-Term Effects of COVID-19
- Acute Ischemic Stroke Management
- Gastric Cancer Management and Outcomes
- Breast Cancer Treatment Studies
- S100 Proteins and Annexins
- Hepatocellular Carcinoma Treatment and Prognosis
- Total Knee Arthroplasty Outcomes
- Genetic factors in colorectal cancer
- Air Quality Monitoring and Forecasting
- RNA modifications and cancer
- Chemotherapy-induced cardiotoxicity and mitigation
- Climate Change and Health Impacts
Georgetown University Medical Center
2018-2025
Georgetown University
2018-2025
Shanghai Zhabei District Shibei Hospital
2025
Beijing Institute of Technology
2023-2024
Shandong University of Traditional Chinese Medicine
2022-2024
Shandong Institute of Food and Drug Inspection
2022-2024
Second Military Medical University
2007-2024
MedStar Georgetown University Hospital
2024
MedStar Washington Hospital Center
2024
Beijing Sport University
2023
Pre-eclampsia is a leading cause of maternal and foetal morbidity mortality worldwide. Insufficient uteroplacental oxygenation believed to be responsible for the disease. However, what molecular events involve in hypoxic responses how they affect placental development remain unclear. Recently, miRNAs have emerged as new class molecules response hypoxia. We show here that expression microRNA-210 (mir-210) up-regulated patients with pre-eclampsia, well trophoblast cells cultured under...
HER2-targeted therapies have substantially improved the outcome of patients with breast cancer, however, they can be associated cardiac toxicity. Guidelines recommend holding until resolution dysfunction. SAFE-HEaRt is first trial that prospectively tests whether these safely administered without interruptions in dysfunction.Patients stage I-IV HER2-positive cancer candidates for trastuzumab, pertuzumab or ado-trastuzumab emtansine (TDM-1), left ventricular ejection fraction (LVEF) 40-49%...
Early‐onset hepatocellular carcinoma (HCC) accounts for 15%‐20% of total HCC cases in Asia, and the incidence is increasing. The low frequency cirrhosis poor prognosis early‐onset suggests that its mechanisms may differ from late‐onset HCC. Although hepatitis B virus (HBV) infection epidemiologically associated with HCC, role HBV remains poorly understood. Here, we report a comparative study subgenotypes integration early‐ (≤30) (≥70) HBV‐associated using novel high‐throughput viral...
Abstract Chemotherapy and immune checkpoint inhibitors have a role in the post-neoadjuvant setting patients with triple-negative breast cancer (TNBC). However, effects of nivolumab, inhibitor, capecitabine, or combination changing peripheral immunoscore (PIS) remains unclear. This open-label randomized phase II OXEL study (NCT03487666) aimed to assess immunologic terms change PIS (primary endpoint). Secondary endpoints included presence ctDNA, toxicity, clinical outcomes at 2-years...
Current literature provided information that alteration in microRNA expression impacted sensitivity or resistance of certain tumor types to anticancer treatment, including the possible intracellular pathways. The microRNA-23a (miR-23a)-regulated apoptosis response 5-fluorouracil (5-FU)-induced mitochondria-mediated apoptotic pathway was determined this study. miR-23a 5-FU-treated and untreated colon cancer cells tissues assessed using real-time PCR analysis. To determine function regulation...
Here, we report on a phase IIa study to determine the intubation rate, survival, viral clearance, and development of endogenous Abs in patients with COVID-19 pneumonia treated convalescent plasma (CCP) containing high levels neutralizing anti-SARS-CoV-2 Abs. Radiographic laboratory evaluation confirmed all 51 had pneumonia. Fresh or frozen CCP from donors titers was administered. The nonmechanically ventilated (n = 36) an rate 13.9% 30-day survival 88.9%, overall for comparative group based...
Acute kidney injury (AKI) induced by cisplatin (CP), a first-line anticancer drug for chemotherapy, is common. To date, there an urgent need to find effective treatments reduce the nephrotoxicity caused CP. Meanwhile, restoration of mitochondrial dysfunction shows potential be used as adjunct conventional therapeutic strategies. This study found that liquiritigenin can ameliorate and acute CP in mice. The intraperitoneal injection 15 mg/kg body weight 2 days markedly protected against...
The molecular mechanisms responsible for angiogenesis and abnormal expression of angiogenic factors in gastric cancer, including vascular endothelial growth factor (VEGF), remain unclear. histone demethylase retinoblastoma binding protein 2 (RBP2) is involved tumorgenesis by inhibiting the cyclin-dependent kinase inhibitors (CDKIs).The RBP2, VEGF, CD31, CD34 Ki67 was assessed 30 human cancer samples normal control samples. We used quantitative RT-PCR, western blot analysis, ELISA,...
