A5100328934- Fungal Biology and Applications
- Microbial Natural Products and Biosynthesis
- Congenital Heart Disease Studies
- MicroRNA in disease regulation
- Helicobacter pylori-related gastroenterology studies
- Autoimmune Neurological Disorders and Treatments
- Cervical Cancer and HPV Research
- Coronary Artery Anomalies
- Renal Diseases and Glomerulopathies
- Mesenchymal stem cell research
- Cardiac Arrhythmias and Treatments
- Corneal Surgery and Treatments
- Wound Healing and Treatments
- Reproductive tract infections research
- Galectins and Cancer Biology
- Retinal and Optic Conditions
- Chemical synthesis and alkaloids
- Ferroptosis and cancer prognosis
- Animal Virus Infections Studies
- Pluripotent Stem Cells Research
- Lung Cancer Treatments and Mutations
- interferon and immune responses
- Tissue Engineering and Regenerative Medicine
- Peripheral Neuropathies and Disorders
- Burn Injury Management and Outcomes
Southern University of Science and Technology
2020-2025
Jinan University
2020-2025
Guangdong Provincial Health Commission
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2024
Sun Yat-sen University
2010-2024
National Institutes for Food and Drug Control
2023-2024
Guangdong Academy of Medical Sciences
2023-2024
Guangdong Provincial People's Hospital
2023-2024
Peking University
2024
Peking University Third Hospital
2024
In this review, we provide a comprehensive overview and analysis of the current advancements in nanomedicines for targeted pulmonary delivery.
This study features the isolation and identification of 12 lanostane-type triterpenoids, namely lepiotaprocerins A–L, 1–12, from fruiting bodies Poland-collected edible mushroom Macrolepiota procera. The structures absolute configurations new compounds were ambiguously established by extensive spectroscopic analyses, ECD calculation, single-crystal X-ray diffraction analyses. Structurally, A–F, 1–6, are distinguished presence a rare "1-en-1,11-epoxy" moiety which has not been previously...
SUMMARY SARS-CoV-2 has caused the global COVID-19 pandemic. Although passively delivered neutralizing antibodies against show promise in clinical trials, their mechanism of action vivo is incompletely understood. Here, we define correlates protection human monoclonal (mAbs) SARS-CoV-2-infected animals. Whereas Fc effector functions are dispensable when representative mAbs administered as prophylaxis, they required for optimal therapy. When given after infection, intact reduce burden and lung...
Sepsis-associated acute kidney injury presents as a critical condition characterized by prolonged hospital stays, elevated mortality rates, and an increased likelihood of transition to chronic disease. suppresses fatty acid oxidation oxidative phosphorylation in the mitochondria renal tubular epithelial cells, thus favoring metabolic shift towards glycolysis for energy production. This acts protective mechanism kidneys. However, extended reliance on may contribute atrophy, fibrosis,...
Abstract Immunity-and-matrix-regulatory cells (IMRCs) derived from human embryonic stem have unique abilities in modulating immunity and regulating the extracellular matrix, which could be mass-produced with stable biological properties. Despite resemblance to mesenchymal (MSCs) terms of self-renew tri-lineage differentiation, ability IMRCs repair meniscus underlying mechanism remains undetermined. Here, we showed that demonstrated stronger immunomodulatory pro-regenerative potential than...
Traumatic brain injury (TBI) and its resulting complications pose a major challenge to global public health, in increased rates of disability mortality. Cerebrovascular dysfunction is nearly universal TBI cases closely associated with secondary after TBI. Transcranial direct current stimulation (tDCS) shows great potential the treatment TBI; however, exact mechanism remains elusive. In this study, we performed vivo vitro experiments explore effects mechanisms tDCS controlled cortical impact...
Background Increasing evidence has suggested that major depression ( MD ) is associated with an increased risk of ischemic heart disease IHD ). We examined this association in Chinese adults using data from the China Kadoorie Biobank study. Methods and Results Over 0.5 million aged 30 to 79 years were followed baseline interview (2004–2008) until December 31, 2013. Past year was measured modified version Composite International Diagnostic Interview‐Short Form at baseline. Incident cases...
ABSTRACT The assessment of human papillomavirus (HPV) genotype distribution could inform targeted cervical cancer prevention strategies. epidemiology HPV genotypes in terms age and lesions Fujian Province, China has not been well described. This 9‐year retrospective study aimed to delineate the prevalence pattern trend among a large‐scale community‐based population. Deidentified data were retrieved from national screening program China. We included eligible women aged 35–65 years who...
Immune checkpoint inhibitors, such as pembrolizumab, have demonstrated substantial therapeutic efficacy in the treatment of cancer. However, immune-related adverse events, including myasthenia gravis (MG), present significant clinical challenges. This study presents case a 75-year-old male patient who developed generalized acetylcholine receptor antibody-positive MG following first infusion pembrolizumab for cholangiocarcinoma. The patient’s symptoms rapidly progressed to an impending...
Abstract Autoimmune congenital heart block (ACHB) is a passively acquired immune-mediated disease characterized by the presence of maternal antibodies against components Ro/SSA and La/SSB ribonucleoprotein complex that mainly affects cardiac conducting system. ACHB occurs in 2% women with positive anti-Ro/SSA anti-La/SSB causes high risk intrauterine fetal death, neonatal mortality, long-term sequelae. In this review, we first describe case to provide preliminary knowledge. Then, discuss...
ObjectiveThis study aimed to explore the experiences of couples with advanced lung cancer in coping changes their family functioning.MethodsThis included patients disease and spouses who were hospitalized a tertiary hospital Shanghai, China. Data collected through interviews that focused on three key areas: (1) patient coping, (2) spousal (3) dyadic coping. Semi-structured qualitative conducted Chinese analyzed using Braun-Clarke thematic analysis.ResultsA total 15 participated (12 men...
and Importance: Growing gastrointestinal cancers in the U.S. necessitate further research due to substantial healthcare economic impacts. This study aims analyze trends future projections for five major (colorectal, pancreatic, liver, stomach, esophageal).
Introduction Chikungunya virus (CHIKV) is a re-emerging pathogen responsible for causing outbreaks of febrile disease accompanied with debilitating joint pain. Symptoms typically persist two weeks, but more severe and chronic chikungunya illnesses have been reported, especially in the elderly. Currently, there are no licensed vaccines or antivirals against CHIKV available. In this study, we combined CHIK virus-like particle (VLP) vaccine different adjuvants to enhance immunogenicity...
Background The concurrence of anti-contactin 1 (CNTN1) antibody-associated chronic inflammatory demyelinating polyneuropathy (CIDP) and membranous nephropathy (MN) has previously been reported in the literature. CIDP with autoantibodies against paranodal proteins are defined as autoimmune nodopathies (AN) latest research. In view unclear relationship between MN, we performed a case study literature review to investigate clinical characteristics anti-CNTN AN MN. Methods We detected antibodies...
Cisplatin is the standard chemotherapeutic drug used for treatment of esophageal squamous cell carcinoma (ESCC). Acquired cisplatin resistance primary obstacle to prolonging patient survival time. Here, therapeutic effects mitochondrial calcium uniporter (MCU) inhibition on tumor growth and in ESCC were assessed. MCU was stably overexpressed or knocked down three lines cisplatin‑resistant lines. Then, proliferation, migration, membrane potential (MMP) measured by colony formation, wound...
To develop a multimodal deep transfer learning (DTL) fusion model using optical coherence tomography angiography (OCTA) images to predict the recurrence of retinal vein occlusion (RVO) and macular edema (ME) after three consecutive anti-VEGF therapies.