A5072232386- Inflammasome and immune disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Retinal Diseases and Treatments
- Pancreatic function and diabetes
- COVID-19 Clinical Research Studies
- Adipose Tissue and Metabolism
- Diabetic Foot Ulcer Assessment and Management
- Oral microbiology and periodontitis research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- interferon and immune responses
- Cell Adhesion Molecules Research
- Cytokine Signaling Pathways and Interactions
- Immune Response and Inflammation
- Calpain Protease Function and Regulation
- Pancreatic and Hepatic Oncology Research
- Traditional Chinese Medicine Studies
- Atmospheric chemistry and aerosols
- Acupuncture Treatment Research Studies
- Liver Disease Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Erythrocyte Function and Pathophysiology
- Cardiovascular Disease and Adiposity
- Pancreatitis Pathology and Treatment
- Epigenetics and DNA Methylation
- Gout, Hyperuricemia, Uric Acid
Capital Medical University
2015-2025
Beijing Tongren Hospital
2015-2025
Epsom and St Helier University Hospitals NHS Trust
2025
Huazhong University of Science and Technology
2024-2025
Baoji City Central Hospital
2025
Central Hospital of Wuhan
2025
First Affiliated Hospital of Wenzhou Medical University
2021-2024
Southern Medical University
2008-2024
Capital University
2019-2024
National Institutes for Food and Drug Control
2024
To discover new drugs to combat COVID-19, an understanding of the molecular basis SARS-CoV-2 infection is urgently needed. Here, for first time, we report crucial role cathepsin L (CTSL) in patients with COVID-19. The circulating level CTSL was elevated after and positively correlated disease course severity. Correspondingly, pseudovirus increased expression human cells vitro ACE2 transgenic mice vivo, while overexpression, turn, enhanced cells. functionally cleaved spike protein virus...
Objective To determine the role of gasdermin E (GSDME)–mediated pyroptosis in pathogenesis and progression rheumatoid arthritis (RA), to explore potential GSDME as a therapeutic target RA. Methods The expression activation caspase 3 synovium, macrophages, monocytes RA patients were determined by immunohistochemistry, immunofluorescence, Western blot analysis. correlation activated with disease activity was evaluated. pyroptotic ability from tested, effect tumor necrosis factor (TNF) on...
Airway epithelial injury in response to allergens such as toluene diisocyanate (TDI) leads persistent airway inflammation. Pyroptosis is recognized a strong proinflammatory cell death process. However, the role of pyroptosis bronchial and inflammation TDI-induced asthma remains unknown. In this study, cytotoxic effect TDI on 16HBE cells (a human line) was detected. Then experimental mouse model established for vivo study. Here we found that induced cells, evidenced by enhanced expressions...
Psoriasis is a common chronic inflammatory disease with an unclear aetiology. Keratinocytes in psoriasis are susceptible to exogenous triggers that induce cell death.
Abstract The classical axis of renin-angiotensin system (RAS), angiotensin (Ang)-converting enzyme (ACE)/Ang II/AT1, contributes to the development non-alcoholic fatty liver disease (NAFLD). However, role bypass RAS (Angiotensin-converting 2 (ACE2)/Ang-(1–7)/Mas) in hepatic steatosis is still unclear. Here we showed that deletion ACE2 aggravates steatosis, which correlated with increased expression lipogenic genes and decreased acid oxidation-related knockout ( −/y ) mice. Meanwhile,...
Proliferative diabetic retinopathy (PDR), a sight-threatening retinopathy, is the leading cause of irreversible blindness in adults. Despite strict control systemic risk factors, fraction patients with diabetes develop PDR, suggesting existence other potential pathogenic factors underlying PDR. This study aimed to investigate plasma metabotype PDR and identify novel metabolite markers for Biomarkers identified from this will provide scientific insight new strategies early diagnosis...
Hydroxychloroquine (HCQ) is one of the most commonly prescribed immune-suppressants in treating rheumatoid arthritis (RA). Our previous research showed that HCQ suppressed RA development by inhibiting T follicular helper (Tfh) cells directly. Dendritic (DCs) serve as link between innate and acquired immunity. Whether Tfh cell through DCs was not clear. In current study, we found efficiently inhibited CD86, chemokine (C-X-C motif) receptor 4 (CXCR4) expression interferon-α (IFN-α) secretion...
