A5100435381- Lymphoma Diagnosis and Treatment
- Spine and Intervertebral Disc Pathology
- Chronic Lymphocytic Leukemia Research
- Musculoskeletal pain and rehabilitation
- Vitamin D Research Studies
- Genetic factors in colorectal cancer
- Medical Imaging and Analysis
- Scoliosis diagnosis and treatment
- Immune Cell Function and Interaction
- Colorectal Cancer Treatments and Studies
- Spondyloarthritis Studies and Treatments
- Multiple Sclerosis Research Studies
- Magnolia and Illicium research
- Oxidative Organic Chemistry Reactions
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Cardiac Ischemia and Reperfusion
- Acute Myeloid Leukemia Research
- Viral-associated cancers and disorders
- Systemic Lupus Erythematosus Research
- Cancer Mechanisms and Therapy
- Pregnancy-related medical research
- Signaling Pathways in Disease
- Heat shock proteins research
- Protein Degradation and Inhibitors
China Pharmaceutical University
2025
Yinchuan First People's Hospital
2022-2025
Ningxia Medical University
2025
Chongqing Medical University
2025
Southeast University
2024
Icahn School of Medicine at Mount Sinai
2023-2024
Huazhong University of Science and Technology
2011-2024
Fudan University Shanghai Cancer Center
2018-2024
Sun Yat-sen University
2024
Sun Yat-sen University Cancer Center
2024
In Brief Study Design. Cross-sectional study. Objective. To evaluate the association between lumbar spine facet joint osteoarthritis (FJ OA) identified by multidetector computed tomography (CT) and low back pain (LBP) in community-based Framingham Heart Study. Summary of Background Data. The FJ OA LBP remains unclear. Methods. This study was an ancillary project to A sample 3529 participants aged 40 80 underwent CT imaging assess aortic calcification. One hundred eighty-eight individuals...
Ferroptosis is a specialized form of regulated cell death that charactered by iron‐dependent lethal lipid peroxidation, process associated with multiple diseases. However, its role in the pathogenesis intervertebral disc degeneration (IVDD) rarely investigated. This study aimed at investigating ferroptosis oxidative stress‐ (OS‐) induced nucleus pulposus (NPC) decline and IVDD determine underlying regulatory mechanisms. We used tert‐butyl hydroperoxide (TBHP) to simulate OS conditions around...
Cross-sectional study.To evaluate the association between lumbar spine facet joint orientation, tropism, and osteoarthritis (OA) degenerative spondylolisthesis (DS) identified by multidetector computed tomography in community-based Framingham Heart Study.The OA, DS, orientation tropism remains unclear. METHODS.: This study was an ancillary project to Study. A sample of 3529 participants Study aged 40 80 underwent imaging assess aortic calcification. One hundred eighty-eight individuals were...
Prior studies that have concluded disk degeneration uniformly precedes facet been based on convenience samples of individuals with low back pain. We conducted a study to examine whether the view spinal begins anterior structures is supported by epidemiologic observations in community-based population. 361 participants from Framingham Heart Study were included this study. The prevalences vertebral structure (disk height loss) and posterior (facet joint osteoarthritis) characterized CT...
Purpose Current diagnostic tests for diffuse large B-cell lymphoma use the updated WHO criteria based on biologic, morphologic, and clinical heterogeneity. We propose a refined classification system subset-specific B-cell–associated gene signatures (BAGS) in normal hierarchy, hypothesizing that it can provide new biologic insight prognostic value. Patients Methods combined fluorescence-activated cell sorting, expression profiling, statistical modeling to generate BAGS naive, centrocyte,...
Bruton's tyrosine kinase (BTK), a non-receptor kinase, is member of the Tec family kinases and essential for B cell receptor (BCR) mediated signaling. BTK also plays critical role in downstream signaling pathways Fcγ monocytes, Fcε granulocytes, RANK osteoclasts. As result, pharmacological inhibition anticipated to provide an effective strategy clinical treatment autoimmune diseases such as rheumatoid arthritis lupus. This article will outline evolution our identify covalent, irreversible...
Autogenous Iliac Crest Bone Graft (ICBG) has been the "gold standard" for spinal fusion. However, bone graft harvest may lead to complications, such as chronic pain, numbness, and poor cosmesis. The long-term impact of these complications on patient function well-being not established but is critical in determining value expensive substitutes recombinant morphogenic protein. We thus aimed investigate ICBG. Our second aim was evaluate psychometric properties a new measure ICBG morbidity that...
Objective: The aim of our study was to evaluate the association between age, sex and body mass index (BMI) lumbar spine degeneration features evaluated on computed tomography (CT) in a community-based sample. Methods: This cross-sectional w
No well-established biomarkers are available for the clinical diagnosis of major depressive disorder (MDD). Vitamin D-binding protein (VDBP) is altered in plasma and postmortem dorsolateral prefrontal cortex (DLPFC) tissues MDD patients. Thereby, role VDBP as a potential biomarker was further assessed. Total extracellular vesicles (EVs) brain cell-derived EVs (BCDEVs) were isolated from first-episode drug-naïve or drug-free patients well-matched healthy controls (HCs) discovery (20 20 HCs)...
Diffuse large B-cell lymphoma (DLBCL) is an aggressive malignancy. Neutrophil extracellular traps (NETs) are pathogen-trapping structures in the tumor microenvironment that affect DLBCL progression. However, predictive function of NET-related genes (NRGs) has received little attention. This study aimed to investigate interaction between NRGs and prognosis as well their possible association with immunological microenvironment.The gene expression clinical data patients were downloaded from...
The mechanism underlying colorectal cancer (CRC) initiation and progression remains elusive, overall survival is far from satisfactory. Previous studies have shown that PDGFA-associated protein 1 (PDAP1) upregulated in several cancers including CRC. Here, we aimed to identify the cause consequence of PDAP1 dysregulation CRC evaluate its role as a potential therapeutic target.Multi-omics data analysis was performed key players progression. Immunohistochemistry (IHC) staining applied determine...
Vitamin D (VD) levels are closely related to the occurrence of post-COVID-19 conditions (PCCs), but specific mechanism is still unclear. Here, a total 50 PCC patient serum samples were divided into VD sufficient group (VD ≥ 30 ng/mL), insufficient (20 ng/mL ≤ < and deficiency 20 ng/mL) then subjected proteomic analysis. We identified 15 differential abundance proteins (DAPs) between groups, including 5 immunoglobulin (JCHAJN, IGHV4–28, GHV4–34, IGHM, IGLV2–11), which significantly negatively...
The collagen β (1-O) glycosyltransferase 25 domain 1 (GLT25D1), a crucial collagen-modifying enzyme (CME), plays pivotal role in multiple pathophysiological processes. However, its prognostic and biological roles hepatocellular carcinoma (HCC) have not been reported. CME-related genes (CMEGs) were obtained from the Molecular Signatures Database (MSigDB), differentially expressed CMEGs (DECMEGs) ones identified. GLT25D1 expression was determined at mRNA protein levels datasets our HCC cohort....