A5048278410- Chemotherapy-induced cardiotoxicity and mitigation
- Cardiac Ischemia and Reperfusion
- Cardiovascular Function and Risk Factors
- Cardiac electrophysiology and arrhythmias
- Cardiac Imaging and Diagnostics
- Vitamin C and Antioxidants Research
- Cancer Treatment and Pharmacology
- Ion channel regulation and function
- Cardiac Fibrosis and Remodeling
- Nitric Oxide and Endothelin Effects
- Adipose Tissue and Metabolism
- Electron Spin Resonance Studies
- Mitochondrial Function and Pathology
- Antioxidant Activity and Oxidative Stress
- Cardiomyopathy and Myosin Studies
- Immune Response and Inflammation
- Coenzyme Q10 studies and effects
- Heart Failure Treatment and Management
- HER2/EGFR in Cancer Research
- Atherosclerosis and Cardiovascular Diseases
- Tissue Engineering and Regenerative Medicine
- Calcium signaling and nucleotide metabolism
- Endoplasmic Reticulum Stress and Disease
- Parkinson's Disease Mechanisms and Treatments
- Signaling Pathways in Disease
St. Boniface Hospital
2016-2025
Methodist Dallas Medical Center
2025
University of Manitoba
2016-2025
University of Central Florida
2012-2023
Research Manitoba
2011-2020
University of Minnesota Rochester
2015
University of Toronto
2013
University Health Network
2013
Shanghai Jiao Tong University
2013
Toronto Public Health
2012
Effects of an antioxidant, vitamin E, and a membrane stabilizing agent, zinc, were examined on the isoproterenol-induced changes in rat myocardium. Isoproterenol treatment (80 mg/kg given over 2 days two equal doses) caused arrhythmias 25% mortality within 24 h last injection. The ultrastructural subendocardium focal areas subepicardium included swelling mitochondria, loss myofibrils, cell necrosis, fibrosis, infiltration affected by polymorphonucleocytes. Both creatine phosphate adenosine...
Background The usefulness of adriamycin (ADR), a potent antitumor antibiotic, is limited by the development life-threatening cardiomyopathy and congestive heart failure. Subcellular changes leading to failure are suggested be mediated drug-induced increase in free radicals lipid peroxidation. In an earlier study, concurrent treatment with probucol (PROB), lipid-lowering drug strong antioxidant properties, was shown offer only partial protection against ADR cardiomyopathy. present study had...
Background Heart failure subsequent to myocardial infarction (MI) is accompanied by depressed antioxidants and increased oxidative stress in the myocardium. Antioxidant enzyme activities were examined viable left (LV) right (RV) ventricles relation their hemodynamic function. Methods Results The coronary artery rats was ligated. At 1 week after MI, LV systolic pressure (LVSP), end-diastolic (LVEDP), RV (RVEDP) remained near control values, whereas (RVSP) significantly elevated. In 4, 8, 16...
BACKGROUND The potential usefulness of adriamycin (ADR) is restricted because its cardiotoxic side effects. Since free radicals and lipid peroxidation are suggested to be involved in ADR cardiomyopathy, we examined the beneficial effects probucol, a lipid-lowering drug with strong antioxidant properties. METHODS AND RESULTS was administered rats six equal intraperitoneal injections over period 2 weeks (cumulative dose 15 mg/kg). After 3-week posttreatment period, cardiomyopathy congestive...
In patients with breast cancer, the administration of doxorubicin and trastuzumab is associated an increased risk cardiotoxicity. Although multiple-gated acquisition (MUGA) scans two-dimensional transthoracic echocardiography (TTE) are conventional methods for baseline serial assessment left ventricular ejection fraction (LVEF) in these patients, little known about use real-time three-dimensional TTE (RT3D TTE) this clinical setting. The aim study was to assess accuracy MUGA, 2D TTE, RT3D...
AimsWe have recently reported that tumour necrosis factor-α (TNF-α) increases oxidative stress and apoptosis in cardiomyocytes by upregulating p38 mitogen-activated protein (MAP) kinase (MAPK) phosphorylation. Interleukin-10 (IL-10) blocked these effects of TNF-α extracellular signal-regulated 1/2 (ERK 1/2) MAPK However, the precise site this IL-10 action is still unknown, investigated present study.
Increase in oxidative/nitrosative stress is one of the mechanisms associated with development cardiotoxicity due to doxorubicin (Dox), a potent chemotherapy drug. Previously, we reported mitigation Dox-induced and apoptosis by vitamin C (Vit C) isolated cardiomyocytes. In present vivo study rats, investigated effect prophylactic treatment Vit on apoptosis, inflammation, stress, cardiac dysfunction, transporter proteins. Dox (cumulative dose: 15 mg/kg) rats reduced systolic diastolic function...
Doxorubicin (Dox) exhibits a high efficacy in the treatment of numerous types cancer. However, beneficial cytotoxic effects Dox are often accompanied by an increase risk cardiotoxicity. Oxidative stress (OS) plays key role Dox‑induced cardiomyopathy (DIC). OS cardiomyocytes disrupts endoplasmic reticulum (ER) function, leading to accumulation misfolded/unfolded proteins known as ER stress. acts adaptive mechanism; however, prolonged together with may lead initiation cardiomyocyte apoptosis....
The clinical usefulness of adriamycin is restricted by the development congestive heart failure. It has been suggested that probucol, a strong antioxidant, completely prevents adriamycin-induced cardiomyopathy without interfering with its antitumor properties. present study investigated effects and probucol on myocardial antioxidant enzyme activities immunoreactive protein levels in rats.Activities glutathione peroxidase (GSHPx) were significantly decreased from 2 to 24 hours, those...
The purpose of the present study was to examine myocardial antioxidant and oxidative stress changes in male female rats presence physiological sex hormone concentrations after castration. Twenty-four 9-week-old Wistar were divided into four groups 6 animals each: 1) sham-operated females, 2) castrated 3) males, 4) males. When testosterone estrogen levels measured by radioimmunoassay, significant differences observed between control (both males females), demonstrating success Progesterone...