A5100424120- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Musculoskeletal pain and rehabilitation
- Cervical and Thoracic Myelopathy
- Additive Manufacturing Materials and Processes
- Scoliosis diagnosis and treatment
- Additive Manufacturing and 3D Printing Technologies
- Cancer Mechanisms and Therapy
- Spinal Cord Injury Research
- Spinal Hematomas and Complications
- Medical Imaging and Analysis
- Osteoarthritis Treatment and Mechanisms
- Peptidase Inhibition and Analysis
- Anesthesia and Neurotoxicity Research
- Pediatric Hepatobiliary Diseases and Treatments
- High Entropy Alloys Studies
- Cardiac Ischemia and Reperfusion
- Cancer-related molecular mechanisms research
- Lung Cancer Treatments and Mutations
- Tendon Structure and Treatment
- MicroRNA in disease regulation
- Congenital Anomalies and Fetal Surgery
- Pectus Deformity Diagnosis and Treatment
- Pregnancy-related medical research
- Extracellular vesicles in disease
Union Hospital
2016-2025
Huazhong University of Science and Technology
2015-2025
Beihang University
2024
Hebei University of Science and Technology
2024
Jilin University
2024
Union Hospital
2016-2023
Wuhan National Laboratory for Optoelectronics
2019-2023
First Affiliated Hospital of Jinan University
2022
Army Medical University
2021
Chongqing Medical University
2021
Abstract Objective Lactate accumulation is an important factor in the intervertebral disc degeneration (IVDD). Currently, effect and underlying mechanism of action lactate on nucleus pulposus (NP) cell inflammation during IVDD are unclear. Previous studies have found that NLRP3 inflammasome plays role regulation NP inflammation. This study focused acid‐sensitive ion channels (ASICs) relation to pyroptosis levels cells under acidic conditions. Design For vitro experiments, human were exposed...
Ferroptosis is a specialized form of regulated cell death that charactered by iron‐dependent lethal lipid peroxidation, process associated with multiple diseases. However, its role in the pathogenesis intervertebral disc degeneration (IVDD) rarely investigated. This study aimed at investigating ferroptosis oxidative stress‐ (OS‐) induced nucleus pulposus (NPC) decline and IVDD determine underlying regulatory mechanisms. We used tert‐butyl hydroperoxide (TBHP) to simulate OS conditions around...
Rationale: Remote ischemic conditioning induced by repeated episodes of transient limb ischemia is a clinically applicable method for protecting the heart against injury at time reperfusion. Objective: To assess effect chronic, repeated, remote on infarct size and long-term remodeling after myocardial infarction. Methods Results: Rats with ischemia/reperfusion received different protocols conditioning. While single early episode during coronary occlusion (perconditioning) resulted in...
Intervertebral disc (IVD) degeneration contributes largely to pathoanatomical and degenerative changes of spinal structure that increase the risk low back pain. Apoptosis in nucleus pulposus (NP) can aggravate IVD degeneration, increasing studies have shown interventions targeting NP cell apoptosis ameliorate exhibiting their potential for use as therapeutic strategies. Recent data advanced glycation end products (AGEs) accumulate tissues parallel with progression form a microenvironment...
Intervertebral disc degeneration is widely recognized as a cause of lower back pain, neurological dysfunction and other musculoskeletal disorders. The major inflammatory cytokine IL-1β associated with intervertebral degeneration; however, the molecular mechanisms that drive production in disc, especially nucleus pulposus (NP) cells, are unknown. In some tissues, advanced glycation end products (AGEs), which accumulate NP tissues promote its degeneration, increase oxidative stress secretion,...
Oxidative stress-induced mitochondrial dysfunction and nucleus pulposus (NP) cell apoptosis play crucial roles in the development of intervertebral disc degeneration (IDD). Increasing studies have shown that interventions targeting impaired autophagic flux can maintain cellular homeostasis by relieving oxidative damage. Here, we investigated effect curcumin (CUR), a known autophagy activator, on IDD vitro vivo. CUR suppressed tert-butyl hydroperoxide- (TBHP-) induced stress thereby inhibited...
Extracellular vesicles (EVs) are potential alternatives for mesenchymal stem cells (MSCs) in the treatment of musculoskeletal degenerative diseases, including intervertebral disc degeneration (IDD). Usually, EVs internalized and then deliver bioactive molecules that impart phenotypic changes recipient cells. For effective utilization IDD therapy, understanding mechanism EV uptake is vital importance. In this study, we found delivered antioxidant proteins to protect against pyroptosis nucleus...
Increased tissue stiffness is associated with various pathological processes, such as fibrosis, inflammation, and aging. The matrix of the nucleus pulposus (NP) tissues increases gradually during intervertebral disc degeneration (IDD), while mechanism through which NP cells sense react to remains unclear. In this study, results indicate that ferroptosis involved in stiff substrate-induced cell death. expression acyl-CoA synthetase long-chain family member 4 (ACSL4) group, mediates lipid...
Intervertebral disc degeneration (IDD) is the most critical pathological factor in development of low back pain. The maintenance nucleus pulposus (NP) cell and intervertebral integrity benefits largely from well-controlled mitochondrial quality, surveilled by dynamics (fission fusion) mitophagy, but outcome cellular context-dependent that remain to be clarified. Our studies revealed loss NLRX1 correlated with NP senescence IDD progression, which involve disordered quality. Further using...
Purpose Selective laser melting (SLM) is an additive manufacturing process suitable for fabricating metal porous scaffolds. The unit cell topology a significant factor that determines the mechanical property of Therefore, purpose this paper to evaluate effects on compression properties Cobalt–chromium (Co-Cr) scaffolds fabricated by SLM using finite element (FE) and experimental measurement methods. Design/methodology/approach Co-Cr alloy constructed in four different topologies, i.e. cubic...