Abstract Colorectal cancer ( CRC ) exhibiting MSI (microsatellite instability) represents a well‐defined subtype characterized by deficient mismatch repair pathway and typical clinico‐pathological features. Our objective was to identify the entire miRNome its molecular pathological roles in CRCs . We profiled miRNA expression compared it with MSS counterparts. Microarray qRT‐PCR analysis identified eight miRNAs that could distinguish status of MiR ‐484 most significantly decreased ,...
// Yangyang Wang 1, * , Jiping Zeng 2, Jianyong Pan 3 Xue Geng 1 Lupeng Li 2 Jing Wu Ping Song Ying Jilan Liu Lixiang Department of Pharmacology, Shandong University School Medicine, Jinan 250012, P.R.China Biochemistry and Molecular Biology, P.R. China Hepatobiliary Surgery, Qilu Hospital University, These authors have contributed equally to this work Correspondence to: Wang, email: wanglx@sdu.edu.cn Keywords: miR-320a, FoxM1, proliferation, gastric cancer, P27 KIP1 Received: December 06,...
Background: Recently, there has been an increase in prescription drug abuse and related fatalities. Although opioid analgesics are commonly implicated, have significant increases the prevalence of benzodiazepine exposures overdoses.Objective: To describe national trends pediatric from 2000 to 2015.Methods: A retrospective database analysis was conducted. Data regarding children ages 0 <18 years reported participating United States poison centers January through December 2015 were obtained...
To investigate the effects of dapagliflozin, in addition to standard therapy, on heart rate variability (HRV), soluble growth stimulation expressed gene 2 protein (sST2), N-terminal pro B-type natriuretic peptide (NT-proBNP), and echocardiographic parameters patients with early-onset post-myocardial infarction failure (HF). A total 98 HF were enrolled randomly divided into a control group (n = 48, receiving therapy) an observation 50, therapy plus dapagliflozin 10 mg daily). HRV, cardiac...
Objective: To assess outcomes of CI in adolescent patients with ANSD, a population which has not yet been comprehensively reviewed through scoping review. Methods: A review accordance Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. comprehensive search MEDLINE, EMBASE, Cochrane DSR, CENTRAL, CINAHL, Web Science was performed. Cohort case studies evaluating adolescents ANSD were selected. report an patient who underwent from our tertiary care academic...
696 Background: ctDNA is a powerful tool that can detect MRD with limited but emerging data in patients (pts) PDAC. We describe the clinical outcomes of pts PDAC who underwent real-world testing at our institutions. Methods: retrospectively analyzed 2 institutions ≥1 tumor-informed test (Natera, Inc) ordered for post-operation (post-op) between June 2020-August 2024. Descriptive statistics were used to characterize clinicopathologic factors, positivity (ctDNA+), and relapse rates (RR)....
623 Background: The EpiSwitch Checkpoint Inhibitor Response Test (CiRT) is a blood-based assay that analyzes DNA conformations in immune cells to predict responses checkpoint inhibitors (ICIs) targeting PD-L1/PD-1. CiRT has demonstrated superior predictive accuracy compared traditional biomarkers, such as tumor mutational burden (TMB) and PD-L1 immunohistochemistry (IHC), for predicting urothelial cancer (ESMO 2022). However, its role hepatocellular carcinoma (HCC) other gastrointestinal...
Goals To gain an insight into the putative role of annexin A5 (ANXA5) in tumor stage and its clinical outcome. Background ANXA5 is a calcium-binding protein, which has been implicated carcinogenesis several carcinomas. However, colorectal cancer (CRC) unclear. Study We investigated expression adenocarcinoma. This study included 207 consecutive patients with sporadic CRC. Paired tissue samples corresponding nonmalignant tissues were obtained by surgical resection. mRNA protein each assessed...
In China, studies on lead exposure to grownup are scarce compared children, although relevant disease burdens for adults much severe than that in developed countries. The present study evaluated blood levels (BLLs) Chinese by data mining using Monte Carlo simulation. A total of 115 scientific published between January 1980 and March 2021 reflecting 45,514 were included the study. After a continuous increase adult BLLs from 1980-1983 (GM 74.84 μg/L) 1994-1996 92.27 μg/L), began decline...
Abstract Background Pneumonia is one of the principal reasons for incidence and death in world. The former research mainly concentrated on specific sources patients. Besides, due to heterogeneity among regions, there are inconsistencies outcome these surveys. To explore relationship between atmospheric pollution hospital visits pneumonia under climate conditions Qingdao, we carried out this study. Methods medical records patients were gathered from affiliated Qingdao University during Jan...