A5100603917- Epigenetics and DNA Methylation
- Mesenchymal stem cell research
- Viral Infections and Immunology Research
- Cardiovascular Disease and Adiposity
- Fermentation and Sensory Analysis
- Bladder and Urothelial Cancer Treatments
- Tissue Engineering and Regenerative Medicine
- Autophagy in Disease and Therapy
- Renal cell carcinoma treatment
- RNA modifications and cancer
- Congenital heart defects research
- Cardiac Fibrosis and Remodeling
- Endoplasmic Reticulum Stress and Disease
- Urinary and Genital Oncology Studies
- Biofuel production and bioconversion
- Cardiovascular Function and Risk Factors
- Animal Disease Management and Epidemiology
- Cardiomyopathy and Myosin Studies
- Cardiac Arrest and Resuscitation
- Fungal and yeast genetics research
- Ion channel regulation and function
- Food composition and properties
- Redox biology and oxidative stress
- Meat and Animal Product Quality
- Hydrogen's biological and therapeutic effects
Zhongda Hospital Southeast University
2024-2025
Mayo Clinic
2013-2025
Xijing Hospital
2021-2025
Air Force Medical University
2021-2025
Xi'an Institute of Optics and Precision Mechanics
2024
Guangdong Provincial Center for Disease Control and Prevention
2022-2024
Nanjing University of Chinese Medicine
2021-2024
Mayo Clinic in Florida
2012-2024
Southern Medical University
2009-2024
University of Chinese Academy of Sciences
2022-2024
Mitochondrial diseases display pathological phenotypes according to the mixture of mutant versus wild-type mitochondrial DNA (mtDNA), known as heteroplasmy. We herein examined impact nuclear reprogramming and clonal isolation induced pluripotent stem cells (iPSC) on Patient-derived dermal fibroblasts with a prototypical deficiency diagnosed encephalomyopathy lactic acidosis stroke-like episodes (MELAS) demonstrated dysfunction reduced oxidative reserve due heteroplasmy at position G13513A in...
Objective To determine the role of gasdermin E (GSDME)–mediated pyroptosis in pathogenesis and progression rheumatoid arthritis (RA), to explore potential GSDME as a therapeutic target RA. Methods The expression activation caspase 3 synovium, macrophages, monocytes RA patients were determined by immunohistochemistry, immunofluorescence, Western blot analysis. correlation activated with disease activity was evaluated. pyroptotic ability from tested, effect tumor necrosis factor (TNF) on...
Abstract Obesity exacerbates tissue degeneration and compromises the integrity reparative potential of mesenchymal stem/stromal cells (MSCs), but underlying mechanisms have not been sufficiently elucidated. Mitochondria modulate viability, plasticity, proliferative capacity, differentiation MSCs. We hypothesized that alterations in 5-hydroxymethylcytosine (5hmC) profile mitochondria-related genes may mediate obesity-driven dysfunction human adipose-derived MSCs were harvested from abdominal...
Abstract Clear cell renal carcinoma (ccRCC) is a common genitourinary malignancy with high mortality. However, the molecular pathogenesis of ccRCC remains unclear and effective biomarkers for daily practice are still limited. Thus, we aimed to identify potential crucial genes pathways associated carcinogenesis further analyze mechanisms implicated in tumorigenesis. In present study, expression profiles GSE 66270, 53757, 36895, 76351 were downloaded from GEO database, including 244 matched...
Dilated cardiomyopathy (DCM) due to mutations in RBM20, a gene encoding an RNA-binding protein, is associated with high familial penetrance, risk of progressive heart failure and sudden death. Although genetic investigations physiological models have established the linkage RBM20 early-onset DCM, underlying basis cellular molecular dysfunction undetermined. Modeling human genetics using high-throughput pluripotent stem cell platform was herein designed pinpoint initial transcriptome...
Background The non-pharmaceutical interventions (NPIs) against COVID-19 may have affected the transmission of hand, foot and mouth disease (HFMD). We aimed to assess impact NPIs on HFMD in high epidemic area HFMD, Guangdong Province. Methods data cases, etiological information, meteorological factors from January 1, 2012, December 31, 2021, were collected. Using a Bayesian structural time series (BSTS) model integrated counterfactual framework, we assessed effect by different intervention...
The purpose of this study was to investigate a therapeutic approach targeting the inflammatory response and consequent remodeling from ischemic myocardial injury.