The majority of postmenopausal breast cancers are estrogen-dependent. Tumor-derived factors, such as prostaglandin E2 (PGE2), stimulate CREB1 binding to cAMP response elements (CREs) on aromatase promoter II (PII), leading the increased expression and biosynthesis estrogens within human adipose stromal cells (ASCs). Hypoxia inducible factor-1α (HIF-1α), a key mediator cellular adaptation low oxygen levels, is emerging novel prognostic marker in cancer. We have identified presence consensus...
Glucose-stimulated insulin secretion from islet β cells is mediated by KATP channels. However, the role of non-KATP K+ channels in largely unknown. Here, we show that a channel, KCNH6, plays key and glucose hemostasis humans mice. KCNH6 p.P235L heterozygous mutation co-separated with diabetes four-generation pedigree. Kcnh6 knockout (KO) or knockin (KI) mice had phenotype characterized changing hypoglycemia hyperinsulinemia to hyperglycemia deficiency. Islets young KO increased intracellular...
Identification of key regulators energy homeostasis holds important therapeutic promise for metabolic disorders, such as obesity and diabetes. ACE2 cleaves angiotensin II (Ang II) to generate Ang-(1-7) which acts mainly through the Mas1 receptor. Here, we identify pathway a critical regulator in maintenance thermogenesis expenditure. We found that is highly expressed brown adipose tissue (BAT) cold stimulation increases levels BAT serum. Ace2 knockout mice ( -/y ) -/- displayed impaired...
Activation of multiple inflammasomes in monocytes/macrophages is associated with the pathogenesis systemic lupus erythematosus (SLE). Gasdermin D (GSDMD)-mediated pyroptosis, a common consequence activated inflammasomes, programmed cell death strong inflammatory responses. This suggested that targeting monocyte/macrophage pyroptosis might provide an opportunity to cure SLE. Here, we aimed investigate effect disulfiram (DSF), small molecule inhibitor and its potential therapeutic mechanism...
The predictive value of microalbuminuria (MAU) for kidney damage is limited in type 2 diabetes (T2D). We studied whether a urine proteome specific sight-threatening proliferative diabetic retinopathy (PDR) an indicator to predict chronic renal insufficiency (CRI) patients with T2D.A shotgun proteomic analysis was performed MAU and PDR (case subjects) duration T2D >10 years but without any degree (control subjects). In the cohort study, 210 estimated glomerular filtration rate (eGFR) ≥80...
An increase in apoptosis and/or defects the clearance of apoptotic cells resulting massive secondary necrosis have been recognized as main causes systemic lupus erythematosus (SLE). Recent findings revealed that gasdermin E (GSDME)-mediated pyroptosis is a mechanism associated with necrosis. We aimed to investigate effects GSDME-mediated on disease activity mice. In vivo, high levels GSDME expression were observed renal tubules pristane-induced (PIL) mice and SLE patients. mice, knockout or...
Abstract Background The relationship between time‐averaged serum uric acid (TA‐SUA) levels and prognosis in peritoneal dialysis (PD) patients are rarely discussed. Methods This was a retrospective cohort study. PD recruited from January 1, 2011, to December 31, 2020, were included. Baseline follow‐up over 1 year collected calculate levels. Patients divided into four groups based on TA‐SUA quartiles: Q1 (<5.1 mg/dl), Q2 (5.1–5.8 Q3 (5.8–6.8 Q4 (>6.8 mg/dl). Results A total 487 with mean...
Diabetic macular edema (DME), a sight-threatening retinopathy, is leading cause of vision loss in persons with diabetes mellitus. Despite strict control systemic risk factors, fraction patients developed DME, suggesting the existence other potential pathogenic factors underlying DME. This study aimed to investigate plasma metabotype DME and identify novel metabolite markers for Biomarkers identified from this will provide scientific insight new strategies early diagnosis intervention To...