A5068338523- Advancements in Transdermal Drug Delivery
- Lymphoma Diagnosis and Treatment
- Immune Cell Function and Interaction
- Advanced Drug Delivery Systems
- CAR-T cell therapy research
- Pharmaceutical and Antibiotic Environmental Impacts
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Surfactants and Colloidal Systems
- Effects and risks of endocrine disrupting chemicals
- Synthesis and Biological Evaluation
- Virus-based gene therapy research
- Estrogen and related hormone effects
- T-cell and Retrovirus Studies
- Cancer therapeutics and mechanisms
- Histone Deacetylase Inhibitors Research
- Viral-associated cancers and disorders
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Dermatology and Skin Diseases
- Cancer Immunotherapy and Biomarkers
- Gut microbiota and health
- Drug Solubulity and Delivery Systems
- Protein Degradation and Inhibitors
- Chronic Lymphocytic Leukemia Research
First Affiliated Hospital of Zhengzhou University
2019-2025
Tobacco Research Institute
2025
Chinese Academy of Agricultural Sciences
2025
China Tobacco
2025
Xiyuan Hospital
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Shandong Provincial Hospital
2025
Shandong University
2025
Shandong Academy of Chinese Medicine
2025
Shandong Center for Disease Control and Prevention
2025
Synthetic phenolic antioxidants (SPAs) are closely correlated with human life due to their extensive usages, and increasing concerns have been raised on biosafety. The previous controversial findings caused continuous debates potential endocrine disrupting effects. In the present study, four commonly used SPAs, including butylated hydroxyanisole (BHA), hydroxytoluene (BHT), tert-butyl hydroquinone (TBHQ) 2,2′-methylenebis(6-tert-butyl-4-methylphenol) (AO2246), were investigated for...
SWEET (Sugar Will Eventually be Exported Transporter) proteins play vital roles in the transport of sugars, contributing to regulation plant development, hormone signaling, and responses abiotic stress. In this study, we identified 57 NtSWEETs tobacco (Nicotiana tabacum L.), then their physicochemical properties, chromosomal localization, synteny, phylogenetic relationships, genomic structure, promoter cis-elements, protein interaction network, tissue specificity, expression pattern were...
Abstract Clear cell renal carcinoma (ccRCC) is a common genitourinary malignancy with high mortality. However, the molecular pathogenesis of ccRCC remains unclear and effective biomarkers for daily practice are still limited. Thus, we aimed to identify potential crucial genes pathways associated carcinogenesis further analyze mechanisms implicated in tumorigenesis. In present study, expression profiles GSE 66270, 53757, 36895, 76351 were downloaded from GEO database, including 244 matched...
Accumulating evidence reveals the principal role of long noncoding RNAs in progression clear cell renal carcinoma (ccRCC).However, little is known about underlying mechanism ADAM metallopeptidase with thrombospondin type 1 motif, 9 antisense RNA 2 (ADAMTS9-AS2) ccRCC.Here, bioinformatics analyses verified ADAMTS9-AS2 a and its high expression was associated better prognosis ccRCC.ADAMTS9-AS2 clearly downregulated ccRCC clinical samples lines.Clinical data showed lowexpressed correlated worse...
Natural killer/T cell lymphoma (NKTCL) is an aggressive with a poor prognosis. Chimeric antigen receptor-transduced T (CAR-T) therapy has become promising immunotherapeutic strategy against haematologic malignancies.In this study, four CAR-T lines (CD38-CAR, LMP1-CAR, CD38-LMP1 tandem CAR 1 and 2) were generated. The effect of cells NKTCL was evaluated both in vitro vivo. Expression activation markers cytokines produced by detected flow cytometry.The could effectively eliminate malignant...
Abstract Circular RNAs (circRNAs) can regulate autophagy and ovarian cancer (OC) progression. However, autophagy-associated circRNAs involved in OC progression are largely unknown. Bioinformatics, RNA sequencing, qRT-PCR were conducted to detect circRNF144B expression as well its relationship with patient prognosis. Functional experiments used determine the effects of on proliferation, mobility OC. Double luciferase reporter assays, immunoprecipitation, ubiquitination detection performed...
Nuclear Factor Y (NF-Y) represents a group of transcription factors commonly present in higher eukaryotes, typically consisting three subunits: NF-YA, NF-YB, and NF-YC. They play crucial roles the embryonic development, photosynthesis, flowering, abiotic stress responses, other essential processes plants. To better understand genome-wide NF-Y domain-containing proteins, protein physicochemical properties, chromosomal localization, synteny, phylogenetic relationships, genomic structure,...
Abstract Background The mammalian liver executes its vital functions through intricate hepatic biochemistry. However, the complexity of metabolome and dynamic alterations during metabolic dysfunction-associated steatotic disease (MASLD) remain poorly understood. Methods We established progressive MASLD mouse models high-fat diet (HFD) high-fat/high-cholesterol (HFHC) dietary-feeding across multiple time points. Utilizing liquid chromatography-mass spectrometry (LC-MS)-based metabolomics...
Abstract Background: JS107 is a monomethyl auristatin E conjugated, CLDN18.2 specific ADC. exhibited potent anti-tumor activities in preclinical studies with tolerable safety profile. Here we report the and efficacy results of monotherapy or combination for pts advanced solid tumors from first-in-human phase 1 trial (NCT05502393). Methods: In Part A study, refractory to standard therapies were treated at 0.15-3.5 mg/kg Q3W during dose escalation CLDN18.2+ 2.0 3.0 expansion. B CLDN18.2+,...
Paraffin section is an important technique in histology research, and transparency the key step connecting procedures of dehydration wax immersion paraffin sectioning technology. However, commonly used transparent reagent xylene toxic to human body environment included list carcinogens. Few biosafe environmentally friendly reagents have been widely replace xylene. In this study, we found a green reagent, dimethyl carbonate (DMC). Physical chemical analysis showed that DMC was nontoxic...
ABSTRACT Relapsed/refractory diffuse large B‐cell lymphoma (DLBCL) patients do not receive standard rescue treatment; therefore, the exploration of new therapeutic targets for treatment DLBCL is urgently needed. Immunohistochemistry and western blotting were performed to determine expression MerTK in DLBCL. Targeted knockdown by shRNA was conducted cell lines. cell‐derived xenograft models established evaluate effects vivo. We found first time that MerTK, a proto‐oncogene, aberrantly highly...
Mantle cell lymphoma (MCL) is a rare subtype of B-cell lymphoma. Circular (circ) RNA member the non-coding family. However, clinical references to circRNAs in MCL are not clear.In this study, we detected expression level circCDYL plasma patients compared healthy donors by quantitative reverse transcription polymerase chain reaction. The diagnostic value was determined using receiver operating characteristic (ROC) curve. We constructed short hairpin plasmid and infected line, Z138, detect its...
Emerging evidence highlights the regulatory role of paired-like (PRD-like) homeobox transcription factors (TFs) in embryonic genome activation (EGA). However, majority PRD-like genes are lost rodents, thus prompting an investigation into TFs other mammals. Here, we showed that were transiently expressed during EGA human, monkey, and porcine fertilized embryos, yet they exhibited inadequate expression their cloned embryos. This study, using pig as research model, identified LEUTX a key...