Abstract Summary: Reduced representation bisulfite sequencing (RRBS) is a cost-effective approach for genome-wide methylation pattern profiling. Analyzing RRBS data challenging and specialized alignment/mapping programs are needed. Although such have been developed, comprehensive solution that provides researchers with good quality analyzable still lacking. To address this need, we developed Streamlined Analysis Annotation Pipeline (SAAP-RRBS) integrates read assessment/clean-up, alignment,...
Objectives: Glibenclamide confers neuroprotection in animal models as well retrospective clinical studies. This study determines whether glibenclamide improves outcome after cardiac arrest rats. Design: Prospective randomized laboratory study. Setting: University research laboratory. Subjects: Male Sprague-Dawley rats (n = 126). Interventions: Rats successfully resuscitated from 8-minute asphyxial were to or vehicle group. the group intraperitoneally administered with a loading dose of 10...
Identifying fastidious pathogens in patients with prosthetic joint infection (PJI) by culture is challenging. Metagenomic next-generation sequencing (mNGS) a novel culture-independent approach that associated higher likelihood for identifying pathogens. We present case where mNGS was implemented to identify Parvimonas micra, rarely reported and difficult-to-culture PJI pathogen.
We previously have shown that glibenclamide (GBC), a sulfonylurea receptor 1-transient potential M4 (SUR1-TRPM4) channel inhibitor, improves survival and neurological outcome after asphyxial cardiac arrest cardiopulmonary resuscitation (ACA/CPR). Here, we further compare the efficacy of GBC with target temperature management (TTM) determine whether is affected by TTM.Male Sprague-Dawley rats (n=213) subjected to 10-minute ACA/CPR were randomized 4 groups return spontaneous circulation...
Saccharomyces cerevisiae is susceptible to high-sugar stress in the production of bioethanol, wine and bread. Calcium signal widely involved various physiological metabolic activities cells. The present study aimed explore effects Ca
Abstract Background Autologous mesenchymal stem cells (MSCs) have emerged as a therapeutic option for many diseases. Hypertensive kidney disease (HKD) might impair MSCs’ reparative ability by altering the biomolecular properties, but characteristics of this impairment are unclear. In our previous pre-clinical studies, we found hypoxic preconditioning (HPC) enhanced angiogenesis and suppressed senescence gene expression. Thus, hypothesize that HPC would improve human MSCs enhancing their...
ABSTRACT The volume‐regulated anion channel (VRAC) plays a critical role in cell volume regulation and other fundamental physiological processes. However, the mechanism of how VRAC is activated modulated has not been completely clarified. Caveolin‐1 (Cav‐1), as an important ion binding protein, forms complexes with proteins exchangers to regulate activity function. purpose this study was explore importance value Cav‐1 cardiac activation regulation. In study, we proved that membrane protein...
Mesenchymal stromal cells (MSCs) possess therapeutic properties, which can be blunted by obesity. Autophagy, a cellular recycling process, is essential for MSC function. We investigated the mechanisms obesity affects properties of MSCs, with focus on autophagy. Adipose tissue was obtained from kidney donors [body mass index (BMI) <30 kg/m 2 , non-obese] or individuals undergoing weight loss surgery (BMI ≥30 obese) harvesting ( n = 11 each); samples were randomized to sequencing (seq; 5...
Background. Both CC and CXC chemokines direct monocyte T-cell migration activation at sites of vascular injury, but the relative contributions each chemokine class to transplant vasculopathy development have not been defined. The nonselective C, CC, binding protein, M-T7, inhibits after angioplasty renal transplant. We assessed effects three viral chemokine-binding proteins with differing ranges inhibition on plaque growth in rats aortic allograft Methods. One two myxomaviral proteins, (1)...
Numerous attempts for detection of circulating tumor cells (CTC) have been made to develop reliable assays early diagnosis cancers. In this study, we validated the application folate receptor α (FRα) as marker detect CTC through tumor-specific ligand PCR (LT-PCR) and assessed its utility bladder transitional cell carcinoma (TCC). Immunohistochemistry FRα was performed on ten TCC tissues. Enzyme-linked immunosorbent assay (ELISA) both urine serum specimens from patients (n = 64 n 20,...
Summary The effect of sucrose levels on the rheo‐fermentation properties dough were studied. Compared with control group, forming time and strength enhanced in dough, water absorption development significantly reduced. Dough 10% had highest resistance, 4% increased toughness dough. 2% better leavening ability. There was lower strong bound higher weakly compared other With increasing levels, content free significantly. no growth yeast sugar‐free medium (0%), much more suitable for growth,...